Trial at a glance
What medical condition is being studied? Chronic inflammatory demyelinating polyradiculoneuropathy
What is the trial testing? HYQVIA; 0.25% albumin placebo solution with rHuPH20; IGIV
Are placebos part of the trial? Yes
How many participants are being enrolled? 232
When is the trial being conducted? -
Key requirements
Sex
All
Age
From 18 Years
Accepts Healthy Volunteers?
No
Trial Details / Participation Requirements
CLICK TO EXPANDCLICK TO COLLAPSE
Trial Phase: Phase 3
Trial Type: Interventional
Trial Arms/Groups or Cohorts:
Epoch 1: HYQVIA/HyQvia: Participants will receive SC HYQVIA/HyQvia at a dose of 80 Unit per gram (U/g) immunoglobulin (IgG) which will be same as the participants pre-randomization monthly equivalent IgG dose (or at matching infusion volume for participants in the placebo group) when administered at a dosing frequency of every 2, 3, or 4 weeks for 6 months or until relapse.
Epoch 1: Placebo with rHuPH20: Participants will receive sequential 0.25% albumin placebo with rHuPH20 at a dose of 80U/g IgG subcutaneously for 6 months or until relapse. Dosing regimen for placebo treatment will be the same as the participant's pre-randomization monthly equivalent IgG infusion volume when administered every 2, 3, or 4 weeks.
Epoch 2: IGIV: Participants will recieve an induction dose of 2 Gram per kilogram (g/kg) Intravenous immunoglobulin G (IGIV), followed by maintenance infusions at the same monthly dose as the participant's pre-randomization IgG dose, every 3 weeks for 6 months or until relapse.
Intervention: HYQVIA; 0.25% albumin placebo solution with rHuPH20; IGIV
Primary Outcome Measure(s):
Epoch 1: Relapse Rate on Every 2 Weeks Dosing Regimen (Q2W) at Pre-SC Baseline Week 1 [Time Frame: Pre-SC Baseline (Week 1)]
Epoch 1: Relapse Rate on Every 2 Weeks Dosing Regimen (Q2W) at Week 5 [Time Frame: Week 5]
Epoch 1: Relapse Rate on Every 2 Weeks Dosing Regimen (Q2W) at Week 9 [Time Frame: Week 9]
Epoch 1: Relapse Rate on Every 2 Weeks Dosing Regimen (Q2W) at Week 13 [Time Frame: Week 13]
Epoch 1: Relapse Rate on Every 2 Weeks Dosing Regimen (Q2W) at Week 15 [Time Frame: Week 15]
Epoch 1: Relapse Rate on Every 2 Weeks Dosing Regimen (Q2W) at Week 19 [Time Frame: Week 19]
Epoch 1: Relapse Rate on Every 2 Weeks Dosing Regimen (Q2W) at Week 23 [Time Frame: Week 23]
Epoch 1: Relapse Rate on Every 2 Weeks Dosing Regimen (Q2W) at Week 27 (End of Epoch 1 Treatment [EOE1T])/Unscheduled relapse visit assessment (UV)/Early Termination (ET) [Time Frame: Week 27 (EOET1)/UV/ET]
Epoch 1: Relapse Rate on Every 3 Weeks Dosing Regimen (Q3W) at Pre-SC Baseline [Time Frame: Pre-SC Baseline]
Epoch 1: Relapse Rate on Every 3 Weeks Dosing Regimen (Q3W) at Week 5 [Time Frame: Week 5]
Epoch 1: Relapse Rate on Every 3 Weeks Dosing Regimen (Q3W) at Week 8 [Time Frame: Week 8]
Epoch 1: Relapse Rate on Every 3 Weeks Dosing Regimen (Q3W) at Week 11 [Time Frame: Week 11]
Epoch 1: Relapse Rate on Every 3 Weeks Dosing Regimen (Q3W) at Week 14 [Time Frame: Week 14]
Epoch 1: Relapse Rate on Every 3 Weeks Dosing Regimen (Q3W) at Week 17 [Time Frame: Week 17]
Epoch 1: Relapse Rate on Every 3 Weeks Dosing Regimen (Q3W) at Week 20 [Time Frame: Week 20]
Epoch 1: Relapse Rate on Every 3 Weeks Dosing Regimen (Q3W) at Week 23 [Time Frame: Week 23]
Epoch 1: Relapse Rate on Every 3 Weeks Dosing Regimen (Q3W) at Week 26 (EOE1T)/Unscheduled relapse visit assessment (UV)/Early Termination (ET) [Time Frame: Week 26 (EOE1T)/UV/ET]
Epoch 1: Relapse Rate on Every 4 Weeks Dosing Regimen (Q4W) at Pre-SC Baseline [Time Frame: Pre-SC Baseline]
Epoch 1: Relapse Rate on Every 4 Weeks Dosing Regimen (Q4W) at Week 5 [Time Frame: Week 5]
Epoch 1: Relapse Rate on Every 4 Weeks Dosing Regimen (Q4W) at Week 8 [Time Frame: Week 8]
Epoch 1: Relapse Rate on Every 4 Weeks Dosing Regimen (Q4W) at Week 12 [Time Frame: Week 12]
Epoch 1: Relapse Rate on Every 4 Weeks Dosing Regimen (Q4W) at Week 16 [Time Frame: Week 16]
Epoch 1: Relapse Rate on Every 4 Weeks Dosing Regimen (Q4W) at Week 20 [Time Frame: Week 20]
Epoch 1: Relapse Rate on Every 4 Weeks Dosing Regimen (Q4W) at Week 24 [Time Frame: Week 24]
Epoch 1: Relapse Rate on Every 4 Weeks Dosing Regimen (Q4W) at Week 28 (EOET1)/Unscheduled relapse visit assessment (UV)/Early Termination (ET) [Time Frame: Week 28 (EOET1)/UV/ET]
Epoch 2: Responder Rate on Every 3 Weeks Dosing Regimen at Pre-Baseline (Week 1) [Time Frame: Pre-IV Baseline (Week 1)]
Epoch 2: Responder Rate on Every 3 Weeks Dosing Regimen up to 6 Months (End of Epoch 2 Treatment [EOE2T])/Unscheduled visit assessment (UV)/Early Termination [Time Frame: Up to 6 Months/UV/ET]
Secondary Outcome Measure(s):
Epoch 1: Time to Relapse [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Change From Pre-Subcutaneous (SC) Treatment Baseline in Rasch-built Overall Disability Scale (R-ODS) Score [Time Frame: Pre-subcutaneous (SC) treatment baseline, then weekly through Epoch 1 (up to 6 months); Unscheduled relapse visit assessment; & if early termination occurs.]
