ADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD)

IDENTIFIERS
Trial Protocol: 061001
Clinicaltrials.gov: NCT02078427
PURPOSE

The purpose of the study is to document the natural history of hemophilia A disease and long-term outcomes in terms of effectiveness, safety and quality of life in participants receiving Antihemophilic Factor (Recombinant) - Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) - Pegylated (rAHF-PEG) in routine clinical practice

Recruiting
AU
AT
BE
20+
BR
BG
CA
CN
CO
CZ
DK
FR
GR
HU
IT
NO
PL
PT
RU
SI
ES
SE
CH
GB

Trial at a glance

What medical condition is being studied?   Hemophilia A
What is the trial testing?   ADVATE, ADYNOVI
How many participants are being enrolled?   1130
When is the trial being conducted?    - 
How long is participation in the trial?   a. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) alone b. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) alone with a minimum follow up time of 4 years c. Up to approximately 12 years for currently enrolled subjects treated with rAHF-PFM and subsequently switched to rAHF-PEG (i.e. up to approx. 8 years on rAHF-PFM and at least 4 years on rAHF-PEG)

Key requirements

Sex   
All
Age   
All
Accepts Healthy Volunteers?   
No

Trial Details / Participation Requirements

CLICK TO EXPANDCLICK TO COLLAPSE
Trial Type:   Observational
Trial Arms/Groups or Cohorts:   
rAHF-PFM: Participants treated with rAHF-PFM alone
rAHF-PEG: Participants treated with rAHF-PEG alone
rAHF-PFM then rAHF-PEG: Participants treated with rAHF-PFM and subsequently switched to rAHF-PEG
Intervention:   ADVATE, ADYNOVI
Primary Outcome Measure(s):
Joint Health Outcomes - Assessed by Physical Exam Using Only the Pain, Bleeding, and Physical Exam Parameters of the Gilbert Scale [Time Frame: Up to approximately 12 years]
Secondary Outcome Measure(s):   
Annualized Bleed Rate, All Joints [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized Bleed Rate, All Bleeds [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized bleed rate, pre-existing target joints at baseline [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of New Target Joints [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health by X-ray by Pettersson scale [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit.]
Status of Joint Health by Magnetic Resonance Imaging (MRI) Scoring System- Using The Lund Scoring System (LSS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health using the Hemophilia Joint Health Score (HJHS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for prophylaxis therapy [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Compliance with the dosing prescribed and its relationship with effectiveness [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Global effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG units required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG infusions required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of target joint intervention, including surgery, radiosynovectomy, and chemosynovectomy [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of pseudo tumor development [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: HAL questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-12v2 questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D questionnaire - for adult patients [Time Frame: Enrollment visit;Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: PedHAL questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-10 questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D (14 and up) questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Chronic pain associated with hemophilia, as measured over a period of 4 weeks on an annual basis, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Acute pain associated with hemophilia, as measured with individual bleeding episodes, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Number of days lost from school or work due to bleeding episodes [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 1 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 2 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels Lesser than (<)1%, Lesser Than or Equal to (<=) 2%, and <= 5% without history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% with history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Untreated Patient (PUPs) and Minimally Treated Patients (MTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related non-serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of inhibitors after switching to rAHF-PEG [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Entry Criteria:
Inclusion Criteria: - Participant has hemophilia A {FVIII lesser than or equal to (<=)5%} - Participant is prescribed Antihemophilic Factor (Recombinant) - Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) - Pegylated (rAHF-PEG) by the treating physician - Participant or participant's legally authorized representative provides informed consent Exclusion Criteria: - Participant has known hypersensitivity to the active substance or any of the excipients - Participant has known allergic reaction to mouse or hamster proteins - Participant has participated in another clinical study involving an investigational product (IP) or device within 30 days prior to study enrollment or is scheduled to participate in another clinical study involving another FVIII concentrate or device during the course of this study

Trial Locations

Any
Terminated
Completed
Recruiting
Withdrawn
Any
RESULTS
Medizinische Universitaet Wien

Spitalgasse 23, 1090 Wien, Austria

Recruiting
2,783 miles (4,478 km)  awayfrom
Новосибирск, Новосибирская область
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Hemoce - Ce

