ADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD)

IDENTIFIERS
Trial Protocol: 061001
Clinicaltrials.gov: NCT02078427
PURPOSE

The purpose of the study is to document the natural history of hemophilia A disease and long-term outcomes in terms of effectiveness, safety and quality of life in participants receiving Antihemophilic Factor (Recombinant) - Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) - Pegylated (rAHF-PEG) in routine clinical practice

Recruiting
AU
AT
BE
20+
BR
BG
CA
CN
CO
CZ
DK
FR
GR
HU
IT
NO
PL
PT
RU
SI
ES
SE
CH
GB

Trial at a glance

What medical condition is being studied?   Hemophilia A
What is the trial testing?   ADVATE, ADYNOVI
How many participants are being enrolled?   1130
When is the trial being conducted?    - 
How long is participation in the trial?   a. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) alone b. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) alone with a minimum follow up time of 4 years c. Up to approximately 12 years for currently enrolled subjects treated with rAHF-PFM and subsequently switched to rAHF-PEG (i.e. up to approx. 8 years on rAHF-PFM and at least 4 years on rAHF-PEG)

Key requirements

Sex   
All
Age   
All
Accepts Healthy Volunteers?   
No

Trial Details / Participation Requirements

CLICK TO EXPANDCLICK TO COLLAPSE
Trial Type:   Observational
Trial Arms/Groups or Cohorts:   
rAHF-PFM: Participants treated with rAHF-PFM alone
rAHF-PEG: Participants treated with rAHF-PEG alone
rAHF-PFM then rAHF-PEG: Participants treated with rAHF-PFM and subsequently switched to rAHF-PEG
Intervention:   ADVATE, ADYNOVI
Primary Outcome Measure(s):
Joint Health Outcomes - Assessed by Physical Exam Using Only the Pain, Bleeding, and Physical Exam Parameters of the Gilbert Scale [Time Frame: Up to approximately 12 years]
Secondary Outcome Measure(s):   
Annualized Bleed Rate, All Joints [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized Bleed Rate, All Bleeds [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized bleed rate, pre-existing target joints at baseline [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of New Target Joints [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health by X-ray by Pettersson scale [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit.]
Status of Joint Health by Magnetic Resonance Imaging (MRI) Scoring System- Using The Lund Scoring System (LSS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health using the Hemophilia Joint Health Score (HJHS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for prophylaxis therapy [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Compliance with the dosing prescribed and its relationship with effectiveness [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Global effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG units required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG infusions required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of target joint intervention, including surgery, radiosynovectomy, and chemosynovectomy [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of pseudo tumor development [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: HAL questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-12v2 questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D questionnaire - for adult patients [Time Frame: Enrollment visit;Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: PedHAL questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-10 questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D (14 and up) questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Chronic pain associated with hemophilia, as measured over a period of 4 weeks on an annual basis, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Acute pain associated with hemophilia, as measured with individual bleeding episodes, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Number of days lost from school or work due to bleeding episodes [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 1 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 2 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels Lesser than (<)1%, Lesser Than or Equal to (<=) 2%, and <= 5% without history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% with history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Untreated Patient (PUPs) and Minimally Treated Patients (MTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related non-serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of inhibitors after switching to rAHF-PEG [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Entry Criteria:
Inclusion Criteria: - Participant has hemophilia A {FVIII lesser than or equal to (<=)5%} - Participant is prescribed Antihemophilic Factor (Recombinant) - Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) - Pegylated (rAHF-PEG) by the treating physician - Participant or participant's legally authorized representative provides informed consent Exclusion Criteria: - Participant has known hypersensitivity to the active substance or any of the excipients - Participant has known allergic reaction to mouse or hamster proteins - Participant has participated in another clinical study involving an investigational product (IP) or device within 30 days prior to study enrollment or is scheduled to participate in another clinical study involving another FVIII concentrate or device during the course of this study

Trial Locations

Any
Terminated
Completed
Recruiting
Withdrawn
Any
RESULTS
Medizinische Universitaet Wien

Spitalgasse 23, 1090 Wien, Austria

Recruiting
4,524 miles (7,280 km)  awayfrom
Canada
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Hemoce - Ce

Av. José Bastos, 3390 - Rodolfo Teófilo, Fortaleza - CE, 60431-086, Brazil

Recruiting
5,564 miles (8,954 km)  awayfrom
Canada
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Hemocentro do Espírito Santo