Epoch 1: Number of Participants Experiencing Any Treatment-Emergent Serious and/or Non-serious Adverse Events (SAEs and/or AEs), Regardless of Causality [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Number of Participants Experiencing Causally Related Serious And/or Non-Serious Adverse Events (SAEs And/or AEs) [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Number of Participants With Serious And/Or Non-serious Adverse Reactions (ARs) Plus Suspected ARs [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Number of Infusions Associated with Treatment-emergent Serious And/Or Non-serious Adverse Events (SAEs And/Or AEs), Regardless of Causality [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Number of Infusions Associated with Causally Related Serious And/Or Non-serious Adverse Events (SAEs And/Or AEs) [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Number of Infusions Temporally Associated with Adverse Events (AEs) [Time Frame: During an infusion or within 72 hours after completion of an infusion]
Epoch 1: Number of Infusions Associated with Serious And/Or Non-serious Adverse Reactions (ARs) plus Suspected ARs [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Number of Infusions Associated with Treatment-emergent Systemic Adverse Events (AEs) [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Number of Infusions Associated with Treatment-emergent Local Infusion Site Reactions [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Number of Infusions for Which the Infusion Rate Was Reduced And/Or the Infusion Was Interrupted or Stopped Due to Intolerability And/Or Adverse Events (AEs) [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Rates of Systemic and Local Adverse Events (AEs), Regardless of Causality, Expressed as Number of Events Per Infusion [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Rates of Systemic and Local Adverse Events (AEs), Regardless of Causality, Expressed as Number of Events per Participant [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Rates of Systemic and Local Adverse Events (AEs), Regardless of Causality, Expressed as Number of Events per Participant-year [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Rates of Causally Related Systemic and Local Adverse Events (AEs), Expressed As Number of Events Per Infusion [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Rates of Causally Related Systemic and Local Adverse Events (AEs), Expressed As Number of Events Per Participant [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Rates of Causally Related Systemic and Local Adverse Events (AEs), Expressed as Number of Events per Participant-year [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Rates of Systemic and Local Adverse Reactions (ARs) plus Suspected Ars, Expressed as Number of Events per Infusion [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Rates of Systemic and Local Adverse Reactions (ARs) plus Suspected ARs, Expressed as Number of Events per Participant [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Rates of Systemic and Local Adverse Reactions (ARs) plus Suspected ARs, Expressed as Number of Events per Participant-Year [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 1: Number of Participants Who Develop Binding And/Or Neutralizing Antibodies to Recombinant Human Hyaluronidase (rHuPH20) [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 2: Number of Participants Experiencing Any Treatment-emergent Serious And/Or Non-serious Adverse Events (SAEs And/Or AEs), Regardless of Causality [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Number of Participants Experiencing Causally Related Serious And/Or Non-serious Adverse Events (SAEs And/Or AEs) [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Number of Participants with Serious And/Or Non-serious Adverse Reactions (ARs) plus Suspected ARs [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Number of Infusions Associated with Treatment-emergent Serious And/Or Non-serious Adverse Events (SAEs And/Or AEs), Regardless of Causality [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Number of Infusions Associated With Causally Related Serious And/Or Non-serious Adverse Events (SAEs And/Or AEs) [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Number of Infusions Temporally Associated with Adverse Events (AEs) [Time Frame: During an infusion or within 72 hours after completion of an infusion]
Epoch 2: Number of Infusions Associated with Serious And/Or Non-serious Adverse Reactions (ARs) plus Suspected ARs [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Number of Infusions Associated with Treatment-emergent Systemic Adverse Events (AEs) [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Number of Infusions Associated with Treatment-emergent Local Infusion Site Reactions [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Number of Infusions for Which the Infusion Rate Was Reduced And/Or the Infusion Was Interrupted or Stopped Due to Intolerability And/Or Adverse Events (AEs) [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Rates of Systemic and Local Adverse Events (AEs), Regardless of Causality, Expressed as Number of Events Per Infusion [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Rates of Systemic and Local Adverse Events (AEs), Regardless of Causality, Expressed as Number of Events Per Participant [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Rates of Systemic and Local Adverse Events (AEs), Regardless of Causality, Expressed as Number of Events Per Participant-year [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Rates of Causally Related Systemic and Local Adverse Events (AEs), Expressed As Number of Events Per Infusion [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Rates of Causally Related Systemic and Local Adverse Events (AEs), Expressed as Number of Events Per Participant [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Rates of Causally Related Systemic and Local Adverse Events (AEs), Expressed as Number of Events Per Participant-Year [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Rates of Systemic and Local Adverse Reactions (ARs) plus Suspected Ars, Expressed as Number of Events Per Infusion [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Rates of Systemic and Local Adverse Reactions (ARs) plus Suspected ARs, Expressed as Number of Events Per Participant [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 2: Rates of Systemic and Local Adverse Reactions (ARs) plus Suspected ARs, Expressed as Number of Events Per Participant-Year [Time Frame: Throughout Epoch 2, up to 6 months]
Epoch 1: Proportion of Participants Who Experience a Worsening of Functional Disability [Time Frame: Throughout Epoch 1, up to 6 months]
Epoch 2: Proportion of Participants With Clinically Meaningful Improvement in Functional Ability [Time Frame: Throughout Epoch 2, up to 6 months]
Entry Criteria:
Inclusion Criteria:
1. Documented diagnosis of definite or probable Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) (focal atypical CIDP and pure sensory atypical CIDP will be excluded) consistent with European Federation of Neurological Societies/Peripheral
Nerve Society (EFNS/PNS) 2010 criteria.
