ADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD)

IDENTIFIERS
Trial Protocol: 061001
Clinicaltrials.gov: NCT02078427
PURPOSE

The purpose of the study is to document the natural history of hemophilia A disease and long-term outcomes in terms of effectiveness, safety and quality of life in participants receiving Antihemophilic Factor (Recombinant) - Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) - Pegylated (rAHF-PEG) in routine clinical practice

Recruiting
AU
AT
BE
20+
BR
BG
CA
CN
CO
CZ
DK
FR
GR
HU
IT
NO
PL
PT
RU
SI
ES
SE
CH
GB

Trial at a glance

What medical condition is being studied?   Hemophilia A
What is the trial testing?   ADVATE, ADYNOVI
How many participants are being enrolled?   1130
When is the trial being conducted?    - 
How long is participation in the trial?   a. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) alone b. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) alone with a minimum follow up time of 4 years c. Up to approximately 12 years for currently enrolled subjects treated with rAHF-PFM and subsequently switched to rAHF-PEG (i.e. up to approx. 8 years on rAHF-PFM and at least 4 years on rAHF-PEG)

Key requirements

Sex   
All
Age   
All
Accepts Healthy Volunteers?   
No

Trial Details / Participation Requirements

CLICK TO EXPANDCLICK TO COLLAPSE
Trial Type:   Observational
Trial Arms/Groups or Cohorts:   
rAHF-PFM: Participants treated with rAHF-PFM alone
rAHF-PEG: Participants treated with rAHF-PEG alone
rAHF-PFM then rAHF-PEG: Participants treated with rAHF-PFM and subsequently switched to rAHF-PEG
Intervention:   ADVATE, ADYNOVI
Primary Outcome Measure(s):
Joint Health Outcomes - Assessed by Physical Exam Using Only the Pain, Bleeding, and Physical Exam Parameters of the Gilbert Scale [Time Frame: Up to approximately 12 years]
Secondary Outcome Measure(s):   
Annualized Bleed Rate, All Joints [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized Bleed Rate, All Bleeds [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized bleed rate, pre-existing target joints at baseline [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of New Target Joints [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health by X-ray by Pettersson scale [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit.]
Status of Joint Health by Magnetic Resonance Imaging (MRI) Scoring System- Using The Lund Scoring System (LSS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health using the Hemophilia Joint Health Score (HJHS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for prophylaxis therapy [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Compliance with the dosing prescribed and its relationship with effectiveness [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Global effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG units required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG infusions required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of target joint intervention, including surgery, radiosynovectomy, and chemosynovectomy [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of pseudo tumor development [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: HAL questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-12v2 questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D questionnaire - for adult patients [Time Frame: Enrollment visit;Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: PedHAL questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-10 questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D (14 and up) questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Chronic pain associated with hemophilia, as measured over a period of 4 weeks on an annual basis, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Acute pain associated with hemophilia, as measured with individual bleeding episodes, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Number of days lost from school or work due to bleeding episodes [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 1 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 2 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels Lesser than (<)1%, Lesser Than or Equal to (<=) 2%, and <= 5% without history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% with history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Untreated Patient (PUPs) and Minimally Treated Patients (MTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related non-serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of inhibitors after switching to rAHF-PEG [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Entry Criteria:
Inclusion Criteria: - Participant has hemophilia A {FVIII lesser than or equal to (<=)5%} - Participant is prescribed Antihemophilic Factor (Recombinant) - Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) - Pegylated (rAHF-PEG) by the treating physician - Participant or participant's legally authorized representative provides informed consent Exclusion Criteria: - Participant has known hypersensitivity to the active substance or any of the excipients - Participant has known allergic reaction to mouse or hamster proteins - Participant has participated in another clinical study involving an investigational product (IP) or device within 30 days prior to study enrollment or is scheduled to participate in another clinical study involving another FVIII concentrate or device during the course of this study

Trial Locations

Any
Terminated
Completed
Recruiting
Withdrawn
Any
RESULTS
Medizinische Universitaet Wien

Spitalgasse 23, 1090 Wien, Austria

Recruiting
115 miles (185 km)  awayfrom
Czech Republic
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Hemoce - Ce

Av. José Bastos, 3390 - Rodolfo Teófilo, Fortaleza - CE, 60431-086, Brazil

Recruiting
4,886 miles (7,864 km)  awayfrom
Czech Republic
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Hemocentro do Espírito Santo

