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ADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD)

IDENTIFIERS
Trial Protocol: 061001
Clinicaltrials.gov: NCT02078427
PURPOSE

The purpose of the study is to document the natural history of hemophilia A disease and long-term outcomes in terms of effectiveness, safety and quality of life in participants receiving Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) in routine clinical practice

Recruiting
AU
AT
BE
20+
BR
BG
CA
CN
CO
CZ
DK
FR
GR
HU
IT
NO
PL
PT
RU
SI
ES
SE
CH
GB

Trial at a glance

What medical condition is being studied?   Hemophilia A
What is the trial testing?   ADVATE Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (octocog alfa; rAHF-PFM); ADYNOVI Antihemophilic Factor (Recombinant) Pegylated (rurioctocog alfa pegol; rAHF-PEG)
How many participants are being enrolled?   1130
When is the trial being conducted?    - 
How long is participation in the trial?   a. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) alone b. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) alone with a minimum follow up time of 4 years c. Up to approximately 12 years for currently enrolled subjects treated with rAHF-PFM and subsequently switched to rAHF-PEG (i.e. up to approx. 8 years on rAHF-PFM and at least 4 years on rAHF-PEG)

Key requirements

Sex   
All
Age   
All
Accepts Healthy Volunteers?   
No

Trial Details / Participation Requirements

CLICK TO EXPANDCLICK TO COLLAPSE
Trial Type:   Observational
Trial Arms/Groups or Cohorts:   
rAHF-PFM: Participants treated with rAHF-PFM alone
rAHF-PEG: Participants treated with rAHF-PEG alone
rAHF-PFM then rAHF-PEG: Participants treated with rAHF-PFM and subsequently switched to rAHF-PEG
Intervention:   ADVATE Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (octocog alfa; rAHF-PFM); ADYNOVI Antihemophilic Factor (Recombinant) Pegylated (rurioctocog alfa pegol; rAHF-PEG)
Primary Outcome Measure(s):
Joint Health Outcomes - Assessed by Physical Exam Using Only the Pain, Bleeding, and Physical Exam Parameters of the Gilbert Scale [Time Frame: Up to approximately 12 years]
Secondary Outcome Measure(s):   
Annualized Bleed Rate, All Joints [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized Bleed Rate, All Bleeds [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized bleed rate, pre-existing target joints at baseline [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of New Target Joints [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health by X-ray by Pettersson scale [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit.]
Status of Joint Health by Magnetic Resonance Imaging (MRI) Scoring System- Using The Lund Scoring System (LSS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health using the Hemophilia Joint Health Score (HJHS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for prophylaxis therapy [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Compliance with the dosing prescribed and its relationship with effectiveness [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Global effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG units required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG infusions required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of target joint intervention, including surgery, radiosynovectomy, and chemosynovectomy [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of pseudo tumor development [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: HAL questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-12v2 questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D questionnaire - for adult patients [Time Frame: Enrollment visit;Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: PedHAL questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-10 questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D (14 and up) questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Chronic pain associated with hemophilia, as measured over a period of 4 weeks on an annual basis, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Acute pain associated with hemophilia, as measured with individual bleeding episodes, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Number of days lost from school or work due to bleeding episodes [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 1 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 2 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels Lesser than (<)1%, Lesser Than or Equal to (<=) 2%, and <= 5% without history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% with history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Untreated Patient (PUPs) and Minimally Treated Patients (MTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related non-serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of inhibitors after switching to rAHF-PEG [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Entry Criteria:
Inclusion Criteria: • Participant has hemophilia A (FVIII ≤5%) • Participant is prescribed Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) by the treating physician • Participant or participant’s legally authorized representative provides informed consent Exclusion Criteria: • Participant has known hypersensitivity to the active substance or any of the excipients • Participant has known allergic reaction to mouse or hamster proteins • Participant has participated in another clinical study involving an investigational product (IP) or device within 30 days prior to study enrollment or is scheduled to participate in another clinical study involving another FVIII concentrate or device during the course of this study

Trial Locations

Any
Completed
Terminated
Recruiting
Withdrawn
Suspended
Any
RESULTS
Kepler Universitätsklinikum Klinik für Kinder-und Jugendheilkunde