2. Participant has responded to IgG treatment in the past (partial or complete resolution of neurological symptoms and deficits), and must currently be on stable doses of intravenous immunoglobulin G (IGIV) treatment within the dose range equivalent to a cumulative monthly dose of 0.4 to 2.4 g/kg BW (inclusive) administered intravenously for at least 12 weeks prior to screening. The dosing interval of IGIV treatment must be between 2 and 6 weeks (inclusive). Variations in the dosing interval of up to ± 7 days or monthly dose amount of up to ± 20% between participant’s pre-study IgG infusions are within acceptable limits
3. Inflammatory Neuropathy Cause and Treatment disability scale (INCAT) disability score between 0 and 7 (inclusive). Participants with INCAT scores of 0, 1, or 2 (if at least 1 point is from an upper extremity) must have a history of significant disability - ie, INCAT disability score of 2 (must be exclusively from the lower extremities) or greater documented in the medical record.
4. If female of childbearing potential, the participant must have a negative pregnancy test at screening and agree to employ a highly effective contraceptive measure throughout the course of the study and for at least 30 days after the last administration of investigational product.
5. Participant is willing and able to sign an Informed Consent Form (ICF).
6. Participant is willing and able to comply with the requirements of the protocol.
Exclusion Criteria:
1. Focal atypical CIDP or pure sensory atypical CIDP.
2. Any neuropathy of other causes, including:
a. Hereditary demyelinating neuropathies, such as hereditary sensory and motor neuropathy (HSMN) (Charcot-Marie-Tooth [CMT] disease), multifocal acquired demyelinating sensory and motor neuropathy (MADSAM), and hereditary sensory and autonomic neuropathies (HSANs)
b. Neuropathies secondary to infections, disorders, or systemic diseases such as Borrelia burgdorferi infection (Lyme disease), diphtheria; systemic lupus erythematosus; polyneuropathy, organomegaly, endocrinopathy or edema, M-protein, skin changes (POEMS) syndrome; osteosclerotic myeloma; diabetic and non-diabetic lumbosacral radiculoplexus neuropathy; lymphoma, and amyloidosis
c. Multifocal motor neuropathy (MMN)
d. Drug-, biologic-, chemotherapy-, or toxin-induced peripheral neuropathy
3. Immunoglobulin M (IgM) paraproteinemia, including IgM monoclonal gammopathy with high titer antibodies to myelin-associated glycoprotein
4. Prominent sphincter disturbance.
5. Central demyelinating disorders (eg, multiple sclerosis).
6. Any chronic or debilitating disease, or central nervous disorder that causes neurological symptoms or may interfere with assessment of CIDP or outcome measures (eg, arthritis, stroke, Parkinson’s disease, and diabetic peripheral neuropathy)
(Participants with clinically diagnosed diabetes mellitus who do not have diabetic peripheral neuropathy, who have adequate glycemic control with Hemoglobin A1C; also known as glycosylated or glycated hemoglobin (HbA1C) of <7.5% at screening, and who agree to maintain adequate glycemic control during the study are allowed.)
7. Congestive heart failure (New York Heart Association (NYHA) Class III/IV), unstable angina, unstable cardiac arrhythmias, or uncontrolled hypertension (ie, diastolic blood pressure >100 mmHg and/or systolic blood pressure >160 mmHg).
8. History of deep vein thrombosis or thromboembolic events (eg, cerebrovascular accident, pulmonary embolism) in the past 12 months.
9. Condition(s) which could alter protein catabolism and/or IgG utilization (eg, protein-losing enteropathies, nephrotic syndrome).
10. Known history of chronic kidney disease, or glomerular filtration rate (GFR) of <60 mL/min/1.73m^2 estimated based on CKD-EPI equation (2009).
