A Study of Oral Ixazomib Citrate (MLN9708) Maintenance Therapy in Participants With Multiple Myeloma Following Autologous Stem Cell Transplant

Inclusion Criteria:

1. Adult male or female participants 18 years or older with a confirmed diagnosis of
symptomatic multiple myeloma according to standard criteria.

2. Documented results of cytogenetics/ fluorescence in situ hybridization (FISH)
obtained at any time before transplant, and International Staging System (ISS)
staging at the time of diagnosis available.

3. Underwent standard of care (SOC) induction therapy (induction therapy must include
proteasome inhibitor (PI) and/or immunomodulating drugs (IMiD)-based regimens as
primary therapy for multiple myeloma), followed by a single autologous stem cell
transplant (ASCT) with a high-dose melphalan (200 mg/m^2) conditioning regimen,
within 12 months of diagnosis. Vincristine, Adriamycin [doxorubicin], and
dexamethasone (VAD) is not an acceptable induction therapy for this trial.

4. Started screening no earlier than 75 days after transplant, completed screening
within 15 days, and randomized no later than 115 days after transplant.

5. Must have not received post-ASCT consolidation therapy.

6. Documented response to ASCT (PR, VGPR, CR/stringent complete response [sCR])
according to IMWG criteria.

7. ECOG performance status of 0 to 2.

8. Female participants who:

- If they are of childbearing potential, agree to practice 2 effective methods of
contraception, at the same time, from the time of signing the informed consent
through 90 days after the last dose of study drug, AND

- Must also adhere to the guidelines of any treatment-specific pregnancy
prevention program, if applicable, OR

- Agree to practice true abstinence, when this is in line with the preferred and
usual lifestyle of the participant. (Periodic abstinence [eg, calendar,
ovulation, symptothermal, postovulation methods for the female partner] and
withdrawal are not acceptable methods of contraception.) Male participants,
even if surgically sterilized (ie, status postvasectomy), who:

- Agree to practice effective barrier contraception during the entire study
treatment period and through 90 days after the last dose of study drug, AND

- Must also adhere to the guidelines of any treatment-specific pregnancy
prevention program, if applicable, OR

- Agree to practice true abstinence, when this is in line with the preferred and
usual lifestyle of the participant. (Periodic abstinence [eg, calendar,
ovulation, symptothermal, postovulation methods for the female partner] and
withdrawal are not acceptable methods of contraception.)

9. Voluntary written consent must be given before performance of any study-related
procedure not part of standard medical care, with the understanding that consent may
be withdrawn by the participant at any time without prejudice to future medical
care.

10. Suitable venous access for the study-required blood sampling.

11. Is willing and able to adhere to the study visit schedule and other protocol
requirements.

12. Must meet the following clinical laboratory criteria at study entry:

- Absolute neutrophil count (ANC) ≥ 1,000 per cubic milliliter (/mm^3) and
platelet count ≥ 75,000/mm^3. Platelet transfusions to help participants meet
eligibility criteria are not allowed within 3 days before randomization.

- Total bilirubin ≤ 1.5 * the upper limit of the normal range (ULN).

- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 * ULN.

- Calculated creatinine clearance ≥ 30 milliliter per minute (mL/min).

Exclusion Criteria:

1. Multiple myeloma that has relapsed following primary therapy or is not responsive to
primary therapy. For this study, stable disease following ASCT will be considered
nonresponsive to primary therapy.

2. Double (tandem) ASCT.

3. Radiotherapy within 14 days before the first dose of study drug.

4. Diagnosed or treated for another malignancy within 5 years before randomization or
previously diagnosed with another malignancy with evidence of residual disease.
Participants with nonmelanoma skin cancer or carcinoma in situ of any type are not
excluded if they have undergone complete resection.

5. Female participants who are lactating and breastfeeding or have a positive serum
pregnancy test during the Screening period.

6. Major surgery within 14 days before randomization.

7. Central nervous system involvement.

8. Infection requiring intravenous (IV) antibiotic therapy or other serious infection
within 14 days before randomization.

9. Diagnosis of Waldenstrom's macroglobulinemia, POEMS (polyneuropathy, organomegaly,
endocrinopathy, monoclonal gammopathy, and skin changes) syndrome, plasma cell
leukemia, primary amyloidosis, myelodysplastic syndrome, or myeloproliferative
syndrome.

10. Evidence of current uncontrolled cardiovascular conditions, including uncontrolled
hypertension, uncontrolled cardiac arrhythmias, symptomatic congestive heart
failure, unstable angina, or myocardial infarction within the past 6 months.

11. Systemic treatment with strong cytochrome P450 3A (CYP3A) inducers (rifampin,
rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital), or use of Ginkgo
biloba or St. John's wort within 14 days before randomization in the study.

12. Active hepatitis B or C virus infection, or known human immunodeficiency virus (HIV)
positive.

13. Comorbid systemic illnesses or other severe concurrent disease which, in the
judgment of the investigator, would make the participant inappropriate for entry
into this study or interfere significantly with the proper assessment of safety and
toxicity of the prescribed regimens (eg, peripheral neuropathy that is Grade 1 with
pain or Grade 2 or higher of any cause).

14. Psychiatric illness/social situation that would limit compliance with study
requirements.

15. Known allergy to any of the study medications, their analogues, or excipients in the
various formulations of any agent.

16. Inability to swallow oral medication, inability or unwillingness to comply with the
drug administration requirements, or gastrointestinal (GI) procedure that could
interfere with the oral absorption or tolerance of treatment.

17. Treatment with any investigational products within 60 days before the first dose of
the study drug regimen.