Av. Mal. Campos, 1468 - Nazareth, Vitória - ES, 29047-105, Brazil

Site Contact
Recruiting
5,912 miles (9,515 km)  awayfrom
Czech Republic
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Hemepar - Pr

Tv. João Prosdócimo, 145 - Alto da XV, Curitiba - PR, 80045-145, Brazil

Recruiting
6,524 miles (10,500 km)  awayfrom
Czech Republic
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Hemorgs - Rs

Av. Bento Gonçalves, 3722 - Partenon, Porto Alegre - RS, 90650-001, Brazil

Recruiting
6,852 miles (11,027 km)  awayfrom
Czech Republic
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Fundação HEMOPA

Tv. Padre Eutíquio, 2109 - Batista Campos, Belém - PA, 66033-000, Brazil

Recruiting
5,154 miles (8,295 km)  awayfrom
Czech Republic
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Hemocentro da UNICAMP

Universidade Estadual de Campinas - R. Carlos Chagas, 480 - Cidade Universitária, Campinas - SP, 13083-878, Brazil

Recruiting
6,298 miles (10,135 km)  awayfrom
Czech Republic
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Hemocentro Ribeirão Preto - SP

Rua Tenente Catão Roxo, 2501 Entrada pela - R. Prof. Hélio Lourenço - Vila Monte Alegre, Ribeirão Preto - SP, 14051-060, Brazil

Recruiting
6,233 miles (10,030 km)  awayfrom
Czech Republic
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Hemorio - Rj

R. Frei Caneca, 8 - Centro, Rio de Janeiro - RJ, 20211-030, Brazil

Recruiting
6,164 miles (9,920 km)  awayfrom
Czech Republic
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Faculdade de Medicina da Universidade de São Paulo

Pacaembu, São Paulo - State of São Paulo, 05403, Brazil

Recruiting
6,325 miles (10,179 km)  awayfrom
Czech Republic
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Children's Hospital of Eastern Ontario

401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Recruiting
3,981 miles (6,407 km)  awayfrom
Czech Republic
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St-Michael's Hospital

30 Bond St, Toronto, ON M5B 1W8, Canada

Site Contact
Recruiting
4,198 miles (6,757 km)  awayfrom
Czech Republic
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Sick Kids Hospital

555 University Ave, Toronto, ON M5G 1X8, Canada

Recruiting
4,199 miles (6,757 km)  awayfrom
Czech Republic
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Royal University Hospital

103 Hospital Dr, Saskatoon, SK S7N 0W8, Canada

Recruiting
4,622 miles (7,438 km)  awayfrom
Czech Republic
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Shenzhen Children's Hospital

Mintian Rd, Fu Tian C B D, Futian Qu, Shenzhen Shi, Guangdong Sheng, China

Recruiting
5,412 miles (8,710 km)  awayfrom
Czech Republic
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Nanfang Hospital Affiliated to Nanfang Medical University

1838 Guangzhou N Ave, Baiyun Qu, Guangzhou Shi, Guangdong Sheng, China

Site Contact
Recruiting
5,348 miles (8,608 km)  awayfrom
Czech Republic
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Institute of Hematology, Blood Disease Hospital, PUMC&CAMS

Heping, Tianjin, China

Site Contact
Recruiting
4,682 miles (7,536 km)  awayfrom
Czech Republic
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Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology

China, Hubei Sheng, Wuhan Shi, Jiangan Qu, 三阳路

Site Contact
Recruiting
5,004 miles (8,054 km)  awayfrom
Czech Republic
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The Affiliated Hospital of Xuzhou Medical University

Yunlong District, Xuzhou, China

Site Contact
Recruiting
4,931 miles (7,936 km)  awayfrom
Czech Republic
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The Blood Center of Shandong Province

Jinan, Shandong, China

Recruiting
4,804 miles (7,731 km)  awayfrom
Czech Republic
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Beijing Children's Hospital Affiliated to Capital University of Medical Sciences

Fengtai District, China

Recruiting
4,613 miles (7,424 km)  awayfrom
Czech Republic
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Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

321 Zhongshan Rd, Gulou Qu, Nanjing Shi, Jiangsu Sheng, China, 210008

Site Contacts
Recruiting
5,104 miles (8,214 km)  awayfrom
Czech Republic
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Shenzhen Second People's Hospital

3002 Sungang W Rd, Futian Qu, Shenzhen Shi, Guangdong Sheng, China

Recruiting
5,413 miles (8,711 km)  awayfrom
Czech Republic
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Integral Solutions SD SAS