Av. José Bastos, 3390 - Rodolfo Teófilo, Fortaleza - CE, 60431-086, Brazil

Recruiting
7,642 miles (12,299 km)  awayfrom
Новосибирск, Новосибирская область
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Hemocentro do Espírito Santo

Av. Mal. Campos, 1468 - Nazareth, Vitória - ES, 29047-105, Brazil

Site Contact
Recruiting
8,662 miles (13,940 km)  awayfrom
Новосибирск, Новосибирская область
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Hemepar - Pr

Tv. João Prosdócimo, 145 - Alto da XV, Curitiba - PR, 80045-145, Brazil

Recruiting
9,284 miles (14,941 km)  awayfrom
Новосибирск, Новосибирская область
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Hemorgs - Rs

Av. Bento Gonçalves, 3722 - Partenon, Porto Alegre - RS, 90650-001, Brazil

Recruiting
9,609 miles (15,465 km)  awayfrom
Новосибирск, Новосибирская область
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Fundação HEMOPA

Tv. Padre Eutíquio, 2109 - Batista Campos, Belém - PA, 66033-000, Brazil

Recruiting
7,846 miles (12,627 km)  awayfrom
Новосибирск, Новосибирская область
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Hemocentro da UNICAMP

Universidade Estadual de Campinas - R. Carlos Chagas, 480 - Cidade Universitária, Campinas - SP, 13083-878, Brazil

Recruiting
9,057 miles (14,576 km)  awayfrom
Новосибирск, Новосибирская область
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Hemocentro Ribeirão Preto - SP

Rua Tenente Catão Roxo, 2501 Entrada pela - R. Prof. Hélio Lourenço - Vila Monte Alegre, Ribeirão Preto - SP, 14051-060, Brazil

Recruiting
8,992 miles (14,472 km)  awayfrom
Новосибирск, Новосибирская область
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Hemorio - Rj

R. Frei Caneca, 8 - Centro, Rio de Janeiro - RJ, 20211-030, Brazil

Recruiting
8,916 miles (14,350 km)  awayfrom
Новосибирск, Новосибирская область
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Faculdade de Medicina da Universidade de São Paulo

Pacaembu, São Paulo - State of São Paulo, 05403, Brazil

Recruiting
9,083 miles (14,618 km)  awayfrom
Новосибирск, Новосибирская область
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Children's Hospital of Eastern Ontario

401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Recruiting
5,385 miles (8,666 km)  awayfrom
Новосибирск, Новосибирская область
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St-Michael's Hospital

30 Bond St, Toronto, ON M5B 1W8, Canada

Site Contact
Recruiting
5,539 miles (8,914 km)  awayfrom
Новосибирск, Новосибирская область
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Sick Kids Hospital

555 University Ave, Toronto, ON M5G 1X8, Canada

Recruiting
5,539 miles (8,914 km)  awayfrom
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Royal University Hospital

103 Hospital Dr, Saskatoon, SK S7N 0W8, Canada

Recruiting
5,012 miles (8,066 km)  awayfrom
Новосибирск, Новосибирская область
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Shenzhen Children's Hospital

Mintian Rd, Fu Tian C B D, Futian Qu, Shenzhen Shi, Guangdong Sheng, China

Recruiting
2,756 miles (4,435 km)  awayfrom
Новосибирск, Новосибирская область
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Nanfang Hospital Affiliated to Nanfang Medical University

1838 Guangzhou N Ave, Baiyun Qu, Guangzhou Shi, Guangdong Sheng, China

Site Contact
Recruiting
2,695 miles (4,338 km)  awayfrom
Новосибирск, Новосибирская область
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Institute of Hematology, Blood Disease Hospital, PUMC&CAMS

Heping, Tianjin, China

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Recruiting
1,923 miles (3,094 km)  awayfrom
Новосибирск, Новосибирская область
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Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology

China, Hubei Sheng, Wuhan Shi, Jiangan Qu, 三阳路

Site Contact
Recruiting
2,283 miles (3,674 km)  awayfrom
Новосибирск, Новосибирская область
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The Affiliated Hospital of Xuzhou Medical University

Yunlong District, Xuzhou, China

Site Contact
Recruiting
2,178 miles (3,505 km)  awayfrom
Новосибирск, Новосибирская область
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The Blood Center of Shandong Province

