ADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD)

IDENTIFIERS
Trial Protocol: 061001
Clinicaltrials.gov: NCT02078427
PURPOSE

The purpose of the study is to document the natural history of hemophilia A disease and long-term outcomes in terms of effectiveness, safety and quality of life in participants receiving Antihemophilic Factor (Recombinant) - Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) - Pegylated (rAHF-PEG) in routine clinical practice

Recruiting
AU
AT
BE
20+
BR
BG
CA
CN
CO
CZ
DK
FR
GR
HU
IT
NO
PL
PT
RU
SI
ES
SE
CH
GB

Trial at a glance

What medical condition is being studied?   Hemophilia A
What is the trial testing?   ADVATE, ADYNOVI
How many participants are being enrolled?   1130
When is the trial being conducted?    - 
How long is participation in the trial?   a. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) alone b. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) alone with a minimum follow up time of 4 years c. Up to approximately 12 years for currently enrolled subjects treated with rAHF-PFM and subsequently switched to rAHF-PEG (i.e. up to approx. 8 years on rAHF-PFM and at least 4 years on rAHF-PEG)

Key requirements

Sex   
All
Age   
All
Accepts Healthy Volunteers?   
No

Trial Details / Participation Requirements

CLICK TO EXPANDCLICK TO COLLAPSE
Trial Type:   Observational
Trial Arms/Groups or Cohorts:   
rAHF-PFM: Participants treated with rAHF-PFM alone
rAHF-PEG: Participants treated with rAHF-PEG alone
rAHF-PFM then rAHF-PEG: Participants treated with rAHF-PFM and subsequently switched to rAHF-PEG
Intervention:   ADVATE, ADYNOVI
Primary Outcome Measure(s):
Joint Health Outcomes - Assessed by Physical Exam Using Only the Pain, Bleeding, and Physical Exam Parameters of the Gilbert Scale [Time Frame: Up to approximately 12 years]
Secondary Outcome Measure(s):   
Annualized Bleed Rate, All Joints [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized Bleed Rate, All Bleeds [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized bleed rate, pre-existing target joints at baseline [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of New Target Joints [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health by X-ray by Pettersson scale [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit.]
Status of Joint Health by Magnetic Resonance Imaging (MRI) Scoring System- Using The Lund Scoring System (LSS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health using the Hemophilia Joint Health Score (HJHS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for prophylaxis therapy [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Compliance with the dosing prescribed and its relationship with effectiveness [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Global effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG units required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG infusions required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of target joint intervention, including surgery, radiosynovectomy, and chemosynovectomy [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of pseudo tumor development [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: HAL questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-12v2 questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D questionnaire - for adult patients [Time Frame: Enrollment visit;Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: PedHAL questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-10 questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D (14 and up) questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Chronic pain associated with hemophilia, as measured over a period of 4 weeks on an annual basis, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Acute pain associated with hemophilia, as measured with individual bleeding episodes, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Number of days lost from school or work due to bleeding episodes [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 1 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 2 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels Lesser than (<)1%, Lesser Than or Equal to (<=) 2%, and <= 5% without history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% with history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Untreated Patient (PUPs) and Minimally Treated Patients (MTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related non-serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of inhibitors after switching to rAHF-PEG [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Entry Criteria:
Inclusion Criteria: - Participant has hemophilia A {FVIII lesser than or equal to (<=)5%} - Participant is prescribed Antihemophilic Factor (Recombinant) - Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) - Pegylated (rAHF-PEG) by the treating physician - Participant or participant's legally authorized representative provides informed consent Exclusion Criteria: - Participant has known hypersensitivity to the active substance or any of the excipients - Participant has known allergic reaction to mouse or hamster proteins - Participant has participated in another clinical study involving an investigational product (IP) or device within 30 days prior to study enrollment or is scheduled to participate in another clinical study involving another FVIII concentrate or device during the course of this study

Trial Locations

Any
Terminated
Completed
Recruiting
Withdrawn
Any
RESULTS
Medizinische Universitaet Wien

Spitalgasse 23, 1090 Wien, Austria

Recruiting
4,032 miles (6,488 km)  awayfrom
Boston, Massachusetts
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Hemoce - Ce