Krankenhausstraße 9, 4020 Linz, Austria

Recruiting
3,985 miles (6,413 km)  awayfrom
Massachusetts, United States
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Medizinische Universitaet Wien

Spitalgasse 23, 1090 Wien, Austria

Recruiting
4,069 miles (6,549 km)  awayfrom
Massachusetts, United States
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Hemoce - Ce

Av. José Bastos, 3390 - Rodolfo Teófilo, Fortaleza - CE, 60431-086, Brazil

Recruiting
3,808 miles (6,129 km)  awayfrom
Massachusetts, United States
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Hemocentro do Espírito Santo

Av. Mal. Campos, 1468 - Nazareth, Vitória - ES, 29047-105, Brazil

Site Contact
Recruiting
4,774 miles (7,683 km)  awayfrom
Massachusetts, United States
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Hemocentro da UNICAMP

Universidade Estadual de Campinas - R. Carlos Chagas, 480 - Cidade Universitária, Campinas - SP, 13083-878, Brazil

Recruiting
4,773 miles (7,682 km)  awayfrom
Massachusetts, United States
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Hemocentro Ribeirão Preto - SP

Rua Tenente Catão Roxo, 2501 Entrada pela - R. Prof. Hélio Lourenço - Vila Monte Alegre, Ribeirão Preto - SP, 14051-060, Brazil

Recruiting
4,648 miles (7,480 km)  awayfrom
Massachusetts, United States
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Hemepar - Pr

Tv. João Prosdócimo, 145 - Alto da XV, Curitiba - PR, 80045-145, Brazil

Recruiting
4,899 miles (7,885 km)  awayfrom
Massachusetts, United States
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Hemorgs - Rs

Av. Bento Gonçalves, 3722 - Partenon, Porto Alegre - RS, 90650-001, Brazil

Recruiting
5,173 miles (8,325 km)  awayfrom
Massachusetts, United States
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Hemorio - Rj

R. Frei Caneca, 8 - Centro, Rio de Janeiro - RJ, 20211-030, Brazil

Recruiting
4,866 miles (7,831 km)  awayfrom
Massachusetts, United States
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Faculdade de Medicina da Universidade de São Paulo

Pacaembu, São Paulo - State of São Paulo, 05403, Brazil

Recruiting
4,829 miles (7,771 km)  awayfrom
Massachusetts, United States
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Children's Hospital of Eastern Ontario

401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Recruiting
281 miles (453 km)  awayfrom
Massachusetts, United States
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St-Michael's Hospital

30 Bond St, Toronto, ON M5B 1W8, Canada

Site Contact
Recruiting
386 miles (621 km)  awayfrom
Massachusetts, United States
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Sick Kids Hospital

555 University Ave, Toronto, ON M5G 1X8, Canada

Recruiting
386 miles (622 km)  awayfrom
Massachusetts, United States
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Royal University Hospital

103 Hospital Dr, Saskatoon, SK S7N 0W8, Canada

Recruiting
1,742 miles (2,803 km)  awayfrom
Massachusetts, United States
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Nanfang Hospital Affiliated to Nanfang Medical University

1838 Guangzhou N Ave, Baiyun Qu, Guangzhou Shi, Guangdong Sheng, China

Site Contact
Recruiting
7,898 miles (12,710 km)  awayfrom
Massachusetts, United States
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The Affiliated Hospital of Xuzhou Medical University

Yunlong District, Xuzhou, China

Site Contact
Recruiting
7,113 miles (11,447 km)  awayfrom
Massachusetts, United States
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The Blood Center of Shandong Province

Jinan, Shandong, China

Recruiting
6,950 miles (11,185 km)  awayfrom
Massachusetts, United States
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Shenzhen Second People's Hospital

3002 Sungang W Rd, Futian Qu, Shenzhen Shi, Guangdong Sheng, China

Recruiting
7,937 miles (12,774 km)  awayfrom
Massachusetts, United States
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Fundación Oftalmológica de Santander FOSCAL

Cl. 157 #23-99, Floridablanca, Santander, Colombia

Recruiting
2,436 miles (3,921 km)  awayfrom
Massachusetts, United States
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SBHI Chelyabinsk Regional Children's Clinical Hospital