Av. Mal. Campos, 1468 - Nazareth, Vitória - ES, 29047-105, Brazil

Site Contact
Recruiting
6,479 miles (10,427 km)  awayfrom
Canada
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Hemepar - Pr

Tv. João Prosdócimo, 145 - Alto da XV, Curitiba - PR, 80045-145, Brazil

Recruiting
6,505 miles (10,469 km)  awayfrom
Canada
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Hemorgs - Rs

Av. Bento Gonçalves, 3722 - Partenon, Porto Alegre - RS, 90650-001, Brazil

Recruiting
6,733 miles (10,836 km)  awayfrom
Canada
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Hemocentro da UNICAMP

Universidade Estadual de Campinas - R. Carlos Chagas, 480 - Cidade Universitária, Campinas - SP, 13083-878, Brazil

Recruiting
6,414 miles (10,322 km)  awayfrom
Canada
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Hemocentro Ribeirão Preto - SP

Rua Tenente Catão Roxo, 2501 Entrada pela - R. Prof. Hélio Lourenço - Vila Monte Alegre, Ribeirão Preto - SP, 14051-060, Brazil

Recruiting
6,288 miles (10,120 km)  awayfrom
Canada
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Hemorio - Rj

R. Frei Caneca, 8 - Centro, Rio de Janeiro - RJ, 20211-030, Brazil

Recruiting
6,540 miles (10,525 km)  awayfrom
Canada
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Faculdade de Medicina da Universidade de São Paulo

Pacaembu, São Paulo - State of São Paulo, 05403, Brazil

Recruiting
6,470 miles (10,412 km)  awayfrom
Canada
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Children's Hospital of Eastern Ontario

401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Recruiting
1,482 miles (2,385 km)  awayfrom
Canada
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St-Michael's Hospital

30 Bond St, Toronto, ON M5B 1W8, Canada

Site Contact
Recruiting
1,426 miles (2,295 km)  awayfrom
Canada
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Sick Kids Hospital

555 University Ave, Toronto, ON M5G 1X8, Canada

Recruiting
1,425 miles (2,294 km)  awayfrom
Canada
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Royal University Hospital

103 Hospital Dr, Saskatoon, SK S7N 0W8, Canada

Recruiting
241 miles (389 km)  awayfrom
Canada
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Shenzhen Children's Hospital

Mintian Rd, Fu Tian C B D, Futian Qu, Shenzhen Shi, Guangdong Sheng, China

Recruiting
6,554 miles (10,547 km)  awayfrom
Canada
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Nanfang Hospital Affiliated to Nanfang Medical University

1838 Guangzhou N Ave, Baiyun Qu, Guangzhou Shi, Guangdong Sheng, China

Site Contact
Recruiting
6,529 miles (10,507 km)  awayfrom
Canada
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Institute of Hematology, Blood Disease Hospital, PUMC&CAMS

Heping, Tianjin, China

Site Contact
Recruiting
5,423 miles (8,727 km)  awayfrom
Canada
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Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology

China, Hubei Sheng, Wuhan Shi, Jiangan Qu, 三阳路

Site Contact
Recruiting
6,030 miles (9,704 km)  awayfrom
Canada
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The Affiliated Hospital of Xuzhou Medical University

Yunlong District, Xuzhou, China

Site Contact
Recruiting
5,730 miles (9,222 km)  awayfrom
Canada
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The Blood Center of Shandong Province

Jinan, Shandong, China

Recruiting
5,581 miles (8,982 km)  awayfrom
Canada
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Beijing Children's Hospital Affiliated to Capital University of Medical Sciences

Fengtai District, China

Recruiting
5,393 miles (8,679 km)  awayfrom
Canada
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Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

321 Zhongshan Rd, Gulou Qu, Nanjing Shi, Jiangsu Sheng, China, 210008

Site Contacts
Recruiting
5,836 miles (9,392 km)  awayfrom
Canada
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Shenzhen Second People's Hospital

3002 Sungang W Rd, Futian Qu, Shenzhen Shi, Guangdong Sheng, China

Recruiting
6,552 miles (10,545 km)  awayfrom
Canada
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Integral Solutions SD SAS

Cra 7 No. 156-68 Edificio North Point Torre 3 Piso 33, Bogotá, Colombia

Recruiting
3,926 miles (6,319 km)  awayfrom
Canada
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Fundación Oftalmológica de Santander FOSCAL

Cl. 157 #23-99, Floridablanca, Santander, Colombia

Recruiting
3,799 miles (6,113 km)  awayfrom
Canada
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Fakultní nemocnice Ostrava, Krevní centrum