Cra 7 No. 156-68 Edificio North Point Torre 3 Piso 33, Bogotá, Colombia

Recruiting
5,940 miles (9,560 km)  awayfrom
Czech Republic
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Fundación Oftalmológica de Santander FOSCAL

Cl. 157 #23-99, Floridablanca, Santander, Colombia

Recruiting
5,777 miles (9,297 km)  awayfrom
Czech Republic
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Fakultní nemocnice Ostrava, Krevní centrum

17. listopadu 833/9, 708 00 Ostrava-Poruba, Czechia

Recruiting
126 miles (203 km)  awayfrom
Czech Republic
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Fakultní nemocnice v Motole

V Úvalu 84, 150 06 Praha 5, Czechia

Recruiting
50 miles (80 km)  awayfrom
Czech Republic
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CHU Côte de Nacre - CRTH

Avenue de la Côte de Nacre, 14000 Caen, France

Recruiting
704 miles (1,134 km)  awayfrom
Czech Republic
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Hôpital de la Mère et de l'Enfant - CHU de LIMOGES

8 Avenue Dominique Larrey, 87000 Limoges, France

Recruiting
707 miles (1,138 km)  awayfrom
Czech Republic
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CIC

2 Allée des Artilleurs, 42000 Saint-Étienne, France

Recruiting
589 miles (948 km)  awayfrom
Czech Republic
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Aghia Sofia Children's Hospital

Thivon 1, Athina 115 27, Greece

Recruiting
913 miles (1,470 km)  awayfrom
Czech Republic
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General Hospital of Thessaloniki "Ippokratio"

Konstantinoupoleos 49, Thessaloniki 546 42, Greece

Site Contact
Recruiting
731 miles (1,177 km)  awayfrom
Czech Republic
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Heim Pál Gyermekkórház

Budapest, Üllői út 86, 1089 Hungary

Recruiting
232 miles (373 km)  awayfrom
Czech Republic
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Debreceni Egyetem Klinikai Kozpont

Debrecen, Nagyerdei krt. 98, 4032 Hungary

Recruiting
324 miles (522 km)  awayfrom
Czech Republic
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Mohács City Hospital

Mohács, Szepessy tér 7, 7700 Hungary

Recruiting
302 miles (485 km)  awayfrom
Czech Republic
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Azienda Ospedaliera Policlinico Consorziale Di Bari

Piazza Giulio Cesare, 11, 70124 Bari BA, Italy

Recruiting
601 miles (967 km)  awayfrom
Czech Republic
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Policlinico S Orsola Malpighi

Via Giuseppe Massarenti, 9, 40138 Bologna BO, Italy

Recruiting
408 miles (657 km)  awayfrom
Czech Republic
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Ospedale Pugliese -Ciaccio

Viale Papa Pio X, 83, 88100 Catanzaro CZ, Italy

Recruiting
750 miles (1,207 km)  awayfrom
Czech Republic
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Ospedale di Macerata

Via Santa Lucia, 2, 62100 Macerata MC, Italy

Recruiting
454 miles (731 km)  awayfrom
Czech Republic
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Via della Commenda, 10, 20122 Milano MI, Italy

Recruiting
411 miles (662 km)  awayfrom
Czech Republic
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Azienda Ospedaliera Universitaria Federico II

Via Sergio Pansini, 5, 80131 Napoli NA, Italy

Site Contact
Recruiting
616 miles (991 km)  awayfrom
Czech Republic
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Azienda Ospedaliera di Padova Clinica Medica II

Via Gustavo Modena, 9, 35128 Padova PD, Italy

Recruiting
340 miles (548 km)  awayfrom
Czech Republic
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AOUP P. Giaccone

Via del Vespro, 129, 90127 Palermo PA, Italy

Recruiting
810 miles (1,304 km)  awayfrom
Czech Republic
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Azienda Ospedaliera Bianchi Melacrino Morelli

Via Giuseppe Melacrino, 21, 89124 Reggio Calabria RC, Italy

Recruiting
804 miles (1,293 km)  awayfrom
Czech Republic
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Università degli studi di Roma "La Sapienza"

Viale Regina Elena, 334, 00161 Roma RM, Italy

Recruiting
558 miles (898 km)  awayfrom
Czech Republic
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Ospedale Pediatrico Bambino Gesù

Piazza di Sant'Onofrio, 4, 00165 Roma RM, Italy

Site contact
Recruiting
559 miles (900 km)  awayfrom
Czech Republic
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Centro Emofilia e Coagulopatie Rare