Chelyabinsk, Chelyabinsk Oblast, Russia

Site Contact
Recruiting
5,167 miles (8,315 km)  awayfrom
Massachusetts, United States
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SBHI of the Republic of Kareliya Republican Hospital n.a. V.A. Baranov

Petrozavodsk, Republic of Karelia, Russia

Recruiting
4,168 miles (6,708 km)  awayfrom
Massachusetts, United States
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State Budget Healthcare Institution of Saint-Petersburg "City polyclinic #37"

St Petersburg, Russia, 191186

Recruiting
4,128 miles (6,643 km)  awayfrom
Massachusetts, United States
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Hospital Teresa Herrera-Materno Infantil

As, Xubias de Abaixo, s/n, 15009 A Coruña, Spain

Recruiting
3,141 miles (5,055 km)  awayfrom
Massachusetts, United States
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Hospital Universitari Vall d'Hebron (HUVH)

Passeig de la Vall d'Hebron, 119, 08035 Barcelona, Spain

Recruiting
3,684 miles (5,929 km)  awayfrom
Massachusetts, United States
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Hospital Hospital Sant Joan de Déu

Hospital Sant Joan de Déu, 08950, Barcelona, Spain

Recruiting
3,683 miles (5,928 km)  awayfrom
Massachusetts, United States
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Hospital Universitario Son Espases

Carretera de Valldemossa, 79, 07120 Palma, Illes Balears, Spain

Recruiting
3,767 miles (6,062 km)  awayfrom
Massachusetts, United States
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Sahlgrenska University Hospital

Blå stråket 5, 413 45 Göteborg, Sweden

Recruiting
3,617 miles (5,821 km)  awayfrom
Massachusetts, United States
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Kliniska studier i Sverige - Forum Söder

Skånes universitetssjukhus, Akutgatan 8, 221 85 Lund, Sweden

Recruiting
3,713 miles (5,976 km)  awayfrom
Massachusetts, United States
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Karolinska Universitetssjukhuset Solna

Karolinska Vägen 22, 171 64 Solna, Sweden

Recruiting
3,772 miles (6,071 km)  awayfrom
Massachusetts, United States
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Inselspital Bern

Freiburgstrasse 18, 3010 Bern, Switzerland

Recruiting
3,745 miles (6,026 km)  awayfrom
Massachusetts, United States
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Luzerner Kantonsspital

Spitalstrasse, 6004 Luzern, Switzerland

Recruiting
3,778 miles (6,080 km)  awayfrom
Massachusetts, United States
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Kantonsspital St. Gallen

Rorschacher Str. 95, 9001 St. Gallen, Switzerland

Recruiting
3,812 miles (6,135 km)  awayfrom
Massachusetts, United States
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Universitätsspital Zürich

Rämistrasse 100, 8091 Zürich, Switzerland

Recruiting
3,779 miles (6,081 km)  awayfrom
Massachusetts, United States
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Hampshire Hospitals NHS Foundation Trust, Basingstoke and North Hampshire Hospital

Aldermaston Rd, Basingstoke RG24 9NA, UK

Recruiting
3,274 miles (5,269 km)  awayfrom
Massachusetts, United States
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East Kent Hospitals University Foundation Trust, Kent & Canterbury Hospital

Ethelbert Rd, Canterbury CT1 3NG, UK

Recruiting
3,364 miles (5,414 km)  awayfrom
Massachusetts, United States
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Great Ormond Street Hospital for Children NHS Trust

Great Ormond Street, Holborn, London WC1N 3JH, UK

Recruiting
3,309 miles (5,326 km)  awayfrom
Massachusetts, United States
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Stollery Children's Hospital, University of Alberta

Edmonton, AB T6G 2B7, Canada

Currently On Hold
2,039 miles (3,281 km)  awayfrom
Massachusetts, United States
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Royal Prince Alfred Hospital

50 Missenden Rd, Camperdown NSW 2050, Australia

10,047 miles (16,168 km)  awayfrom
Massachusetts, United States
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Landes Frauen und Kinderklinik Linz (LFKK Linz)

Landes-Kinderklinik, Krankenhausstraße, 4020 Linz, Austria

3,985 miles (6,413 km)  awayfrom
Massachusetts, United States
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Fundação HEMOPA