Av. José Bastos, 3390 - Rodolfo Teófilo, Fortaleza - CE, 60431-086, Brazil

Recruiting
3,780 miles (6,083 km)  awayfrom
Boston, Massachusetts
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Hemocentro do Espírito Santo

Av. Mal. Campos, 1468 - Nazareth, Vitória - ES, 29047-105, Brazil

Site Contact
Recruiting
4,752 miles (7,648 km)  awayfrom
Boston, Massachusetts
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Hemepar - Pr

Tv. João Prosdócimo, 145 - Alto da XV, Curitiba - PR, 80045-145, Brazil

Recruiting
4,885 miles (7,862 km)  awayfrom
Boston, Massachusetts
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Hemorgs - Rs

Av. Bento Gonçalves, 3722 - Partenon, Porto Alegre - RS, 90650-001, Brazil

Recruiting
5,161 miles (8,306 km)  awayfrom
Boston, Massachusetts
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Fundação HEMOPA

Tv. Padre Eutíquio, 2109 - Batista Campos, Belém - PA, 66033-000, Brazil

Recruiting
3,339 miles (5,373 km)  awayfrom
Boston, Massachusetts
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Hemocentro da UNICAMP

Universidade Estadual de Campinas - R. Carlos Chagas, 480 - Cidade Universitária, Campinas - SP, 13083-878, Brazil

Recruiting
4,757 miles (7,656 km)  awayfrom
Boston, Massachusetts
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Hemocentro Ribeirão Preto - SP

Rua Tenente Catão Roxo, 2501 Entrada pela - R. Prof. Hélio Lourenço - Vila Monte Alegre, Ribeirão Preto - SP, 14051-060, Brazil

Recruiting
4,632 miles (7,454 km)  awayfrom
Boston, Massachusetts
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Hemorio - Rj

R. Frei Caneca, 8 - Centro, Rio de Janeiro - RJ, 20211-030, Brazil

Recruiting
4,847 miles (7,801 km)  awayfrom
Boston, Massachusetts
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Faculdade de Medicina da Universidade de São Paulo

Pacaembu, São Paulo - State of São Paulo, 05403, Brazil

Recruiting
4,813 miles (7,745 km)  awayfrom
Boston, Massachusetts
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Children's Hospital of Eastern Ontario

401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Recruiting
310 miles (500 km)  awayfrom
Boston, Massachusetts
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St-Michael's Hospital

30 Bond St, Toronto, ON M5B 1W8, Canada

Site Contact
Recruiting
429 miles (691 km)  awayfrom
Boston, Massachusetts
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Sick Kids Hospital

555 University Ave, Toronto, ON M5G 1X8, Canada

Recruiting
430 miles (692 km)  awayfrom
Boston, Massachusetts
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Royal University Hospital

103 Hospital Dr, Saskatoon, SK S7N 0W8, Canada

Recruiting
1,778 miles (2,862 km)  awayfrom
Boston, Massachusetts
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Shenzhen Children's Hospital

Mintian Rd, Fu Tian C B D, Futian Qu, Shenzhen Shi, Guangdong Sheng, China

Recruiting
7,940 miles (12,778 km)  awayfrom
Boston, Massachusetts
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Nanfang Hospital Affiliated to Nanfang Medical University

1838 Guangzhou N Ave, Baiyun Qu, Guangzhou Shi, Guangdong Sheng, China

Site Contact
Recruiting
7,899 miles (12,712 km)  awayfrom
Boston, Massachusetts
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Institute of Hematology, Blood Disease Hospital, PUMC&CAMS

Heping, Tianjin, China

Site Contact
Recruiting
6,783 miles (10,916 km)  awayfrom
Boston, Massachusetts
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Tongji Hospital, Tongji Medical College of Huazhong University of Science & Technology

China, Hubei Sheng, Wuhan Shi, Jiangan Qu, 三阳路

Site Contact
Recruiting
7,384 miles (11,883 km)  awayfrom
Boston, Massachusetts
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The Affiliated Hospital of Xuzhou Medical University