17. listopadu 833/9, 708 00 Ostrava-Poruba, Czechia

Recruiting
4,472 miles (7,197 km)  awayfrom
Canada
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Fakultní nemocnice v Motole

V Úvalu 84, 150 06 Praha 5, Czechia

Recruiting
4,367 miles (7,028 km)  awayfrom
Canada
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CHU Côte de Nacre - CRTH

Avenue de la Côte de Nacre, 14000 Caen, France

Recruiting
4,023 miles (6,474 km)  awayfrom
Canada
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CIC

2 Allée des Artilleurs, 42000 Saint-Étienne, France

Recruiting
4,363 miles (7,022 km)  awayfrom
Canada
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Aghia Sofia Children's Hospital

Thivon 1, Athina 115 27, Greece

Recruiting
5,323 miles (8,566 km)  awayfrom
Canada
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General Hospital of Thessaloniki "Ippokratio"

Konstantinoupoleos 49, Thessaloniki 546 42, Greece

Site Contact
Recruiting
5,141 miles (8,274 km)  awayfrom
Canada
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Heim Pál Gyermekkórház

Budapest, Üllői út 86, 1089 Hungary

Recruiting
4,633 miles (7,456 km)  awayfrom
Canada
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Debreceni Egyetem Klinikai Kozpont

Debrecen, Nagyerdei krt. 98, 4032 Hungary

Recruiting
4,687 miles (7,543 km)  awayfrom
Canada
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Mohács City Hospital

Mohács, Szepessy tér 7, 7700 Hungary

Recruiting
4,712 miles (7,583 km)  awayfrom
Canada
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Azienda Ospedaliera Policlinico Consorziale Di Bari

Piazza Giulio Cesare, 11, 70124 Bari BA, Italy

Recruiting
4,958 miles (7,979 km)  awayfrom
Canada
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Policlinico S Orsola Malpighi

Via Giuseppe Massarenti, 9, 40138 Bologna BO, Italy

Recruiting
4,613 miles (7,424 km)  awayfrom
Canada
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Ospedale Pugliese -Ciaccio

Viale Papa Pio X, 83, 88100 Catanzaro CZ, Italy

Recruiting
5,082 miles (8,178 km)  awayfrom
Canada
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Ospedale di Macerata

Via Santa Lucia, 2, 62100 Macerata MC, Italy

Recruiting
4,739 miles (7,627 km)  awayfrom
Canada
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Via della Commenda, 10, 20122 Milano MI, Italy

Recruiting
4,499 miles (7,240 km)  awayfrom
Canada
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Azienda Ospedaliera Universitaria Federico II

Via Sergio Pansini, 5, 80131 Napoli NA, Italy

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Recruiting
4,902 miles (7,890 km)  awayfrom
Canada
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Azienda Ospedaliera di Padova Clinica Medica II

Via Gustavo Modena, 9, 35128 Padova PD, Italy

Recruiting
4,575 miles (7,362 km)  awayfrom
Canada
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AOUP P. Giaccone

Via del Vespro, 129, 90127 Palermo PA, Italy

Recruiting
5,042 miles (8,115 km)  awayfrom
Canada
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Azienda Ospedaliera Bianchi Melacrino Morelli

Via Giuseppe Melacrino, 21, 89124 Reggio Calabria RC, Italy

Recruiting
5,105 miles (8,216 km)  awayfrom
Canada
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Università degli studi di Roma "La Sapienza"

Viale Regina Elena, 334, 00161 Roma RM, Italy

Recruiting
4,795 miles (7,717 km)  awayfrom
Canada
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Ospedale Pediatrico Bambino Gesù

Piazza di Sant'Onofrio, 4, 00165 Roma RM, Italy

Site contact
Recruiting
4,794 miles (7,715 km)  awayfrom
Canada
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Centro Emofilia e Coagulopatie Rare

73020 Scorrano, Province of Lecce, Italy

Recruiting
5,058 miles (8,139 km)  awayfrom
Canada
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Ospedale Molinette

Via Cherasco, 15, 10126 Torino TO, Italy

Recruiting
4,481 miles (7,211 km)  awayfrom
Canada
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SBHI Chelyabinsk Regional Children's Clinical Hospital

Chelyabinsk, Chelyabinsk Oblast, Russia

Site Contact
Recruiting
4,750 miles (7,645 km)  awayfrom
Canada
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SBHI of the Republic of Kareliya Republican Hospital n.a. V.A. Baranov