Tv. Padre Eutíquio, 2109 - Batista Campos, Belém - PA, 66033-000, Brazil

3,360 miles (5,408 km)  awayfrom
Massachusetts, United States
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Fakultní nemocnice Brno

Jihlavská 340/20, 625 00 Brno-Bohunice-Brno-Starý Lískovec, Czechia

4,045 miles (6,509 km)  awayfrom
Massachusetts, United States
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Fakultní nemocnice Ostrava, Krevní centrum

17. listopadu 833/9, 708 00 Ostrava-Poruba, Czechia

4,084 miles (6,572 km)  awayfrom
Massachusetts, United States
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Fakultní nemocnice Ostrava, Oddělení dětské hematologie a hematoonkologie

17. listopadu 1790, 708 00 Ostrava-Poruba, Czechia

4,084 miles (6,572 km)  awayfrom
Massachusetts, United States
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Fakultní nemocnice v Motole

V Úvalu 84, 150 06 Praha 5, Czechia

3,927 miles (6,320 km)  awayfrom
Massachusetts, United States
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Rigshospitalet

Blegdamsvej 9, 2100 København, Denmark

3,691 miles (5,940 km)  awayfrom
Massachusetts, United States
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CHU Côte de Nacre - CRTH

Avenue de la Côte de Nacre, 14000 Caen, France

3,353 miles (5,397 km)  awayfrom
Massachusetts, United States
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Hôpital André Mignot

177 Rue de Versailles, 78150 Le Chesnay, France

3,467 miles (5,580 km)  awayfrom
Massachusetts, United States
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Hôpital de la Mère et de l'Enfant - CHU de LIMOGES

8 Avenue Dominique Larrey, 87000 Limoges, France

3,511 miles (5,651 km)  awayfrom
Massachusetts, United States
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CHU de Reims Hôpital Maison Blanche - CRTH

45 Rue Cognacq-Jay, 51092 Reims, France

3,536 miles (5,691 km)  awayfrom
Massachusetts, United States
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CIC

2 Allée des Artilleurs, 42000 Saint-Étienne, France

3,659 miles (5,888 km)  awayfrom
Massachusetts, United States
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Aghia Sofia Children's Hospital

Thivon 1, Athina 115 27, Greece

4,776 miles (7,687 km)  awayfrom
Massachusetts, United States
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Laikon General Hospital

Goudi, Athens 115 27, Greece

4,776 miles (7,687 km)  awayfrom
Massachusetts, United States
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General Hospital of Thessaloniki "Ippokratio"

Konstantinoupoleos 49, Thessaloniki 546 42, Greece

4,632 miles (7,454 km)  awayfrom
Massachusetts, United States
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Heim Pál Gyermekkórház

Budapest, Üllői út 86, 1089 Hungary

4,204 miles (6,766 km)  awayfrom
Massachusetts, United States
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Debreceni Egyetem Klinikai Kozpont

Debrecen, Nagyerdei krt. 98, 4032 Hungary

4,301 miles (6,922 km)  awayfrom
Massachusetts, United States
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Mohács City Hospital

Mohács, Szepessy tér 7, 7700 Hungary

4,243 miles (6,828 km)  awayfrom
Massachusetts, United States
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Azienda Ospedaliera Policlinico Consorziale Di Bari

Piazza Giulio Cesare, 11, 70124 Bari BA, Italy

4,352 miles (7,004 km)  awayfrom
Massachusetts, United States
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Policlinico S Orsola Malpighi

Via Giuseppe Massarenti, 9, 40138 Bologna BO, Italy

3,992 miles (6,425 km)  awayfrom
Massachusetts, United States
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Azienda Ospedaliera Universitaria Vittorio Emanuele, Ferrarotto, S. Bambino

Via Salvatore Citelli, 1, 95124 Catania CT, Italy

4,413 miles (7,102 km)  awayfrom
Massachusetts, United States
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Ospedale Pugliese -Ciaccio

Viale Papa Pio X, 83, 88100 Catanzaro CZ, Italy

4,425 miles (7,122 km)  awayfrom
Massachusetts, United States
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Az. Osp. Univ. Careggi

Largo Piero Palagi, 1, 50139 Firenze FI, Italy

4,011 miles (6,455 km)  awayfrom
Massachusetts, United States
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Ospedale di Macerata