Yunlong District, Xuzhou, China

Site Contact
Recruiting
7,116 miles (11,452 km)  awayfrom
Boston, Massachusetts
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The Blood Center of Shandong Province

Jinan, Shandong, China

Recruiting
6,953 miles (11,190 km)  awayfrom
Boston, Massachusetts
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Beijing Children's Hospital Affiliated to Capital University of Medical Sciences

Fengtai District, China

Recruiting
6,736 miles (10,841 km)  awayfrom
Boston, Massachusetts
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Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

321 Zhongshan Rd, Gulou Qu, Nanjing Shi, Jiangsu Sheng, China, 210008

Site Contacts
Recruiting
7,257 miles (11,679 km)  awayfrom
Boston, Massachusetts
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Shenzhen Second People's Hospital

3002 Sungang W Rd, Futian Qu, Shenzhen Shi, Guangdong Sheng, China

Recruiting
7,939 miles (12,777 km)  awayfrom
Boston, Massachusetts
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Integral Solutions SD SAS

Cra 7 No. 156-68 Edificio North Point Torre 3 Piso 33, Bogotá, Colombia

Recruiting
2,606 miles (4,194 km)  awayfrom
Boston, Massachusetts
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Fundación Oftalmológica de Santander FOSCAL

Cl. 157 #23-99, Floridablanca, Santander, Colombia

Recruiting
2,441 miles (3,929 km)  awayfrom
Boston, Massachusetts
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Fakultní nemocnice Ostrava, Krevní centrum

17. listopadu 833/9, 708 00 Ostrava-Poruba, Czechia

Recruiting
4,047 miles (6,513 km)  awayfrom
Boston, Massachusetts
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Fakultní nemocnice v Motole

V Úvalu 84, 150 06 Praha 5, Czechia

Recruiting
3,890 miles (6,261 km)  awayfrom
Boston, Massachusetts
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CHU Côte de Nacre - CRTH

Avenue de la Côte de Nacre, 14000 Caen, France

Recruiting
3,314 miles (5,333 km)  awayfrom
Boston, Massachusetts
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Hôpital de la Mère et de l'Enfant - CHU de LIMOGES

8 Avenue Dominique Larrey, 87000 Limoges, France

Recruiting
3,470 miles (5,585 km)  awayfrom
Boston, Massachusetts
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CIC

2 Allée des Artilleurs, 42000 Saint-Étienne, France

Recruiting
3,618 miles (5,823 km)  awayfrom
Boston, Massachusetts
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Aghia Sofia Children's Hospital

Thivon 1, Athina 115 27, Greece

Recruiting
4,736 miles (7,622 km)  awayfrom
Boston, Massachusetts
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General Hospital of Thessaloniki "Ippokratio"

Konstantinoupoleos 49, Thessaloniki 546 42, Greece

Site Contact
Recruiting
4,592 miles (7,391 km)  awayfrom
Boston, Massachusetts
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Heim Pál Gyermekkórház

Budapest, Üllői út 86, 1089 Hungary

Recruiting
4,167 miles (6,706 km)  awayfrom
Boston, Massachusetts
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Debreceni Egyetem Klinikai Kozpont

Debrecen, Nagyerdei krt. 98, 4032 Hungary

Recruiting
4,264 miles (6,862 km)  awayfrom
Boston, Massachusetts
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Mohács City Hospital

Mohács, Szepessy tér 7, 7700 Hungary

Recruiting
4,205 miles (6,767 km)  awayfrom
Boston, Massachusetts
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Azienda Ospedaliera Policlinico Consorziale Di Bari

Piazza Giulio Cesare, 11, 70124 Bari BA, Italy

Recruiting
4,311 miles (6,939 km)  awayfrom
Boston, Massachusetts
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Policlinico S Orsola Malpighi

Via Giuseppe Massarenti, 9, 40138 Bologna BO, Italy

Recruiting
3,952 miles (6,360 km)  awayfrom
Boston, Massachusetts
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Ospedale Pugliese -Ciaccio

Viale Papa Pio X, 83, 88100 Catanzaro CZ, Italy

Recruiting
4,384 miles (7,055 km)  awayfrom
Boston, Massachusetts
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Ospedale di Macerata