Petrozavodsk, Republic of Karelia, Russia

Recruiting
4,045 miles (6,510 km)  awayfrom
Canada
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State Budget Healthcare Institution of Saint-Petersburg "City polyclinic #37"

St Petersburg, Russia, 191186

Recruiting
4,099 miles (6,597 km)  awayfrom
Canada
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Clinics of FSBEI High Education Samara SMU of MoH of Russia

Ulitsa Artsybushevskaya, 171, Samara, Samarskaya oblast', Russia, 443001

Recruiting
4,796 miles (7,718 km)  awayfrom
Canada
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Hospital Universitari Vall d'Hebron (HUVH)

Passeig de la Vall d'Hebron, 119, 08035 Barcelona, Spain

Recruiting
4,521 miles (7,276 km)  awayfrom
Canada
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Hospital Hospital Sant Joan de Déu

Hospital Sant Joan de Déu, 08950, Barcelona, Spain

Recruiting
4,522 miles (7,278 km)  awayfrom
Canada
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Hospital Universitario Son Espases

Carretera de Valldemossa, 79, 07120 Palma, Illes Balears, Spain

Recruiting
4,639 miles (7,465 km)  awayfrom
Canada
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Karolinska Universitetssjukhuset Solna

Karolinska Vägen 22, 171 64 Solna, Sweden

Recruiting
3,915 miles (6,300 km)  awayfrom
Canada
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Universitätsspital Zürich

Rämistrasse 100, 8091 Zürich, Switzerland

Recruiting
4,372 miles (7,037 km)  awayfrom
Canada
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Hampshire Hospitals NHS Foundation Trust, Basingstoke and North Hampshire Hospital

Aldermaston Rd, Basingstoke RG24 9NA, UK

Recruiting
3,892 miles (6,264 km)  awayfrom
Canada
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East Kent Hospitals University Foundation Trust, Kent & Canterbury Hospital

Ethelbert Rd, Canterbury CT1 3NG, UK

Recruiting
3,955 miles (6,365 km)  awayfrom
Canada
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Great Ormond Street Hospital for Children NHS Trust

Great Ormond Street, Holborn, London WC1N 3JH, UK

Recruiting
3,908 miles (6,289 km)  awayfrom
Canada
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Landes Frauen und Kinderklinik Linz (LFKK Linz)

Landes-Kinderklinik, Krankenhausstraße, 4020 Linz, Austria

Completed
4,469 miles (7,192 km)  awayfrom
Canada
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Fundação HEMOPA

Tv. Padre Eutíquio, 2109 - Batista Campos, Belém - PA, 66033-000, Brazil

Completed
5,076 miles (8,169 km)  awayfrom
Canada
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Hôpital de la Mère et de l'Enfant - CHU de LIMOGES

8 Avenue Dominique Larrey, 87000 Limoges, France

Completed
4,252 miles (6,843 km)  awayfrom
Canada
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Laikon General Hospital

Goudi, Athens 115 27, Greece

Completed
5,323 miles (8,566 km)  awayfrom
Canada
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Azienda Ospedaliera Universitaria Vittorio Emanuele, Ferrarotto, S. Bambino

Via Salvatore Citelli, 1, 95124 Catania CT, Italy

Completed
5,125 miles (8,248 km)  awayfrom
Canada
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Az. Osp. Univ. Careggi

Largo Piero Palagi, 1, 50139 Firenze FI, Italy

Completed
4,650 miles (7,483 km)  awayfrom
Canada
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Rikshospitalet

Sognsvannsveien 20, 0372 Oslo, Norway

Completed
3,730 miles (6,003 km)  awayfrom
Canada
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Hospital do Divino Espírito Santo

Av. D. Manuel I, 9500-370 Ponta Delgada, Portugal

Completed
3,759 miles (6,049 km)  awayfrom
Canada
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Centro Hospitalar e Universitade de Coimbra

Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal

Completed
4,247 miles (6,835 km)  awayfrom
Canada
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Inselspital Bern

Freiburgstrasse 18, 3010 Bern, Switzerland

Completed
4,366 miles (7,026 km)  awayfrom
Canada
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Royal Prince Alfred Hospital

50 Missenden Rd, Camperdown NSW 2050, Australia

Terminated/Withdrawn
8,600 miles (13,840 km)  awayfrom
Canada
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South Metropolitan Health Service trading as Fiona Stanley Hospital

14 Barry Marshall Parade, Murdoch WA 6150, Australia

Terminated/Withdrawn
9,864 miles (15,874 km)  awayfrom
Canada
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Kepler Universitätsklinikum Klinik für Kinder-und Jugendheilkunde