Via Santa Lucia, 2, 62100 Macerata MC, Italy

4,124 miles (6,637 km)  awayfrom
Massachusetts, United States
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Via della Commenda, 10, 20122 Milano MI, Italy

3,867 miles (6,224 km)  awayfrom
Massachusetts, United States
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Azienda Ospedaliera Universitaria Federico II

Via Sergio Pansini, 5, 80131 Napoli NA, Italy

4,246 miles (6,834 km)  awayfrom
Massachusetts, United States
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Azienda Ospedaliera di Padova Clinica Medica II

Via Gustavo Modena, 9, 35128 Padova PD, Italy

3,983 miles (6,411 km)  awayfrom
Massachusetts, United States
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AOUP P. Giaccone

Via del Vespro, 129, 90127 Palermo PA, Italy

4,313 miles (6,941 km)  awayfrom
Massachusetts, United States
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Azienda Ospedaliera Bianchi Melacrino Morelli

Via Giuseppe Melacrino, 21, 89124 Reggio Calabria RC, Italy

4,416 miles (7,107 km)  awayfrom
Massachusetts, United States
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Università degli studi di Roma "La Sapienza"

Viale Regina Elena, 334, 00161 Roma RM, Italy

4,133 miles (6,652 km)  awayfrom
Massachusetts, United States
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Ospedale Pediatrico Bambino Gesù

Piazza di Sant'Onofrio, 4, 00165 Roma RM, Italy

4,131 miles (6,648 km)  awayfrom
Massachusetts, United States
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Centro Emofilia e Coagulopatie Rare

73020 Scorrano, Province of Lecce, Italy

4,454 miles (7,168 km)  awayfrom
Massachusetts, United States
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Ospedale Molinette

Via Cherasco, 15, 10126 Torino TO, Italy

3,815 miles (6,140 km)  awayfrom
Massachusetts, United States
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Rikshospitalet

Sognsvannsveien 20, 0372 Oslo, Norway

3,520 miles (5,665 km)  awayfrom
Massachusetts, United States
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Rikshospitalet, Oslo University Hospital

Sognsvannsveien 20, 0372 Oslo, Norway

3,520 miles (5,665 km)  awayfrom
Massachusetts, United States
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Hospital do Divino Espírito Santo

Av. D. Manuel I, 9500-370 Ponta Delgada, Portugal

2,438 miles (3,924 km)  awayfrom
Massachusetts, United States
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Centro Hospitalar e Universitade de Coimbra

Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal

3,224 miles (5,189 km)  awayfrom
Massachusetts, United States
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Federal State Budget Institution "Hematology Research Center" of Ministry of Healthcare of Russian Federation

Moscow, Russia, 125167

4,511 miles (7,259 km)  awayfrom
Massachusetts, United States
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University Medical Centre Ljubljana

Zaloška cesta 7, 1000 Ljubljana, Slovenia

4,071 miles (6,551 km)  awayfrom
Massachusetts, United States
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South Metropolitan Health Service trading as Fiona Stanley Hospital

14 Barry Marshall Parade, Murdoch WA 6150, Australia

11,609 miles (18,682 km)  awayfrom
Massachusetts, United States
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Cliniques Universitaires Saint-Luc

Avenue Hippocrate 10, 1200 Bruxelles, Belgium

3,511 miles (5,650 km)  awayfrom
Massachusetts, United States
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The Moncton City Hospital

135 Macbeath Ave, Moncton, NB E1C 6Z8, Canada

440 miles (708 km)  awayfrom
Massachusetts, United States
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"Hôpital Morvan CHRU de Brest"

2 Avenue Foch, 29200 Brest, France

3,195 miles (5,143 km)  awayfrom
Massachusetts, United States
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Centre Hospitalier Générale - CTH

Maternité, Rue Lucien Biset, 73000 Chambéry, France

3,723 miles (5,991 km)  awayfrom
Massachusetts, United States
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CTRH - CHU Bocage

21000 Dijon, France

3,632 miles (5,846 km)  awayfrom
Massachusetts, United States
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CHRU Hôtel Dieu - CRTH

1 Place Alexis-Ricordeau, 44093 Nantes, France

3,351 miles (5,393 km)  awayfrom
Massachusetts, United States
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Hôpital Cochin