11. Participant with active malignancy requiring chemotherapy and/or radiotherapy, or history of malignancy with less than 2 years of complete remission prior to screening. Exceptions are: adequately treated basal cell or squamous cell carcinoma of the skin, carcinoma in situ of the cervix, and stable prostate cancer not requiring treatment.
12. Clinically significant anemia or hemoglobin (Hgb) level of <10.0 g/dL at screening.
13. Hypersensitivity or adverse reactions (eg, urticaria, breathing difficulty, severe hypotension, or anaphylaxis) to human blood products such as human IgG, albumin, or other blood components.
14. Known allergy to hyaluronidase of human (including recombinant human hyaluronidase) or animal origin (such as bee or wasp venom).
15. Known history of or immunoglobulin A (IgA) deficiency (<8 mg/dL) at screening.
16. Abnormal laboratory values at screening:
a. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) >2.5x upper limit of normal (ULN)
b. Platelet count <100,000 cells/µL
c. Absolute neutrophil count (ANC) <1000 cells/µL
17. Ongoing/active infection with hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV) Type 1/2 infection.
18. The participant has received or is currently receiving treatment with immunomodulatory/ immunosuppressive agents within 6 months prior to screening.
19. Participant has received or is currently receiving treatment with corticosteroids within 3 months prior to screening. The following exceptions for prednisolone or its equivalent are allowed: stable dosages of low-dose systemic corticosteroids (≤10 mg prednisolone/day or its equivalent) and non-systemic corticosteroids (eg, topical, ophthalmic, or inhaled glucocorticoids). In addition and for the purpose of treating AE or non-CIDP intercurrent disease, a single corticosteroid dose >10 mg prednisolone or a single short term course of ≤ to 7 days (such as Methylprednisolone Dose Pack) within 3 months prior to screening is allowed.
20. Participant has undergone plasma exchange within 3 months prior to screening.
21. The participant has any disorder or condition that in the investigator’s judgment may impede the participant’s participation in the study, pose increased risk to the participant, or confound the results of the study.
22. The participant is nursing or intends to begin nursing during the course of the study.
23. Participation in another clinical study involving an investigational product and/or device within 30 days prior to enrollment, or planned participation in another clinical study during the course of this study.
24. The participant is a family member or employee of the investigator.
Trial Locations
RESULTS
Barrow Neurological Institute
350 W Thomas Rd, Phoenix, AZ 85013, USA
Site Contact
Recruiting
2,140 miles (3,445 km) awayfrom
New York City, New York
New York City, New York
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Regents of the University of colorado
13001 E 17th Pl ste f-428, Aurora, CO 80045, USA
Site Contact
Recruiting
1,620 miles (2,607 km) awayfrom
New York City, New York
New York City, New York
View on Map
Immunoe Research Centers
6801 S Yosemite St, Centennial, CO 80112, USA
Site Contact
Recruiting
1,625 miles (2,615 km) awayfrom
New York City, New York
New York City, New York
View on Map
University of Kansas Medical Center Research Institute, Inc.
3901 Rainbow Blvd, Kansas City, KS 66160, USA
Site Contact
Recruiting
1,097 miles (1,766 km) awayfrom
New York City, New York
New York City, New York
View on Map
Rutgers New Jersey Medical School
185 S Orange Ave, Newark, NJ 07103, USA
Site Contact
Recruiting
11 miles (18 km) awayfrom
New York City, New York
New York City, New York
View on Map
Recruiting
401 miles (645 km) awayfrom
New York City, New York
New York City, New York
View on Map
Austin Neuromuscular Center
3901 Medical Pkwy #300, Austin, TX 78756, USA
Site Contact
Recruiting
1,512 miles (2,433 km) awayfrom
New York City, New York
New York City, New York
View on Map
University Texas Physicians CAR
6410 Fannin St, Houston, TX 77030, USA
Site Contact
Recruiting
1,424 miles (2,291 km) awayfrom
New York City, New York
New York City, New York
View on Map
Instituto de Neurologia de Curitiba - Hospital Ecoville
Rua Jeremias Maciel Perretto, 300 - Campo Comprido, Curitiba - PR, 81210-310, Brazil
Recruiting
4,840 miles (7,789 km) awayfrom
New York City, New York
New York City, New York
View on Map
LHSC - University Hospital
339 Windermere Rd, London, ON N6A 5A5, Canada
Recruiting
406 miles (653 km) awayfrom
New York City, New York
New York City, New York
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Clinical Hospital Centre Rijeka
Krešimirova ul. 42, 51000, Rijeka, Croatia
Site Contact
Recruiting
4,240 miles (6,823 km) awayfrom
New York City, New York
New York City, New York
View on Map
Clinical Hospital Centar Zagreb
Kišpatićeva ul. 12, 10000, Zagreb, Croatia
Site Contact
Recruiting
4,288 miles (6,901 km) awayfrom
New York City, New York
New York City, New York
View on Map
CHU de Nice Hôpital Pasteur 2
30 Voie Romaine, 06000 Nice, France
Site Contact
Recruiting
3,986 miles (6,415 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hôpital de la Timone
278 Rue Saint-Pierre, 13005 Marseille, France
Site Contact
Recruiting
3,916 miles (6,302 km) awayfrom
New York City, New York
New York City, New York
View on Map
Universitaetsmedizin Goettingen