Krankenhausstraße 9, 4020 Linz, Austria

Terminated/Withdrawn
4,469 miles (7,192 km)  awayfrom
Canada
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Cliniques Universitaires Saint-Luc

Avenue Hippocrate 10, 1200 Bruxelles, Belgium

Terminated/Withdrawn
4,069 miles (6,549 km)  awayfrom
Canada
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Stollery Children's Hospital, University of Alberta

Edmonton, AB T6G 2B7, Canada

Terminated/Withdrawn
342 miles (551 km)  awayfrom
Canada
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The Moncton City Hospital

135 Macbeath Ave, Moncton, NB E1C 6Z8, Canada

Terminated/Withdrawn
1,870 miles (3,010 km)  awayfrom
Canada
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Fakultní nemocnice Brno

Jihlavská 340/20, 625 00 Brno-Bohunice-Brno-Starý Lískovec, Czechia

Terminated/Withdrawn
4,473 miles (7,198 km)  awayfrom
Canada
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Fakultní nemocnice Ostrava, Oddělení dětské hematologie a hematoonkologie

17. listopadu 1790, 708 00 Ostrava-Poruba, Czechia

Terminated/Withdrawn
4,472 miles (7,197 km)  awayfrom
Canada
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Rigshospitalet

Blegdamsvej 9, 2100 København, Denmark

Terminated/Withdrawn
4,005 miles (6,445 km)  awayfrom
Canada
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"Hôpital Morvan CHRU de Brest"

2 Avenue Foch, 29200 Brest, France

Terminated/Withdrawn
3,943 miles (6,346 km)  awayfrom
Canada
View on Map
Centre Hospitalier Générale - CTH

Maternité, Rue Lucien Biset, 73000 Chambéry, France

Terminated/Withdrawn
4,401 miles (7,083 km)  awayfrom
Canada
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CTRH - CHU Bocage

21000 Dijon, France

Terminated/Withdrawn
4,279 miles (6,886 km)  awayfrom
Canada
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Hôpital André Mignot

177 Rue de Versailles, 78150 Le Chesnay, France

Terminated/Withdrawn
4,114 miles (6,621 km)  awayfrom
Canada
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CHRU Hôtel Dieu - CRTH

1 Place Alexis-Ricordeau, 44093 Nantes, France

Terminated/Withdrawn
4,094 miles (6,588 km)  awayfrom
Canada
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Hôpital Cochin

27 Rue du Faubourg Saint-Jacques, 75014 Paris, France

Terminated/Withdrawn
4,120 miles (6,630 km)  awayfrom
Canada
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CHU de Reims Hôpital Maison Blanche - CRTH

45 Rue Cognacq-Jay, 51092 Reims, France

Terminated/Withdrawn
4,146 miles (6,672 km)  awayfrom
Canada
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Centre Régional de Traitement de l'Hémophilie et des Maladies hémorragiques. CHU de Rennes - Hôpital Pontchaillou

2 Rue Henri le Guilloux, 35000 Rennes, France

Terminated/Withdrawn
4,041 miles (6,504 km)  awayfrom
Canada
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CHRU Charles Nicolle

37 Boulevard Gambetta, 76000 Rouen, France

Terminated/Withdrawn
4,053 miles (6,522 km)  awayfrom
Canada
View on Map
CHRU Purpan CRTH - Pavillon Sénac

9, 9 Place Lange, 31300 Toulouse, France

Terminated/Withdrawn
4,379 miles (7,048 km)  awayfrom
Canada
View on Map
Jósa András County Hospital

Nyíregyháza, Jósa András u., 4400 Hungary

Terminated/Withdrawn
4,665 miles (7,508 km)  awayfrom
Canada
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Markusovszky Hospital

Szombathely, Markusovszky Lajos u. 5, 9700 Hungary

Terminated/Withdrawn
4,588 miles (7,384 km)  awayfrom
Canada
View on Map
Policlinico Universitario Gemelli

Via della Pineta Sacchetti, 217, 00168 Roma RM, Italy

Terminated/Withdrawn
4,791 miles (7,710 km)  awayfrom
Canada
View on Map
Rikshospitalet, Oslo University Hospital

Sognsvannsveien 20, 0372 Oslo, Norway

Terminated/Withdrawn
3,730 miles (6,003 km)  awayfrom
Canada
View on Map
Szpital Uniwersytecki nr 1 im. dr Andrzeja Jurasza