Jinan, Shandong, China

Recruiting
2,045 miles (3,292 km)  awayfrom
Новосибирск, Новосибирская область
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Beijing Children's Hospital Affiliated to Capital University of Medical Sciences

Fengtai District, China

Recruiting
1,854 miles (2,983 km)  awayfrom
Новосибирск, Новосибирская область
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Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

321 Zhongshan Rd, Gulou Qu, Nanjing Shi, Jiangsu Sheng, China, 210008

Site Contacts
Recruiting
2,352 miles (3,786 km)  awayfrom
Новосибирск, Новосибирская область
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Shenzhen Second People's Hospital

3002 Sungang W Rd, Futian Qu, Shenzhen Shi, Guangdong Sheng, China

Recruiting
2,756 miles (4,436 km)  awayfrom
Новосибирск, Новосибирская область
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Integral Solutions SD SAS

Cra 7 No. 156-68 Edificio North Point Torre 3 Piso 33, Bogotá, Colombia

Recruiting
8,101 miles (13,037 km)  awayfrom
Новосибирск, Новосибирская область
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Fundación Oftalmológica de Santander FOSCAL

Cl. 157 #23-99, Floridablanca, Santander, Colombia

Recruiting
7,929 miles (12,760 km)  awayfrom
Новосибирск, Новосибирская область
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Fakultní nemocnice Ostrava, Krevní centrum

17. listopadu 833/9, 708 00 Ostrava-Poruba, Czechia

Recruiting
2,652 miles (4,268 km)  awayfrom
Новосибирск, Новосибирская область
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Fakultní nemocnice v Motole

V Úvalu 84, 150 06 Praha 5, Czechia

Recruiting
2,784 miles (4,480 km)  awayfrom
Новосибирск, Новосибирская область
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CHU Côte de Nacre - CRTH

Avenue de la Côte de Nacre, 14000 Caen, France

Recruiting
3,342 miles (5,379 km)  awayfrom
Новосибирск, Новосибирская область
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Hôpital de la Mère et de l'Enfant - CHU de LIMOGES

8 Avenue Dominique Larrey, 87000 Limoges, France

Recruiting
3,441 miles (5,537 km)  awayfrom
Новосибирск, Новосибирская область
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CIC

2 Allée des Artilleurs, 42000 Saint-Étienne, France

Recruiting
3,344 miles (5,381 km)  awayfrom
Новосибирск, Новосибирская область
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Aghia Sofia Children's Hospital

Thivon 1, Athina 115 27, Greece

Recruiting
2,944 miles (4,738 km)  awayfrom
Новосибирск, Новосибирская область
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General Hospital of Thessaloniki "Ippokratio"

Konstantinoupoleos 49, Thessaloniki 546 42, Greece

Site Contact
Recruiting
2,853 miles (4,592 km)  awayfrom
Новосибирск, Новосибирская область
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Heim Pál Gyermekkórház

Budapest, Üllői út 86, 1089 Hungary

Recruiting
2,709 miles (4,360 km)  awayfrom
Новосибирск, Новосибирская область
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Debreceni Egyetem Klinikai Kozpont

Debrecen, Nagyerdei krt. 98, 4032 Hungary

Recruiting
2,609 miles (4,199 km)  awayfrom
Новосибирск, Новосибирская область
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Mohács City Hospital

Mohács, Szepessy tér 7, 7700 Hungary

Recruiting
2,785 miles (4,482 km)  awayfrom
Новосибирск, Новосибирская область
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Azienda Ospedaliera Policlinico Consorziale Di Bari

Piazza Giulio Cesare, 11, 70124 Bari BA, Italy

Recruiting
3,070 miles (4,940 km)  awayfrom
Новосибирск, Новосибирская область
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Policlinico S Orsola Malpighi

Via Giuseppe Massarenti, 9, 40138 Bologna BO, Italy

Recruiting
3,128 miles (5,035 km)  awayfrom
Новосибирск, Новосибирская область
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Ospedale Pugliese -Ciaccio

Viale Papa Pio X, 83, 88100 Catanzaro CZ, Italy

Recruiting
3,183 miles (5,122 km)  awayfrom
Новосибирск, Новосибирская область
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Ospedale di Macerata