Robert-Koch-Straße 40, 37075 Göttingen, Germany
Site Contact
Recruiting
3,859 miles (6,211 km) awayfrom
New York City, New York
New York City, New York
View on Map
Universitaetsklinikum Leipzig AoeR
Liebigstraße 18, 04103 Leipzig, Germany
Site Contact
Recruiting
3,961 miles (6,375 km) awayfrom
New York City, New York
New York City, New York
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Recruiting
4,825 miles (7,764 km) awayfrom
New York City, New York
New York City, New York
View on Map
Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran
Vasco de Quiroga 15, Belisario Domínguez Secc 16, Tlalpan, 14080 Ciudad de México, CDMX, Mexico
Site Contact
Recruiting
2,099 miles (3,378 km) awayfrom
New York City, New York
New York City, New York
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Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie
Jaczewskiego 8, 20-954 Lublin, Poland
Site Contact
Recruiting
4,347 miles (6,996 km) awayfrom
New York City, New York
New York City, New York
View on Map
Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego
Dr. Stefana Kopcińskiego 22, 90-001 Łódź, Poland
Site Contact
Recruiting
4,215 miles (6,784 km) awayfrom
New York City, New York
New York City, New York
View on Map
Clinical Center Nis
Bulevar Dr Zorana Đinđića 48, Niš 18000, Serbia
Site Contact
Recruiting
4,627 miles (7,446 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Universitari de Bellvitge
Carrer de la Feixa Llarga, s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain
Recruiting
3,826 miles (6,158 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Universitari Vall d'Hebron
Passeig de la Vall d'Hebron, 119, 08035 Barcelona, Spain
Site Contact
Recruiting
3,826 miles (6,157 km) awayfrom
New York City, New York
New York City, New York
View on Map
Dokuz Eylul University Faculty of Medicine
İnciraltı, Otopark, 35330 Balçova/İzmir, Turkey
Recruitment Complete
5,044 miles (8,118 km) awayfrom
New York City, New York
New York City, New York
View on Map
Arizona Neuromuscular Research Center
4545 E Shea Blvd, Phoenix, AZ 85028, USA
Currently On Hold
2,132 miles (3,432 km) awayfrom
New York City, New York
New York City, New York
View on Map
HonorHealth Neurology
3501 N Scottsdale Rd Ste. 280A, Scottsdale, AZ 85251, USA
Currently On Hold
2,132 miles (3,431 km) awayfrom
New York City, New York
New York City, New York
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Currently On Hold
2,437 miles (3,923 km) awayfrom
New York City, New York
New York City, New York
View on Map
Forbes Norris Mda/als Ctr
1100 Van Ness Ave 6th Floor, San Francisco, CA 94109, USA
Site contact
Currently On Hold
2,566 miles (4,130 km) awayfrom
New York City, New York
New York City, New York
View on Map
Currently On Hold
1,000 miles (1,609 km) awayfrom
New York City, New York
New York City, New York
View on Map
William Beaumont Hospital
3601 W 13 Mile Rd, Royal Oak, MI 48073, USA
Currently On Hold
490 miles (789 km) awayfrom
New York City, New York
New York City, New York
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Hospital for Special Surgery
Hospital for Special Surgery, 535 E 70th St, New York, NY 10021, USA
Currently On Hold
1.48 miles (2.38 km) awayfrom
New York City, New York
New York City, New York
View on Map
Wake Forest University
1834 Wake Forest Rd, Winston-Salem, NC 27109, USA
Currently On Hold
467 miles (752 km) awayfrom
New York City, New York
New York City, New York
View on Map
Currently On Hold
569 miles (915 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Italiano
Pres. Tte. Gral. Juan Domingo Perón 4190, C1199 ABH, Buenos Aires, Argentina
Currently On Hold
5,301 miles (8,530 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Britanico de Buenos Aires
Perdriel 74, C1280 AEB, Buenos Aires, Argentina
Currently On Hold
5,303 miles (8,534 km) awayfrom
New York City, New York
New York City, New York
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Complejo Medico de la Policia Federal Argentina Churruca Visca
Uspallata 3400, C1437 CABA, Argentina
Currently On Hold
5,303 miles (8,534 km) awayfrom
New York City, New York
New York City, New York
View on Map
Instituto de Investigaciones Neurologicas Raul Carrea, FLENI
Montañeses 2325, C1428 AQK, Buenos Aires, Argentina
Currently On Hold
5,297 miles (8,524 km) awayfrom
New York City, New York
New York City, New York
View on Map
HUAP - UFF - Hospital Universitario Antonio Pedro - Universidade Federal Fluminense
R. Marquês de Paraná, 303 - Centro, Niterói - RJ, 24033-900, Brazil
Currently On Hold
4,824 miles (7,764 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital das Clínicas da Faculdade de Medicina da UNICAMP
R. Vital Brasil, 251 - Cidade Universitária, Campinas - SP, 13083-888, Brazil
Currently On Hold
4,721 miles (7,598 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital das Clínicas FMRP-USP
R. Ten. Catão Roxo, 3900 - Vila Monte Alegre, Ribeirão Preto - SP, 14015-010, Brazil
Currently On Hold
4,596 miles (7,396 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Sao Paulo
Hospital São Paulo - Vila Clementino, São Paulo - SP, 04039-000, Brazil
Currently On Hold
4,781 miles (7,694 km) awayfrom
New York City, New York
New York City, New York
View on Map
University of Alberta Hospital
8440 112 St NW, Edmonton, AB T6G 2B7, Canada
Currently On Hold
2,023 miles (3,255 km) awayfrom
New York City, New York