Via Santa Lucia, 2, 62100 Macerata MC, Italy

Recruiting
4,084 miles (6,572 km)  awayfrom
Boston, Massachusetts
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Via della Commenda, 10, 20122 Milano MI, Italy

Recruiting
3,827 miles (6,159 km)  awayfrom
Boston, Massachusetts
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Azienda Ospedaliera Universitaria Federico II

Via Sergio Pansini, 5, 80131 Napoli NA, Italy

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Recruiting
4,205 miles (6,768 km)  awayfrom
Boston, Massachusetts
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Azienda Ospedaliera di Padova Clinica Medica II

Via Gustavo Modena, 9, 35128 Padova PD, Italy

Recruiting
3,944 miles (6,347 km)  awayfrom
Boston, Massachusetts
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AOUP P. Giaccone

Via del Vespro, 129, 90127 Palermo PA, Italy

Recruiting
4,271 miles (6,873 km)  awayfrom
Boston, Massachusetts
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Azienda Ospedaliera Bianchi Melacrino Morelli

Via Giuseppe Melacrino, 21, 89124 Reggio Calabria RC, Italy

Recruiting
4,374 miles (7,040 km)  awayfrom
Boston, Massachusetts
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Università degli studi di Roma "La Sapienza"

Viale Regina Elena, 334, 00161 Roma RM, Italy

Recruiting
4,092 miles (6,586 km)  awayfrom
Boston, Massachusetts
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Ospedale Pediatrico Bambino Gesù

Piazza di Sant'Onofrio, 4, 00165 Roma RM, Italy

Site contact
Recruiting
4,090 miles (6,583 km)  awayfrom
Boston, Massachusetts
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Centro Emofilia e Coagulopatie Rare

73020 Scorrano, Province of Lecce, Italy

Recruiting
4,413 miles (7,103 km)  awayfrom
Boston, Massachusetts
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Ospedale Molinette

Via Cherasco, 15, 10126 Torino TO, Italy

Recruiting
3,775 miles (6,075 km)  awayfrom
Boston, Massachusetts
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SBHI Chelyabinsk Regional Children's Clinical Hospital

Chelyabinsk, Chelyabinsk Oblast, Russia

Site Contact
Recruiting
5,144 miles (8,279 km)  awayfrom
Boston, Massachusetts
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SBHI of the Republic of Kareliya Republican Hospital n.a. V.A. Baranov

Petrozavodsk, Republic of Karelia, Russia

Recruiting
4,142 miles (6,666 km)  awayfrom
Boston, Massachusetts
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State Budget Healthcare Institution of Saint-Petersburg "City polyclinic #37"

St Petersburg, Russia, 191186

Recruiting
4,099 miles (6,597 km)  awayfrom
Boston, Massachusetts
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Clinics of FSBEI High Education Samara SMU of MoH of Russia

Ulitsa Artsybushevskaya, 171, Samara, Samarskaya oblast', Russia, 443001

Recruiting
4,969 miles (7,997 km)  awayfrom
Boston, Massachusetts
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Hospital Teresa Herrera-Materno Infantil

As, Xubias de Abaixo, s/n, 15009 A Coruña, Spain

Recruiting
3,098 miles (4,985 km)  awayfrom
Boston, Massachusetts
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Hospital Universitari Vall d'Hebron (HUVH)

Passeig de la Vall d'Hebron, 119, 08035 Barcelona, Spain

Recruiting
3,641 miles (5,860 km)  awayfrom
Boston, Massachusetts
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Hospital Hospital Sant Joan de Déu

Hospital Sant Joan de Déu, 08950, Barcelona, Spain

Recruiting
3,641 miles (5,859 km)  awayfrom
Boston, Massachusetts
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Hospital Universitario Son Espases

Carretera de Valldemossa, 79, 07120 Palma, Illes Balears, Spain

Recruiting
3,724 miles (5,992 km)  awayfrom
Boston, Massachusetts
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Karolinska Universitetssjukhuset Solna

Karolinska Vägen 22, 171 64 Solna, Sweden

Recruiting
3,741 miles (6,021 km)  awayfrom
Boston, Massachusetts
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Inselspital Bern