73020 Scorrano, Province of Lecce, Italy

Recruiting
684 miles (1,100 km)  awayfrom
Czech Republic
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Ospedale Molinette

Via Cherasco, 15, 10126 Torino TO, Italy

Recruiting
483 miles (778 km)  awayfrom
Czech Republic
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SBHI Chelyabinsk Regional Children's Clinical Hospital

Chelyabinsk, Chelyabinsk Oblast, Russia

Site Contact
Recruiting
1,939 miles (3,121 km)  awayfrom
Czech Republic
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SBHI of the Republic of Kareliya Republican Hospital n.a. V.A. Baranov

Petrozavodsk, Republic of Karelia, Russia

Recruiting
1,105 miles (1,778 km)  awayfrom
Czech Republic
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State Budget Healthcare Institution of Saint-Petersburg "City polyclinic #37"

St Petersburg, Russia, 191186

Recruiting
919 miles (1,478 km)  awayfrom
Czech Republic
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Clinics of FSBEI High Education Samara SMU of MoH of Russia

Ulitsa Artsybushevskaya, 171, Samara, Samarskaya oblast', Russia, 443001

Recruiting
1,501 miles (2,415 km)  awayfrom
Czech Republic
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Hospital Teresa Herrera-Materno Infantil

As, Xubias de Abaixo, s/n, 15009 A Coruña, Spain

Recruiting
1,205 miles (1,939 km)  awayfrom
Czech Republic
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Hospital Universitari Vall d'Hebron (HUVH)

Passeig de la Vall d'Hebron, 119, 08035 Barcelona, Spain

Recruiting
856 miles (1,378 km)  awayfrom
Czech Republic
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Hospital Hospital Sant Joan de Déu

Hospital Sant Joan de Déu, 08950, Barcelona, Spain

Recruiting
860 miles (1,384 km)  awayfrom
Czech Republic
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Hospital Universitario Son Espases

Carretera de Valldemossa, 79, 07120 Palma, Illes Balears, Spain

Recruiting
935 miles (1,505 km)  awayfrom
Czech Republic
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Karolinska Universitetssjukhuset Solna

Karolinska Vägen 22, 171 64 Solna, Sweden

Recruiting
672 miles (1,082 km)  awayfrom
Czech Republic
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Inselspital Bern

Freiburgstrasse 18, 3010 Bern, Switzerland

Recruiting
411 miles (662 km)  awayfrom
Czech Republic
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Universitätsspital Zürich

Rämistrasse 100, 8091 Zürich, Switzerland

Recruiting
351 miles (564 km)  awayfrom
Czech Republic
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Hampshire Hospitals NHS Foundation Trust, Basingstoke and North Hampshire Hospital

Aldermaston Rd, Basingstoke RG24 9NA, UK

Recruiting
729 miles (1,173 km)  awayfrom
Czech Republic
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East Kent Hospitals University Foundation Trust, Kent & Canterbury Hospital

Ethelbert Rd, Canterbury CT1 3NG, UK

Recruiting
634 miles (1,020 km)  awayfrom
Czech Republic
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Great Ormond Street Hospital for Children NHS Trust

Great Ormond Street, Holborn, London WC1N 3JH, UK

Recruiting
687 miles (1,106 km)  awayfrom
Czech Republic
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Landes Frauen und Kinderklinik Linz (LFKK Linz)

Landes-Kinderklinik, Krankenhausstraße, 4020 Linz, Austria

Completed
110 miles (177 km)  awayfrom
Czech Republic
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Laikon General Hospital

Goudi, Athens 115 27, Greece

Completed
913 miles (1,469 km)  awayfrom
Czech Republic
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Azienda Ospedaliera Universitaria Vittorio Emanuele, Ferrarotto, S. Bambino

Via Salvatore Citelli, 1, 95124 Catania CT, Italy

Completed
845 miles (1,361 km)  awayfrom
Czech Republic
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Az. Osp. Univ. Careggi

Largo Piero Palagi, 1, 50139 Firenze FI, Italy

Completed
453 miles (730 km)  awayfrom
Czech Republic
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Rikshospitalet

Sognsvannsveien 20, 0372 Oslo, Norway

Completed
728 miles (1,172 km)  awayfrom
Czech Republic
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Rikshospitalet, Oslo University Hospital

Sognsvannsveien 20, 0372 Oslo, Norway

Completed
728 miles (1,172 km)  awayfrom
Czech Republic
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Hospital do Divino Espírito Santo

Av. D. Manuel I, 9500-370 Ponta Delgada, Portugal

Completed
2,175 miles (3,501 km)  awayfrom
Czech Republic
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Centro Hospitalar e Universitade de Coimbra

Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal

Completed
1,326 miles (2,134 km)  awayfrom
Czech Republic
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Royal Prince Alfred Hospital

50 Missenden Rd, Camperdown NSW 2050, Australia

Terminated/Withdrawn
9,958 miles (16,026 km)  awayfrom
Czech Republic
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South Metropolitan Health Service trading as Fiona Stanley Hospital

14 Barry Marshall Parade, Murdoch WA 6150, Australia

Terminated/Withdrawn
8,314 miles (13,380 km)  awayfrom
Czech Republic
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Kepler Universitätsklinikum Klinik für Kinder-und Jugendheilkunde

Krankenhausstraße 9, 4020 Linz, Austria

Terminated/Withdrawn
110 miles (177 km)  awayfrom
Czech Republic
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Cliniques Universitaires Saint-Luc

Avenue Hippocrate 10, 1200 Bruxelles, Belgium

Terminated/Withdrawn
486 miles (782 km)  awayfrom
Czech Republic
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Stollery Children's Hospital, University of Alberta

Edmonton, AB T6G 2B7, Canada

Terminated/Withdrawn
4,707 miles (7,575 km)  awayfrom
Czech Republic
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The Moncton City Hospital

135 Macbeath Ave, Moncton, NB E1C 6Z8, Canada

Terminated/Withdrawn
3,537 miles (5,693 km)  awayfrom
Czech Republic
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Fakultní nemocnice Brno

Jihlavská 340/20, 625 00 Brno-Bohunice-Brno-Starý Lískovec, Czechia

Terminated/Withdrawn
68 miles (109 km)  awayfrom
Czech Republic
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Fakultní nemocnice Ostrava, Oddělení dětské hematologie a hematoonkologie

17. listopadu 1790, 708 00 Ostrava-Poruba, Czechia

Terminated/Withdrawn
126 miles (203 km)  awayfrom
Czech Republic
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Rigshospitalet

Blegdamsvej 9, 2100 København, Denmark

Terminated/Withdrawn
427 miles (688 km)  awayfrom
Czech Republic
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"Hôpital Morvan CHRU de Brest"

2 Avenue Foch, 29200 Brest, France

Terminated/Withdrawn
900 miles (1,448 km)  awayfrom
Czech Republic
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Centre Hospitalier Générale - CTH

Maternité, Rue Lucien Biset, 73000 Chambéry, France

Terminated/Withdrawn
525 miles (844 km)  awayfrom
Czech Republic
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CTRH - CHU Bocage

21000 Dijon, France

Terminated/Withdrawn
499 miles (804 km)  awayfrom
Czech Republic
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Hôpital André Mignot

177 Rue de Versailles, 78150 Le Chesnay, France

Terminated/Withdrawn
598 miles (962 km)  awayfrom
Czech Republic
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CHRU Hôtel Dieu - CRTH

1 Place Alexis-Ricordeau, 44093 Nantes, France

Terminated/Withdrawn
791 miles (1,274 km)  awayfrom
Czech Republic
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Hôpital Cochin

27 Rue du Faubourg Saint-Jacques, 75014 Paris, France

Terminated/Withdrawn
588 miles (947 km)  awayfrom
Czech Republic
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CHU de Reims Hôpital Maison Blanche - CRTH

45 Rue Cognacq-Jay, 51092 Reims, France

Terminated/Withdrawn
509 miles (819 km)  awayfrom
Czech Republic
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Centre Régional de Traitement de l'Hémophilie et des Maladies hémorragiques. CHU de Rennes - Hôpital Pontchaillou

2 Rue Henri le Guilloux, 35000 Rennes, France

Terminated/Withdrawn
779 miles (1,254 km)  awayfrom
Czech Republic
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CHRU Charles Nicolle

37 Boulevard Gambetta, 76000 Rouen, France

Terminated/Withdrawn
637 miles (1,025 km)  awayfrom
Czech Republic
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CHRU Purpan CRTH - Pavillon Sénac

9, 9 Place Lange, 31300 Toulouse, France

Terminated/Withdrawn
782 miles (1,259 km)  awayfrom
Czech Republic
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Jósa András County Hospital

Nyíregyháza, Jósa András u., 4400 Hungary

Terminated/Withdrawn
315 miles (507 km)  awayfrom
Czech Republic
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Markusovszky Hospital

Szombathely, Markusovszky Lajos u. 5, 9700 Hungary

Terminated/Withdrawn
183 miles (294 km)  awayfrom
Czech Republic
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Policlinico Universitario Gemelli