New York City, New York
View on Map
Toronto General Hospital
200 Elizabeth St, Toronto, ON M5G 2C4, Canada
Currently On Hold
341 miles (549 km) awayfrom
New York City, New York
New York City, New York
View on Map
Institucion Prestadora de Servicios de Salud de la Universidad de Antioquia "IPS UNIVERSITARIA"
Cl. 69 ##51c-24, Medellín, Antioquia, Colombia
Currently On Hold
2,385 miles (3,839 km) awayfrom
New York City, New York
New York City, New York
View on Map
University Hospital Centre "Sestre Milosrdnice"
Vinogradska cesta 29, 10000, Zagreb, Croatia
Currently On Hold
4,286 miles (6,898 km) awayfrom
New York City, New York
New York City, New York
View on Map
Fakultni nemocnice Brno
Jihlavská 340/20, 625 00 Brno-Bohunice-Brno-Starý Lískovec, Czechia
Currently On Hold
4,194 miles (6,750 km) awayfrom
New York City, New York
New York City, New York
View on Map
Fakultni nemocnice Ostrava
17. listopadu 1790, 708 00 Ostrava-Poruba, Czechia
Currently On Hold
4,233 miles (6,813 km) awayfrom
New York City, New York
New York City, New York
View on Map
Currently On Hold
4,077 miles (6,561 km) awayfrom
New York City, New York
New York City, New York
View on Map
Groupe Hospitalier Pellegrin - Hôpital Pellegrin
Place Amélie Raba Léon, 33076 Bordeaux, France
Currently On Hold
3,601 miles (5,795 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hopital Neurologique Pierre Wertheimer
59 Boulevard Pinel, 69500 Bron, France
Currently On Hold
3,819 miles (6,146 km) awayfrom
New York City, New York
New York City, New York
View on Map
Universitaetsklinikum Essen
Hufelandstraße 55, 45147 Essen, Germany
Currently On Hold
3,746 miles (6,029 km) awayfrom
New York City, New York
New York City, New York
View on Map
Chaim Sheba Medical Center
Derech Sheba 2, Ramat Gan, Israel
Currently On Hold
5,665 miles (9,117 km) awayfrom
New York City, New York
New York City, New York
View on Map
IRCCS Ospedale Casa Sollievo della Sofferenza
Viale Cappuccini, 1, 71013 San Giovanni Rotondo FG, Italy
Currently On Hold
4,426 miles (7,122 km) awayfrom
New York City, New York
New York City, New York
View on Map
Istituto Clinico Humanitas
Via Alessandro Manzoni, 56, 20089 Rozzano MI, Italy
Currently On Hold
4,015 miles (6,462 km) awayfrom
New York City, New York
New York City, New York
View on Map
Azienda Ospedaliera Universitaria Policlinico Tor Vergata
Viale Oxford, 81, 00133 Roma RM, Italy
Currently On Hold
4,285 miles (6,897 km) awayfrom
New York City, New York
New York City, New York
View on Map
Azienda Ospedaliero Universitaria San Martino
Largo Rosanna Benzi, 10, 16132 Genova GE, Italy
Currently On Hold
4,038 miles (6,498 km) awayfrom
New York City, New York
New York City, New York
View on Map
Azienda Ospedaliera Universitaria Policlinico G. Martino
Via Consolare Valeria, 1, 98124 Messina ME, Italy
Currently On Hold
4,552 miles (7,326 km) awayfrom
New York City, New York
New York City, New York
View on Map
Casa di Cura del Policlinico
Via Giuseppe Dezza, 48, 20144 Milano MI, Italy
Currently On Hold
4,012 miles (6,457 km) awayfrom
New York City, New York
New York City, New York
View on Map
Fondazione Istituto Neurologico Casimiro Mondino
Via Mondino, 2, 27100 Pavia PV, Italy
Currently On Hold
4,020 miles (6,469 km) awayfrom
New York City, New York
New York City, New York
View on Map
Azienda Ospedaliero Universitaria Pisana
Via Roma, 67, 56126 Pisa PI, Italy
Currently On Hold
4,123 miles (6,635 km) awayfrom
New York City, New York
New York City, New York
View on Map
Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza
Piazzale Aldo Moro, 3/5, 00185 Roma RM, Italy
Currently On Hold
4,279 miles (6,886 km) awayfrom
New York City, New York
New York City, New York
View on Map
Azienda Ospedaliera Città della Salute e della Scienza di Torino
Corso Bramante, 88, 10126 Torino TO, Italy
Currently On Hold
3,961 miles (6,375 km) awayfrom
New York City, New York
New York City, New York
View on Map
Azienda Ospedaliero-Universitaria Santa Maria della Misericordia
Piazzale Santa Maria della Misericordia, 15, 33100 Udine UD, Italy
Currently On Hold
4,164 miles (6,701 km) awayfrom
New York City, New York
New York City, New York
View on Map
Oslo Universitetssykehus HF, Ullevål
Bygg 19, Gaustad Sykehus, Sognsvannsveien 21, 0188 Oslo, Norway
Currently On Hold
3,670 miles (5,906 km) awayfrom
New York City, New York
New York City, New York
View on Map
COPERNICUS Podmiot Leczniczy Sp. z o. o.,
Nowe Ogrody 1-6, 80-803 Gdańsk, Poland
Currently On Hold
4,098 miles (6,594 km) awayfrom
New York City, New York
New York City, New York
View on Map
Currently On Hold
4,097 miles (6,593 km) awayfrom
New York City, New York
New York City, New York
View on Map
Currently On Hold
4,509 miles (7,256 km) awayfrom
New York City, New York
New York City, New York
View on Map
Currently On Hold
4,511 miles (7,259 km) awayfrom
New York City, New York
New York City, New York
View on Map
Currently On Hold
4,284 miles (6,895 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital de la Santa Creu i Sant Pau
Carrer de Sant Quintí, 89, 08041 Barcelona, Spain
Currently On Hold
3,828 miles (6,160 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Universitario Virgen del Rocio
Av. Manuel Siurot, S/n, 41013 Sevilla, Spain
Currently On Hold
3,562 miles (5,733 km) awayfrom
New York City, New York
New York City, New York
View on Map
Pamukkale Uni. Med. Fac.