Freiburgstrasse 18, 3010 Bern, Switzerland

Recruiting
3,705 miles (5,963 km)  awayfrom
Boston, Massachusetts
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Universitätsspital Zürich

Rämistrasse 100, 8091 Zürich, Switzerland

Recruiting
3,739 miles (6,018 km)  awayfrom
Boston, Massachusetts
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Hampshire Hospitals NHS Foundation Trust, Basingstoke and North Hampshire Hospital

Aldermaston Rd, Basingstoke RG24 9NA, UK

Recruiting
3,235 miles (5,207 km)  awayfrom
Boston, Massachusetts
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East Kent Hospitals University Foundation Trust, Kent & Canterbury Hospital

Ethelbert Rd, Canterbury CT1 3NG, UK

Recruiting
3,326 miles (5,352 km)  awayfrom
Boston, Massachusetts
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Great Ormond Street Hospital for Children NHS Trust

Great Ormond Street, Holborn, London WC1N 3JH, UK

Recruiting
3,271 miles (5,264 km)  awayfrom
Boston, Massachusetts
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Landes Frauen und Kinderklinik Linz (LFKK Linz)

Landes-Kinderklinik, Krankenhausstraße, 4020 Linz, Austria

Completed
3,947 miles (6,352 km)  awayfrom
Boston, Massachusetts
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Laikon General Hospital

Goudi, Athens 115 27, Greece

Completed
4,736 miles (7,622 km)  awayfrom
Boston, Massachusetts
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Azienda Ospedaliera Universitaria Vittorio Emanuele, Ferrarotto, S. Bambino

Via Salvatore Citelli, 1, 95124 Catania CT, Italy

Completed
4,371 miles (7,035 km)  awayfrom
Boston, Massachusetts
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Az. Osp. Univ. Careggi

Largo Piero Palagi, 1, 50139 Firenze FI, Italy

Completed
3,970 miles (6,390 km)  awayfrom
Boston, Massachusetts
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Rikshospitalet

Sognsvannsveien 20, 0372 Oslo, Norway

Completed
3,489 miles (5,614 km)  awayfrom
Boston, Massachusetts
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Rikshospitalet, Oslo University Hospital

Sognsvannsveien 20, 0372 Oslo, Norway

Completed
3,489 miles (5,614 km)  awayfrom
Boston, Massachusetts
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Hospital do Divino Espírito Santo

Av. D. Manuel I, 9500-370 Ponta Delgada, Portugal

Completed
2,392 miles (3,850 km)  awayfrom
Boston, Massachusetts
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Centro Hospitalar e Universitade de Coimbra

Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal

Completed
3,180 miles (5,118 km)  awayfrom
Boston, Massachusetts
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Royal Prince Alfred Hospital

50 Missenden Rd, Camperdown NSW 2050, Australia

Terminated/Withdrawn
10,093 miles (16,242 km)  awayfrom
Boston, Massachusetts
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South Metropolitan Health Service trading as Fiona Stanley Hospital

14 Barry Marshall Parade, Murdoch WA 6150, Australia

Terminated/Withdrawn
11,631 miles (18,718 km)  awayfrom
Boston, Massachusetts
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Kepler Universitätsklinikum Klinik für Kinder-und Jugendheilkunde

Krankenhausstraße 9, 4020 Linz, Austria

Terminated/Withdrawn
3,947 miles (6,352 km)  awayfrom
Boston, Massachusetts
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Cliniques Universitaires Saint-Luc

Avenue Hippocrate 10, 1200 Bruxelles, Belgium

Terminated/Withdrawn
3,473 miles (5,589 km)  awayfrom
Boston, Massachusetts
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Stollery Children's Hospital, University of Alberta

Edmonton, AB T6G 2B7, Canada

Terminated/Withdrawn
2,074 miles (3,338 km)  awayfrom
Boston, Massachusetts
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The Moncton City Hospital

135 Macbeath Ave, Moncton, NB E1C 6Z8, Canada

Terminated/Withdrawn
403 miles (649 km)  awayfrom
Boston, Massachusetts
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Fakultní nemocnice Brno