Via Santa Lucia, 2, 62100 Macerata MC, Italy

Recruiting
3,102 miles (4,993 km)  awayfrom
Новосибирск, Новосибирская область
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Via della Commenda, 10, 20122 Milano MI, Italy

Recruiting
3,166 miles (5,096 km)  awayfrom
Новосибирск, Новосибирская область
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Azienda Ospedaliera Universitaria Federico II

Via Sergio Pansini, 5, 80131 Napoli NA, Italy

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Recruiting
3,184 miles (5,124 km)  awayfrom
Новосибирск, Новосибирская область
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Azienda Ospedaliera di Padova Clinica Medica II

Via Gustavo Modena, 9, 35128 Padova PD, Italy

Recruiting
3,069 miles (4,938 km)  awayfrom
Новосибирск, Новосибирская область
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AOUP P. Giaccone

Via del Vespro, 129, 90127 Palermo PA, Italy

Recruiting
3,348 miles (5,388 km)  awayfrom
Новосибирск, Новосибирская область
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Azienda Ospedaliera Bianchi Melacrino Morelli

Via Giuseppe Melacrino, 21, 89124 Reggio Calabria RC, Italy

Recruiting
3,257 miles (5,242 km)  awayfrom
Новосибирск, Новосибирская область
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Università degli studi di Roma "La Sapienza"

Viale Regina Elena, 334, 00161 Roma RM, Italy

Recruiting
3,201 miles (5,152 km)  awayfrom
Новосибирск, Новосибирская область
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Ospedale Pediatrico Bambino Gesù

Piazza di Sant'Onofrio, 4, 00165 Roma RM, Italy

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Recruiting
3,204 miles (5,156 km)  awayfrom
Новосибирск, Новосибирская область
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Centro Emofilia e Coagulopatie Rare

73020 Scorrano, Province of Lecce, Italy

Recruiting
3,063 miles (4,929 km)  awayfrom
Новосибирск, Новосибирская область
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Ospedale Molinette

Via Cherasco, 15, 10126 Torino TO, Italy

Recruiting
3,242 miles (5,217 km)  awayfrom
Новосибирск, Новосибирская область
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SBHI Chelyabinsk Regional Children's Clinical Hospital

Chelyabinsk, Chelyabinsk Oblast, Russia

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Recruiting
846 miles (1,361 km)  awayfrom
Новосибирск, Новосибирская область
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SBHI of the Republic of Kareliya Republican Hospital n.a. V.A. Baranov

Petrozavodsk, Republic of Karelia, Russia

Recruiting
1,772 miles (2,852 km)  awayfrom
Новосибирск, Новосибирская область
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State Budget Healthcare Institution of Saint-Petersburg "City polyclinic #37"

St Petersburg, Russia, 191186

Recruiting
1,929 miles (3,104 km)  awayfrom
Новосибирск, Новосибирская область
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Clinics of FSBEI High Education Samara SMU of MoH of Russia

Ulitsa Artsybushevskaya, 171, Samara, Samarskaya oblast', Russia, 443001

Recruiting
1,322 miles (2,127 km)  awayfrom
Новосибирск, Новосибирская область
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Hospital Teresa Herrera-Materno Infantil

As, Xubias de Abaixo, s/n, 15009 A Coruña, Spain

Recruiting
3,899 miles (6,275 km)  awayfrom
Новосибирск, Новосибирская область
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Hospital Universitari Vall d'Hebron (HUVH)

Passeig de la Vall d'Hebron, 119, 08035 Barcelona, Spain

Recruiting
3,615 miles (5,818 km)  awayfrom
Новосибирск, Новосибирская область
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Hospital Hospital Sant Joan de Déu

Hospital Sant Joan de Déu, 08950, Barcelona, Spain

Recruiting
3,619 miles (5,824 km)  awayfrom
Новосибирск, Новосибирская область
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Hospital Universitario Son Espases

Carretera de Valldemossa, 79, 07120 Palma, Illes Balears, Spain

Recruiting
3,685 miles (5,931 km)  awayfrom
Новосибирск, Новосибирская область
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Karolinska Universitetssjukhuset Solna

Karolinska Vägen 22, 171 64 Solna, Sweden

Recruiting
2,349 miles (3,781 km)  awayfrom
Новосибирск, Новосибирская область
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Inselspital Bern