Çamlaraltı, Pamukkale Ünv. Hastane Yolu, 20070 Kınıklı/Pamukkale/Denizli, Turkey
Currently On Hold
5,160 miles (8,305 km) awayfrom
New York City, New York
New York City, New York
View on Map
Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty
Cerrahpaşa, Koca Mustafapaşa Cd. No:53 D:No:53, 34096 Fatih/İstanbul, Turkey
Currently On Hold
5,009 miles (8,062 km) awayfrom
New York City, New York
New York City, New York
View on Map
Selcuk Universitesi Selcuklu Tip Fakultesi Hastanesi
Ardıçlı, Akademi, Celal Bayar Cd. No:313, 42250 Selçuklu/Konya, Turkey
Currently On Hold
5,288 miles (8,510 km) awayfrom
New York City, New York
New York City, New York
View on Map
Celal Bayar University Medical Faculty
Şehit Prof. Dr. İlhan Varank Kampüsü, Yağcılar, 45140 Yunusemre/Manisa, Turkey
Currently On Hold
5,044 miles (8,117 km) awayfrom
New York City, New York
New York City, New York
View on Map
Currently On Hold
3,357 miles (5,403 km) awayfrom
New York City, New York
New York City, New York
View on Map
King's College Hospital
Denmark Hill, Herne Hill, London SE5 9RS, UK
Currently On Hold
3,460 miles (5,568 km) awayfrom
New York City, New York
New York City, New York
View on Map
Currently On Hold
3,306 miles (5,320 km) awayfrom
New York City, New York
New York City, New York
View on Map
Neurology Center of Las Vegas
2480 Professional Ct, Las Vegas, NV 89128, USA
Terminated/Withdrawn
2,234 miles (3,594 km) awayfrom
New York City, New York
New York City, New York
View on Map
The Methodist Hospital Research Institute
6670 Bertner Ave, Houston, TX 77030, USA
Terminated/Withdrawn
1,424 miles (2,291 km) awayfrom
New York City, New York
New York City, New York
View on Map
Århus Universitetshospital
P. P. Ørums Gade 11, 8000 Aarhus, Denmark
Terminated/Withdrawn
3,744 miles (6,025 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hallands sjukhus
Lasarettsvägen, 302 33 Halmstad, Sweden
Terminated/Withdrawn
3,824 miles (6,154 km) awayfrom
New York City, New York
New York City, New York
View on Map
Kepler Universitätsklinikum
Krankenhausstraße 9, 4020 Linz, Austria
Terminated/Withdrawn
4,133 miles (6,652 km) awayfrom
New York City, New York
New York City, New York
View on Map
Vancouver General Hospital
899 W 12th Ave, Vancouver, BC V5Z 1M9, Canada
Terminated/Withdrawn
2,425 miles (3,903 km) awayfrom
New York City, New York
New York City, New York
View on Map
Recherche Sepmus, Inc.