Jihlavská 340/20, 625 00 Brno-Bohunice-Brno-Starý Lískovec, Czechia

Terminated/Withdrawn
4,008 miles (6,450 km)  awayfrom
Boston, Massachusetts
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Fakultní nemocnice Ostrava, Oddělení dětské hematologie a hematoonkologie

17. listopadu 1790, 708 00 Ostrava-Poruba, Czechia

Terminated/Withdrawn
4,047 miles (6,513 km)  awayfrom
Boston, Massachusetts
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Rigshospitalet

Blegdamsvej 9, 2100 København, Denmark

Terminated/Withdrawn
3,657 miles (5,885 km)  awayfrom
Boston, Massachusetts
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"Hôpital Morvan CHRU de Brest"

2 Avenue Foch, 29200 Brest, France

Terminated/Withdrawn
3,155 miles (5,077 km)  awayfrom
Boston, Massachusetts
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Centre Hospitalier Générale - CTH

Maternité, Rue Lucien Biset, 73000 Chambéry, France

Terminated/Withdrawn
3,682 miles (5,926 km)  awayfrom
Boston, Massachusetts
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CTRH - CHU Bocage

21000 Dijon, France

Terminated/Withdrawn
3,593 miles (5,782 km)  awayfrom
Boston, Massachusetts
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Hôpital André Mignot

177 Rue de Versailles, 78150 Le Chesnay, France

Terminated/Withdrawn
3,428 miles (5,517 km)  awayfrom
Boston, Massachusetts
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CHRU Hôtel Dieu - CRTH

1 Place Alexis-Ricordeau, 44093 Nantes, France

Terminated/Withdrawn
3,311 miles (5,328 km)  awayfrom
Boston, Massachusetts
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Hôpital Cochin

27 Rue du Faubourg Saint-Jacques, 75014 Paris, France

Terminated/Withdrawn
3,437 miles (5,531 km)  awayfrom
Boston, Massachusetts
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CHU de Reims Hôpital Maison Blanche - CRTH

45 Rue Cognacq-Jay, 51092 Reims, France

Terminated/Withdrawn
3,497 miles (5,628 km)  awayfrom
Boston, Massachusetts
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Centre Régional de Traitement de l'Hémophilie et des Maladies hémorragiques. CHU de Rennes - Hôpital Pontchaillou

2 Rue Henri le Guilloux, 35000 Rennes, France

Terminated/Withdrawn
3,282 miles (5,282 km)  awayfrom
Boston, Massachusetts
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CHRU Charles Nicolle

37 Boulevard Gambetta, 76000 Rouen, France

Terminated/Withdrawn
3,370 miles (5,423 km)  awayfrom
Boston, Massachusetts
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CHRU Purpan CRTH - Pavillon Sénac

9, 9 Place Lange, 31300 Toulouse, France

Terminated/Withdrawn
3,543 miles (5,701 km)  awayfrom
Boston, Massachusetts
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Jósa András County Hospital

Nyíregyháza, Jósa András u., 4400 Hungary

Terminated/Withdrawn
4,253 miles (6,844 km)  awayfrom
Boston, Massachusetts
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Markusovszky Hospital

Szombathely, Markusovszky Lajos u. 5, 9700 Hungary

Terminated/Withdrawn
4,076 miles (6,560 km)  awayfrom
Boston, Massachusetts
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Policlinico Universitario Gemelli

Via della Pineta Sacchetti, 217, 00168 Roma RM, Italy

Terminated/Withdrawn
4,088 miles (6,578 km)  awayfrom
Boston, Massachusetts
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Szpital Uniwersytecki nr 1 im. dr Andrzeja Jurasza

Marii Skłodowskiej Curie 9, 85-094 Bydgoszcz, Poland

Terminated/Withdrawn
3,931 miles (6,327 km)  awayfrom
Boston, Massachusetts
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Samodzielny Publiczny Szpital Kliniczny nr 1

Gdańsk, Poland

Terminated/Withdrawn
3,914 miles (6,299 km)  awayfrom
Boston, Massachusetts
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Samodzielny Publiczny Dzieciecy Szpital Kliniczny