Freiburgstrasse 18, 3010 Bern, Switzerland

Recruiting
3,166 miles (5,095 km)  awayfrom
Новосибирск, Новосибирская область
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Universitätsspital Zürich

Rämistrasse 100, 8091 Zürich, Switzerland

Recruiting
3,106 miles (4,999 km)  awayfrom
Новосибирск, Новосибирская область
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Hampshire Hospitals NHS Foundation Trust, Basingstoke and North Hampshire Hospital

Aldermaston Rd, Basingstoke RG24 9NA, UK

Recruiting
3,276 miles (5,272 km)  awayfrom
Новосибирск, Новосибирская область
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East Kent Hospitals University Foundation Trust, Kent & Canterbury Hospital

Ethelbert Rd, Canterbury CT1 3NG, UK

Recruiting
3,203 miles (5,154 km)  awayfrom
Новосибирск, Новосибирская область
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Great Ormond Street Hospital for Children NHS Trust

Great Ormond Street, Holborn, London WC1N 3JH, UK

Recruiting
3,232 miles (5,202 km)  awayfrom
Новосибирск, Новосибирская область
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Landes Frauen und Kinderklinik Linz (LFKK Linz)

Landes-Kinderklinik, Krankenhausstraße, 4020 Linz, Austria

Completed
2,856 miles (4,596 km)  awayfrom
Новосибирск, Новосибирская область
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Laikon General Hospital

Goudi, Athens 115 27, Greece

Completed
2,944 miles (4,738 km)  awayfrom
Новосибирск, Новосибирская область
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Azienda Ospedaliera Universitaria Vittorio Emanuele, Ferrarotto, S. Bambino

Via Salvatore Citelli, 1, 95124 Catania CT, Italy

Completed
3,309 miles (5,326 km)  awayfrom
Новосибирск, Новосибирская область
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Az. Osp. Univ. Careggi

Largo Piero Palagi, 1, 50139 Firenze FI, Italy

Completed
3,163 miles (5,091 km)  awayfrom
Новосибирск, Новосибирская область
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Rikshospitalet

Sognsvannsveien 20, 0372 Oslo, Norway

Completed
2,567 miles (4,131 km)  awayfrom
Новосибирск, Новосибирская область
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Rikshospitalet, Oslo University Hospital

Sognsvannsveien 20, 0372 Oslo, Norway

Completed
2,567 miles (4,131 km)  awayfrom
Новосибирск, Новосибирская область
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Hospital do Divino Espírito Santo

Av. D. Manuel I, 9500-370 Ponta Delgada, Portugal

Completed
4,772 miles (7,680 km)  awayfrom
Новосибирск, Новосибирская область
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Centro Hospitalar e Universitade de Coimbra

Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal

Completed
4,058 miles (6,531 km)  awayfrom
Новосибирск, Новосибирская область
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Royal Prince Alfred Hospital

50 Missenden Rd, Camperdown NSW 2050, Australia

Terminated/Withdrawn
7,345 miles (11,820 km)  awayfrom
Новосибирск, Новосибирская область
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South Metropolitan Health Service trading as Fiona Stanley Hospital

14 Barry Marshall Parade, Murdoch WA 6150, Australia

Terminated/Withdrawn
6,327 miles (10,182 km)  awayfrom
Новосибирск, Новосибирская область
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Kepler Universitätsklinikum Klinik für Kinder-und Jugendheilkunde

Krankenhausstraße 9, 4020 Linz, Austria

Terminated/Withdrawn
2,855 miles (4,595 km)  awayfrom
Новосибирск, Новосибирская область
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Cliniques Universitaires Saint-Luc

Avenue Hippocrate 10, 1200 Bruxelles, Belgium

Terminated/Withdrawn
3,105 miles (4,997 km)  awayfrom
Новосибирск, Новосибирская область
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Stollery Children's Hospital, University of Alberta

Edmonton, AB T6G 2B7, Canada

Terminated/Withdrawn
4,878 miles (7,850 km)  awayfrom
Новосибирск, Новосибирская область
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The Moncton City Hospital

135 Macbeath Ave, Moncton, NB E1C 6Z8, Canada

Terminated/Withdrawn
5,199 miles (8,367 km)  awayfrom
Новосибирск, Новосибирская область
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Fakultní nemocnice Brno