4896 Boulevard Taschereau suite 250, Greenfield Park, QC J4V 2J2, Canada
Terminated/Withdrawn
327 miles (526 km) awayfrom
New York City, New York
New York City, New York
View on Map
Montreal Neurological Institute Clinical Research Unit
3801 Rue University, Montréal, QC H3A 2B4, Canada
Terminated/Withdrawn
328 miles (528 km) awayfrom
New York City, New York
New York City, New York
View on Map
Fundacion Oftalmologica de Santander - FOSCAL
Cl. 157 #23-99, Floridablanca, Santander, Colombia
Terminated/Withdrawn
2,329 miles (3,747 km) awayfrom
New York City, New York
New York City, New York
View on Map
Fundación Valle del Lili
Cra. 98 ## 18-49, Cali, Valle del Cauca, Colombia
Terminated/Withdrawn
2,588 miles (4,165 km) awayfrom
New York City, New York
New York City, New York
View on Map
Vseobecna fakultni nemocnice v Praze
U Nemocnice 499/2, 128 08 Praha 2-Nové Město, Czechia
Terminated/Withdrawn
4,080 miles (6,566 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hopital Purpan
9, 9 Place Lange, 31300 Toulouse, France
Terminated/Withdrawn
3,728 miles (6,000 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hopital Gui de Chauliac
80 Avenue Augustin Fliche, 38054 Montpellier, France
Terminated/Withdrawn
3,837 miles (6,174 km) awayfrom
New York City, New York
New York City, New York
View on Map
CHU Clermont Ferrand - Hopital Gabriel Montpied
58 Rue Montalembert, 63000 Clermont-Ferrand, France
Terminated/Withdrawn
3,740 miles (6,018 km) awayfrom
New York City, New York
New York City, New York
View on Map
Bezirksklinikum Regensburg
Universitätsstraße 84, 93053 Regensburg, Germany
Terminated/Withdrawn
4,022 miles (6,472 km) awayfrom
New York City, New York
New York City, New York
View on Map
Universitaetsklinikum Giessen und Marburg GmbH Standort Marburg
Baldingerstraße, 35043 Marburg, Germany
Terminated/Withdrawn
3,836 miles (6,173 km) awayfrom
New York City, New York
New York City, New York
View on Map
Universitaetsmedizin Rostock
Gehlsheimer Str. 20, 18147 Rostock, Germany
Terminated/Withdrawn
3,870 miles (6,228 km) awayfrom
New York City, New York
New York City, New York
View on Map
Universitaetsklinikum Duesseldorf AoeR
Universitätsklinikum Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany
Terminated/Withdrawn
3,745 miles (6,026 km) awayfrom
New York City, New York
New York City, New York
View on Map
Universitaetsklinikum Halle (Saale)
Ernst-Grube-Straße 40, 06120 Halle (Saale), Germany
Terminated/Withdrawn
3,938 miles (6,338 km) awayfrom
New York City, New York
New York City, New York
View on Map
Charité Universitaetsmedizin Berlin - Campus Charité Mitte
Charitépl. 1, 10117 Berlin, Germany
Terminated/Withdrawn
3,963 miles (6,377 km) awayfrom
New York City, New York
New York City, New York
View on Map
251 General Air Force Hospital
Leof. Panagioti Kanellopoulou, Athina 115 25, Greece
Terminated/Withdrawn
4,923 miles (7,923 km) awayfrom
New York City, New York
New York City, New York
View on Map
Athens Medical Center
Distomou 5-7, Marousi 151 25, Greece
Terminated/Withdrawn
4,922 miles (7,921 km) awayfrom
New York City, New York
New York City, New York
View on Map
Tel Aviv Sourasky Medical Center
Weizmann St 6, Tel Aviv-Yafo, Israel
Terminated/Withdrawn
5,661 miles (9,110 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Dr. Angel Leaño
Av. Dr. Angel Leaño 500, Los Robles, 45200 Nuevo México, Jal., Mexico
Terminated/Withdrawn
2,209 miles (3,556 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Central Dr Ignacio Morones Prieto
Av Venustiano Carranza S/N, Zona Universitaria, 78290 San Luis, S.L.P., Mexico
Terminated/Withdrawn
2,033 miles (3,271 km) awayfrom
New York City, New York
New York City, New York
View on Map
Complejo Hospitalario Universitario de Santiago
Rúa da Choupana, s/n, 15706 Santiago de Compostela, A Coruña, Spain
Terminated/Withdrawn
3,284 miles (5,285 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Universitario Ramon y Cajal
M-607, km. 9, 100, 28034 Madrid, Spain
Terminated/Withdrawn
3,580 miles (5,761 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Universitario La Paz
Paseo de la Castellana, 261, 28046 Madrid, Spain
Terminated/Withdrawn
3,580 miles (5,762 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Universitari i Politecnic La Fe
Avinguda de Fernando Abril Martorell, 106, 46026 València, Valencia, Spain
Terminated/Withdrawn
3,769 miles (6,066 km) awayfrom
New York City, New York
New York City, New York
View on Map
Hospital Universitario Miguel Servet
Paseo Isabel la Católica, 1-3, 50009 Zaragoza, Spain
Terminated/Withdrawn
3,678 miles (5,919 km) awayfrom
New York City, New York
New York City, New York
View on Map
Sahlgrenska universitetssjukhuset
Blå stråket 5, 413 45 Göteborg, Sweden
Terminated/Withdrawn
3,767 miles (6,062 km) awayfrom
New York City, New York
New York City, New York
View on Map
Universitaetsspital Zuerich
Rämistrasse 100, 8091 Zürich, Switzerland
Terminated/Withdrawn
3,926 miles (6,319 km) awayfrom
New York City, New York
New York City, New York
View on Map
Uludag University Medical Faculty
Özlüce Görükle Kampüsü, Özlüce, 16059 Nilüfer/Bursa, Turkey
Terminated/Withdrawn
5,041 miles (8,113 km) awayfrom
New York City, New York
New York City, New York
View on Map
Bezmialem Vakif
Adnan Menderes Bulvarı, Topkapı, Vatan Caddesi, 34093 Fatih/İstanbul, Turkey
Terminated/Withdrawn
5,009 miles (8,061 km) awayfrom
New York City, New York
New York City, New York
View on Map
Marmara University Pendik Research and Training Hospital
Fevzi Çakmak, Muhsin Yazıcıoğlu Cd No:10, 34899 Pendik/İstanbul, Turkey
Terminated/Withdrawn
5,028 miles (8,091 km) awayfrom
New York City, New York
New York City, New York
View on Map
View all (113)
Trial Protocol ID: 161403
Back to Trial Summary