Via della Pineta Sacchetti, 217, 00168 Roma RM, Italy

Terminated/Withdrawn
557 miles (897 km)  awayfrom
Czech Republic
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Szpital Uniwersytecki nr 1 im. dr Andrzeja Jurasza

Marii Skłodowskiej Curie 9, 85-094 Bydgoszcz, Poland

Terminated/Withdrawn
261 miles (420 km)  awayfrom
Czech Republic
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Samodzielny Publiczny Szpital Kliniczny nr 1

Gdańsk, Poland

Terminated/Withdrawn
348 miles (560 km)  awayfrom
Czech Republic
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Samodzielny Publiczny Dzieciecy Szpital Kliniczny

Żwirki i Wigury 63A, 02-091 Warszawa, Poland

Terminated/Withdrawn
299 miles (481 km)  awayfrom
Czech Republic
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Uniwersytecki Szpital Kliniczny we Wrocławiu

Borowska 213, 50-556 Wrocław, Poland

Terminated/Withdrawn
118 miles (191 km)  awayfrom
Czech Republic
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Centro Hospitalar Lisboa Norte Hospital de Sta. Maria

Av. Prof. Egas Moniz MB, 1649-028 Lisboa, Portugal

Terminated/Withdrawn
1,421 miles (2,287 km)  awayfrom
Czech Republic
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Centro Hospitalar de São João, E.P.E.

Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

Terminated/Withdrawn
1,294 miles (2,083 km)  awayfrom
Czech Republic
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Federal State Budget Institution "Hematology Research Center" of Ministry of Healthcare of Russian Federation

Moscow, Russia, 125167

Terminated/Withdrawn
1,012 miles (1,629 km)  awayfrom
Czech Republic
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University Medical Centre Ljubljana

Zaloška cesta 7, 1000 Ljubljana, Slovenia

Terminated/Withdrawn
258 miles (415 km)  awayfrom
Czech Republic
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Sahlgrenska University Hospital

Blå stråket 5, 413 45 Göteborg, Sweden

Terminated/Withdrawn
565 miles (910 km)  awayfrom
Czech Republic
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Kliniska studier i Sverige - Forum Söder

Skånes universitetssjukhus, Akutgatan 8, 221 85 Lund, Sweden

Terminated/Withdrawn
422 miles (679 km)  awayfrom
Czech Republic
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Universitätsspital Basel

Universitätsspital CH, Petersgraben 4, 4031 Basel, Switzerland

Terminated/Withdrawn
384 miles (619 km)  awayfrom
Czech Republic
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Centre Hospitalier Universitaire Vaudois

Rue du Bugnon 46, 1011 Lausanne, Switzerland

Terminated/Withdrawn
458 miles (737 km)  awayfrom
Czech Republic
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Luzerner Kantonsspital

Spitalstrasse, 6004 Luzern, Switzerland

Terminated/Withdrawn
372 miles (599 km)  awayfrom
Czech Republic
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Kantonsspital St. Gallen

Rorschacher Str. 95, 9001 St. Gallen, Switzerland

Terminated/Withdrawn
315 miles (507 km)  awayfrom
Czech Republic
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FMH Kinder und Jugendmedizin, im Wabern-Zentrum

Wabern bei Bern, 3084 Köniz, Switzerland

Terminated/Withdrawn
411 miles (661 km)  awayfrom
Czech Republic
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Kinderspital Zürich

Steinwiesstrasse 75, 8032 Zürich, Switzerland

Terminated/Withdrawn
350 miles (564 km)  awayfrom
Czech Republic
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Cambridge University Hospital NHS Foundation Trust, Addenbrooke's Hospital

Hills Rd, Cambridge CB2 0QQ, UK

Terminated/Withdrawn
681 miles (1,096 km)  awayfrom
Czech Republic
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UMHAP Sveti Georgï EAD

Plovdiv, Bulgaria

Terminated/Withdrawn
692 miles (1,114 km)  awayfrom
Czech Republic
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The Affiliated Hospital of Medical College, Qingdao University

16 Jiangsu Rd, Shinan Qu, Qingdao Shi, Shandong Sheng, China

Terminated/Withdrawn
4,953 miles (7,971 km)  awayfrom
Czech Republic
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CHRU Pellegrin

33076 Bordeaux, France

Terminated/Withdrawn
819 miles (1,317 km)  awayfrom
Czech Republic
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View all (112)
Trial Protocol ID: 061001
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