27 Rue du Faubourg Saint-Jacques, 75014 Paris, France

3,476 miles (5,595 km)  awayfrom
Massachusetts, United States
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Centre Régional de Traitement de l'Hémophilie et des Maladies hémorragiques. CHU de Rennes - Hôpital Pontchaillou

2 Rue Henri le Guilloux, 35000 Rennes, France

3,323 miles (5,347 km)  awayfrom
Massachusetts, United States
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CHRU Charles Nicolle

37 Boulevard Gambetta, 76000 Rouen, France

3,409 miles (5,487 km)  awayfrom
Massachusetts, United States
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CHRU Purpan CRTH - Pavillon Sénac

9, 9 Place Lange, 31300 Toulouse, France

3,584 miles (5,769 km)  awayfrom
Massachusetts, United States
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Jósa András County Hospital

Nyíregyháza, Jósa András u., 4400 Hungary

4,289 miles (6,903 km)  awayfrom
Massachusetts, United States
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Markusovszky Hospital

Szombathely, Markusovszky Lajos u. 5, 9700 Hungary

4,114 miles (6,622 km)  awayfrom
Massachusetts, United States
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Policlinico Universitario Gemelli

Via della Pineta Sacchetti, 217, 00168 Roma RM, Italy

4,128 miles (6,644 km)  awayfrom
Massachusetts, United States
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Szpital Uniwersytecki nr 1 im. dr Andrzeja Jurasza

Marii Skłodowskiej Curie 9, 85-094 Bydgoszcz, Poland

3,966 miles (6,383 km)  awayfrom
Massachusetts, United States
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Samodzielny Publiczny Szpital Kliniczny nr 1

Gdańsk, Poland

3,948 miles (6,354 km)  awayfrom
Massachusetts, United States
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Samodzielny Publiczny Dzieciecy Szpital Kliniczny

Żwirki i Wigury 63A, 02-091 Warszawa, Poland

4,105 miles (6,607 km)  awayfrom
Massachusetts, United States
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Uniwersytecki Szpital Kliniczny we Wrocławiu

Borowska 213, 50-556 Wrocław, Poland

3,998 miles (6,434 km)  awayfrom
Massachusetts, United States
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Centro Hospitalar Lisboa Norte Hospital de Sta. Maria

Av. Prof. Egas Moniz MB, 1649-028 Lisboa, Portugal

3,231 miles (5,200 km)  awayfrom
Massachusetts, United States
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Centro Hospitalar de São João, E.P.E.

Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

3,188 miles (5,131 km)  awayfrom
Massachusetts, United States
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Universitätsspital Basel

Universitätsspital CH, Petersgraben 4, 4031 Basel, Switzerland

3,733 miles (6,007 km)  awayfrom
Massachusetts, United States
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Centre Hospitalier Universitaire Vaudois

Rue du Bugnon 46, 1011 Lausanne, Switzerland

3,724 miles (5,994 km)  awayfrom
Massachusetts, United States
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FMH Kinder und Jugendmedizin, im Wabern-Zentrum

Wabern bei Bern, 3084 Köniz, Switzerland

3,746 miles (6,029 km)  awayfrom
Massachusetts, United States
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Kinderspital Zürich

Steinwiesstrasse 75, 8032 Zürich, Switzerland

3,779 miles (6,082 km)  awayfrom
Massachusetts, United States
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Cambridge University Hospital NHS Foundation Trust, Addenbrooke's Hospital

Hills Rd, Cambridge CB2 0QQ, UK

3,305 miles (5,320 km)  awayfrom
Massachusetts, United States
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UMHAP Sveti Georgï EAD

Plovdiv, Bulgaria

4,642 miles (7,471 km)  awayfrom
Massachusetts, United States
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The Affiliated Hospital of Medical College, Qingdao University

16 Jiangsu Rd, Shinan Qu, Qingdao Shi, Shandong Sheng, China

6,965 miles (11,209 km)  awayfrom
Massachusetts, United States
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CHRU Pellegrin

33076 Bordeaux, France

3,457 miles (5,564 km)  awayfrom
Massachusetts, United States
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View all (105)
Trial Protocol ID: 061001
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