Marii Skłodowskiej Curie 9, 85-094 Bydgoszcz, Poland

Terminated/Withdrawn
4,275 miles (6,880 km)  awayfrom
Canada
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Samodzielny Publiczny Szpital Kliniczny nr 1

Gdańsk, Poland

Terminated/Withdrawn
4,217 miles (6,786 km)  awayfrom
Canada
View on Map
Samodzielny Publiczny Dzieciecy Szpital Kliniczny

Żwirki i Wigury 63A, 02-091 Warszawa, Poland

Terminated/Withdrawn
4,394 miles (7,071 km)  awayfrom
Canada
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Uniwersytecki Szpital Kliniczny we Wrocławiu

Borowska 213, 50-556 Wrocław, Poland

Terminated/Withdrawn
4,372 miles (7,037 km)  awayfrom
Canada
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Centro Hospitalar Lisboa Norte Hospital de Sta. Maria

Av. Prof. Egas Moniz MB, 1649-028 Lisboa, Portugal

Terminated/Withdrawn
4,300 miles (6,920 km)  awayfrom
Canada
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Centro Hospitalar de São João, E.P.E.

Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

Terminated/Withdrawn
4,190 miles (6,743 km)  awayfrom
Canada
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Federal State Budget Institution "Hematology Research Center" of Ministry of Healthcare of Russian Federation

Moscow, Russia, 125167

Terminated/Withdrawn
4,469 miles (7,192 km)  awayfrom
Canada
View on Map
University Medical Centre Ljubljana

Zaloška cesta 7, 1000 Ljubljana, Slovenia

Terminated/Withdrawn
4,605 miles (7,411 km)  awayfrom
Canada
View on Map
Hospital Teresa Herrera-Materno Infantil

As, Xubias de Abaixo, s/n, 15009 A Coruña, Spain

Terminated/Withdrawn
4,083 miles (6,572 km)  awayfrom
Canada
View on Map
Sahlgrenska University Hospital

Blå stråket 5, 413 45 Göteborg, Sweden

Terminated/Withdrawn
3,881 miles (6,246 km)  awayfrom
Canada
View on Map
Kliniska studier i Sverige - Forum Söder

Skånes universitetssjukhus, Akutgatan 8, 221 85 Lund, Sweden

Terminated/Withdrawn
4,019 miles (6,467 km)  awayfrom
Canada
View on Map
Universitätsspital Basel

Universitätsspital CH, Petersgraben 4, 4031 Basel, Switzerland

Terminated/Withdrawn
4,336 miles (6,978 km)  awayfrom
Canada
View on Map
Centre Hospitalier Universitaire Vaudois

Rue du Bugnon 46, 1011 Lausanne, Switzerland

Terminated/Withdrawn
4,368 miles (7,030 km)  awayfrom
Canada
View on Map
Luzerner Kantonsspital

Spitalstrasse, 6004 Luzern, Switzerland

Terminated/Withdrawn
4,384 miles (7,055 km)  awayfrom
Canada
View on Map
Kantonsspital St. Gallen

Rorschacher Str. 95, 9001 St. Gallen, Switzerland

Terminated/Withdrawn
4,392 miles (7,068 km)  awayfrom
Canada
View on Map
FMH Kinder und Jugendmedizin, im Wabern-Zentrum

Wabern bei Bern, 3084 Köniz, Switzerland

Terminated/Withdrawn
4,368 miles (7,029 km)  awayfrom
Canada
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Kinderspital Zürich

Steinwiesstrasse 75, 8032 Zürich, Switzerland

Terminated/Withdrawn
4,373 miles (7,038 km)  awayfrom
Canada
View on Map
Cambridge University Hospital NHS Foundation Trust, Addenbrooke's Hospital

Hills Rd, Cambridge CB2 0QQ, UK

Terminated/Withdrawn
3,881 miles (6,245 km)  awayfrom
Canada
View on Map
UMHAP Sveti Georgï EAD

Plovdiv, Bulgaria

Terminated/Withdrawn
5,089 miles (8,190 km)  awayfrom
Canada
View on Map
The Affiliated Hospital of Medical College, Qingdao University

16 Jiangsu Rd, Shinan Qu, Qingdao Shi, Shandong Sheng, China

Terminated/Withdrawn
5,547 miles (8,927 km)  awayfrom
Canada
View on Map
CHRU Pellegrin

33076 Bordeaux, France

Terminated/Withdrawn
4,250 miles (6,840 km)  awayfrom
Canada
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View all (112)
Trial Protocol ID: 061001
Back to Trial Summary