Jihlavská 340/20, 625 00 Brno-Bohunice-Brno-Starý Lískovec, Czechia

Terminated/Withdrawn
2,736 miles (4,404 km)  awayfrom
Новосибирск, Новосибирская область
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Fakultní nemocnice Ostrava, Oddělení dětské hematologie a hematoonkologie

17. listopadu 1790, 708 00 Ostrava-Poruba, Czechia

Terminated/Withdrawn
2,652 miles (4,268 km)  awayfrom
Новосибирск, Новосибирская область
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Rigshospitalet

Blegdamsvej 9, 2100 København, Denmark

Terminated/Withdrawn
2,641 miles (4,251 km)  awayfrom
Новосибирск, Новосибирская область
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"Hôpital Morvan CHRU de Brest"

2 Avenue Foch, 29200 Brest, France

Terminated/Withdrawn
3,520 miles (5,665 km)  awayfrom
Новосибирск, Новосибирская область
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Centre Hospitalier Générale - CTH

Maternité, Rue Lucien Biset, 73000 Chambéry, France

Terminated/Withdrawn
3,283 miles (5,283 km)  awayfrom
Новосибирск, Новосибирская область
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CTRH - CHU Bocage

21000 Dijon, France

Terminated/Withdrawn
3,236 miles (5,208 km)  awayfrom
Новосибирск, Новосибирская область
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Hôpital André Mignot

177 Rue de Versailles, 78150 Le Chesnay, France

Terminated/Withdrawn
3,273 miles (5,267 km)  awayfrom
Новосибирск, Новосибирская область
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CHRU Hôtel Dieu - CRTH

1 Place Alexis-Ricordeau, 44093 Nantes, France

Terminated/Withdrawn
3,475 miles (5,592 km)  awayfrom
Новосибирск, Новосибирская область
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Hôpital Cochin

27 Rue du Faubourg Saint-Jacques, 75014 Paris, France

Terminated/Withdrawn
3,265 miles (5,255 km)  awayfrom
Новосибирск, Новосибирская область
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CHU de Reims Hôpital Maison Blanche - CRTH

45 Rue Cognacq-Jay, 51092 Reims, France

Terminated/Withdrawn
3,189 miles (5,132 km)  awayfrom
Новосибирск, Новосибирская область
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Centre Régional de Traitement de l'Hémophilie et des Maladies hémorragiques. CHU de Rennes - Hôpital Pontchaillou

2 Rue Henri le Guilloux, 35000 Rennes, France

Terminated/Withdrawn
3,438 miles (5,532 km)  awayfrom
Новосибирск, Новосибирская область
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CHRU Charles Nicolle

37 Boulevard Gambetta, 76000 Rouen, France

Terminated/Withdrawn
3,281 miles (5,281 km)  awayfrom
Новосибирск, Новосибирская область
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CHRU Purpan CRTH - Pavillon Sénac

9, 9 Place Lange, 31300 Toulouse, France

Terminated/Withdrawn
3,537 miles (5,693 km)  awayfrom
Новосибирск, Новосибирская область
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Jósa András County Hospital

Nyíregyháza, Jósa András u., 4400 Hungary

Terminated/Withdrawn
2,591 miles (4,169 km)  awayfrom
Новосибирск, Новосибирская область
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Markusovszky Hospital

Szombathely, Markusovszky Lajos u. 5, 9700 Hungary

Terminated/Withdrawn
2,812 miles (4,526 km)  awayfrom
Новосибирск, Новосибирская область
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Policlinico Universitario Gemelli

Via della Pineta Sacchetti, 217, 00168 Roma RM, Italy

Terminated/Withdrawn
3,204 miles (5,156 km)  awayfrom
Новосибирск, Новосибирская область
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Szpital Uniwersytecki nr 1 im. dr Andrzeja Jurasza

Marii Skłodowskiej Curie 9, 85-094 Bydgoszcz, Poland

Terminated/Withdrawn
2,537 miles (4,083 km)  awayfrom
Новосибирск, Новосибирская область
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Samodzielny Publiczny Szpital Kliniczny nr 1

Gdańsk, Poland

Terminated/Withdrawn
2,474 miles (3,982 km)  awayfrom
Новосибирск, Новосибирская область
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Samodzielny Publiczny Dzieciecy Szpital Kliniczny