Żwirki i Wigury 63A, 02-091 Warszawa, Poland

Terminated/Withdrawn
4,070 miles (6,551 km)  awayfrom
Boston, Massachusetts
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Uniwersytecki Szpital Kliniczny we Wrocławiu

Borowska 213, 50-556 Wrocław, Poland

Terminated/Withdrawn
3,962 miles (6,376 km)  awayfrom
Boston, Massachusetts
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Centro Hospitalar Lisboa Norte Hospital de Sta. Maria

Av. Prof. Egas Moniz MB, 1649-028 Lisboa, Portugal

Terminated/Withdrawn
3,186 miles (5,128 km)  awayfrom
Boston, Massachusetts
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Centro Hospitalar de São João, E.P.E.

Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

Terminated/Withdrawn
3,144 miles (5,060 km)  awayfrom
Boston, Massachusetts
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Federal State Budget Institution "Hematology Research Center" of Ministry of Healthcare of Russian Federation

Moscow, Russia, 125167

Terminated/Withdrawn
4,482 miles (7,212 km)  awayfrom
Boston, Massachusetts
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University Medical Centre Ljubljana

Zaloška cesta 7, 1000 Ljubljana, Slovenia

Terminated/Withdrawn
4,032 miles (6,489 km)  awayfrom
Boston, Massachusetts
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Sahlgrenska University Hospital

Blå stråket 5, 413 45 Göteborg, Sweden

Terminated/Withdrawn
3,584 miles (5,768 km)  awayfrom
Boston, Massachusetts
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Kliniska studier i Sverige - Forum Söder

Skånes universitetssjukhus, Akutgatan 8, 221 85 Lund, Sweden

Terminated/Withdrawn
3,679 miles (5,921 km)  awayfrom
Boston, Massachusetts
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Universitätsspital Basel

Universitätsspital CH, Petersgraben 4, 4031 Basel, Switzerland

Terminated/Withdrawn
3,693 miles (5,944 km)  awayfrom
Boston, Massachusetts
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Centre Hospitalier Universitaire Vaudois

Rue du Bugnon 46, 1011 Lausanne, Switzerland

Terminated/Withdrawn
3,684 miles (5,929 km)  awayfrom
Boston, Massachusetts
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Luzerner Kantonsspital

Spitalstrasse, 6004 Luzern, Switzerland

Terminated/Withdrawn
3,739 miles (6,017 km)  awayfrom
Boston, Massachusetts
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Kantonsspital St. Gallen

Rorschacher Str. 95, 9001 St. Gallen, Switzerland

Terminated/Withdrawn
3,773 miles (6,072 km)  awayfrom
Boston, Massachusetts
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FMH Kinder und Jugendmedizin, im Wabern-Zentrum

Wabern bei Bern, 3084 Köniz, Switzerland

Terminated/Withdrawn
3,707 miles (5,965 km)  awayfrom
Boston, Massachusetts
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Kinderspital Zürich

Steinwiesstrasse 75, 8032 Zürich, Switzerland

Terminated/Withdrawn
3,740 miles (6,019 km)  awayfrom
Boston, Massachusetts
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Cambridge University Hospital NHS Foundation Trust, Addenbrooke's Hospital

Hills Rd, Cambridge CB2 0QQ, UK

Terminated/Withdrawn
3,267 miles (5,258 km)  awayfrom
Boston, Massachusetts
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UMHAP Sveti Georgï EAD

Plovdiv, Bulgaria

Terminated/Withdrawn
4,604 miles (7,409 km)  awayfrom
Boston, Massachusetts
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The Affiliated Hospital of Medical College, Qingdao University

16 Jiangsu Rd, Shinan Qu, Qingdao Shi, Shandong Sheng, China

Terminated/Withdrawn
6,970 miles (11,217 km)  awayfrom
Boston, Massachusetts
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CHRU Pellegrin

33076 Bordeaux, France

Terminated/Withdrawn
3,415 miles (5,497 km)  awayfrom
Boston, Massachusetts
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View all (112)
Trial Protocol ID: 061001
Back to Trial Summary