Żwirki i Wigury 63A, 02-091 Warszawa, Poland

Terminated/Withdrawn
2,462 miles (3,961 km)  awayfrom
Новосибирск, Новосибирская область
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Uniwersytecki Szpital Kliniczny we Wrocławiu

Borowska 213, 50-556 Wrocław, Poland

Terminated/Withdrawn
2,647 miles (4,260 km)  awayfrom
Новосибирск, Новосибирская область
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Centro Hospitalar Lisboa Norte Hospital de Sta. Maria

Av. Prof. Egas Moniz MB, 1649-028 Lisboa, Portugal

Terminated/Withdrawn
4,160 miles (6,695 km)  awayfrom
Новосибирск, Новосибирская область
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Centro Hospitalar de São João, E.P.E.

Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

Terminated/Withdrawn
4,015 miles (6,462 km)  awayfrom
Новосибирск, Новосибирская область
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Federal State Budget Institution "Hematology Research Center" of Ministry of Healthcare of Russian Federation

Moscow, Russia, 125167

Terminated/Withdrawn
1,748 miles (2,813 km)  awayfrom
Новосибирск, Новосибирская область
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University Medical Centre Ljubljana

Zaloška cesta 7, 1000 Ljubljana, Slovenia

Terminated/Withdrawn
2,941 miles (4,733 km)  awayfrom
Новосибирск, Новосибирская область
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Sahlgrenska University Hospital

Blå stråket 5, 413 45 Göteborg, Sweden

Terminated/Withdrawn
2,596 miles (4,178 km)  awayfrom
Новосибирск, Новосибирская область
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Kliniska studier i Sverige - Forum Söder

Skånes universitetssjukhus, Akutgatan 8, 221 85 Lund, Sweden

Terminated/Withdrawn
2,619 miles (4,215 km)  awayfrom
Новосибирск, Новосибирская область
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Universitätsspital Basel

Universitätsspital CH, Petersgraben 4, 4031 Basel, Switzerland

Terminated/Withdrawn
3,134 miles (5,043 km)  awayfrom
Новосибирск, Новосибирская область
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Centre Hospitalier Universitaire Vaudois

Rue du Bugnon 46, 1011 Lausanne, Switzerland

Terminated/Withdrawn
3,213 miles (5,171 km)  awayfrom
Новосибирск, Новосибирская область
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Luzerner Kantonsspital

Spitalstrasse, 6004 Luzern, Switzerland

Terminated/Withdrawn
3,129 miles (5,036 km)  awayfrom
Новосибирск, Новосибирская область
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Kantonsspital St. Gallen

Rorschacher Str. 95, 9001 St. Gallen, Switzerland

Terminated/Withdrawn
3,073 miles (4,946 km)  awayfrom
Новосибирск, Новосибирская область
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FMH Kinder und Jugendmedizin, im Wabern-Zentrum

Wabern bei Bern, 3084 Köniz, Switzerland

Terminated/Withdrawn
3,166 miles (5,095 km)  awayfrom
Новосибирск, Новосибирская область
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Kinderspital Zürich

Steinwiesstrasse 75, 8032 Zürich, Switzerland

Terminated/Withdrawn
3,106 miles (4,999 km)  awayfrom
Новосибирск, Новосибирская область
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Cambridge University Hospital NHS Foundation Trust, Addenbrooke's Hospital

Hills Rd, Cambridge CB2 0QQ, UK

Terminated/Withdrawn
3,196 miles (5,143 km)  awayfrom
Новосибирск, Новосибирская область
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UMHAP Sveti Georgï EAD

Plovdiv, Bulgaria

Terminated/Withdrawn
2,715 miles (4,369 km)  awayfrom
Новосибирск, Новосибирская область
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The Affiliated Hospital of Medical College, Qingdao University

16 Jiangsu Rd, Shinan Qu, Qingdao Shi, Shandong Sheng, China

Terminated/Withdrawn
2,193 miles (3,530 km)  awayfrom
Новосибирск, Новосибирская область
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CHRU Pellegrin

33076 Bordeaux, France

Terminated/Withdrawn
3,553 miles (5,717 km)  awayfrom
Новосибирск, Новосибирская область
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View all (112)
Trial Protocol ID: 061001
Back to Trial Summary