Takeda's Response to COVID-19 If you were diagnosed with COVID-19 and have recovered, you may be able to help in furthering research into a potential therapy for others by donating your plasma.

ADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD)

IDENTIFIERS
Trial Protocol: 061001
Clinicaltrials.gov: NCT02078427
PURPOSE

The purpose of the study is to document the natural history of hemophilia A disease and long-term outcomes in terms of effectiveness, safety and quality of life in participants receiving Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) in routine clinical practice

Recruiting
AU
AT
BE
20+
BR
BG
CA
CN
CO
CZ
DK
FR
GR
HU
IT
NO
PL
PT
RU
SI
ES
SE
CH
GB

Trial at a glance

What medical condition is being studied?   Hemophilia A
What is the trial testing?   ADVATE Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (octocog alfa; rAHF-PFM); ADYNOVI Antihemophilic Factor (Recombinant) Pegylated (rurioctocog alfa pegol; rAHF-PEG)
How many participants are being enrolled?   1130
When is the trial being conducted?    - 
How long is participation in the trial?   a. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) alone b. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) alone with a minimum follow up time of 4 years c. Up to approximately 12 years for currently enrolled subjects treated with rAHF-PFM and subsequently switched to rAHF-PEG (i.e. up to approx. 8 years on rAHF-PFM and at least 4 years on rAHF-PEG)

Key requirements

Sex   
All
Age   
All
Accepts Healthy Volunteers?   
No

Trial Details / Participation Requirements

CLICK TO EXPANDCLICK TO COLLAPSE
Trial Type:   Observational
Trial Arms/Groups or Cohorts:   
rAHF-PFM: Participants treated with rAHF-PFM alone
rAHF-PEG: Participants treated with rAHF-PEG alone
rAHF-PFM then rAHF-PEG: Participants treated with rAHF-PFM and subsequently switched to rAHF-PEG
Intervention:   ADVATE Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (octocog alfa; rAHF-PFM); ADYNOVI Antihemophilic Factor (Recombinant) Pegylated (rurioctocog alfa pegol; rAHF-PEG)
Primary Outcome Measure(s):
Joint Health Outcomes - Assessed by Physical Exam Using Only the Pain, Bleeding, and Physical Exam Parameters of the Gilbert Scale [Time Frame: Up to approximately 12 years]
Secondary Outcome Measure(s):   
Annualized Bleed Rate, All Joints [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized Bleed Rate, All Bleeds [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized bleed rate, pre-existing target joints at baseline [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of New Target Joints [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health by X-ray by Pettersson scale [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit.]
Status of Joint Health by Magnetic Resonance Imaging (MRI) Scoring System- Using The Lund Scoring System (LSS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health using the Hemophilia Joint Health Score (HJHS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for prophylaxis therapy [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Compliance with the dosing prescribed and its relationship with effectiveness [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Global effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG units required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG infusions required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of target joint intervention, including surgery, radiosynovectomy, and chemosynovectomy [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of pseudo tumor development [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: HAL questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-12v2 questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D questionnaire - for adult patients [Time Frame: Enrollment visit;Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: PedHAL questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-10 questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D (14 and up) questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Chronic pain associated with hemophilia, as measured over a period of 4 weeks on an annual basis, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Acute pain associated with hemophilia, as measured with individual bleeding episodes, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Number of days lost from school or work due to bleeding episodes [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 1 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 2 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels Lesser than (<)1%, Lesser Than or Equal to (<=) 2%, and <= 5% without history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% with history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Untreated Patient (PUPs) and Minimally Treated Patients (MTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related non-serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of inhibitors after switching to rAHF-PEG [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Entry Criteria:
Inclusion Criteria: • Participant has hemophilia A (FVIII ≤5%) • Participant is prescribed Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) by the treating physician • Participant or participant’s legally authorized representative provides informed consent Exclusion Criteria: • Participant has known hypersensitivity to the active substance or any of the excipients • Participant has known allergic reaction to mouse or hamster proteins • Participant has participated in another clinical study involving an investigational product (IP) or device within 30 days prior to study enrollment or is scheduled to participate in another clinical study involving another FVIII concentrate or device during the course of this study

Trial Locations

Any
Terminated
Completed
Recruiting
Withdrawn
Suspended
Any
RESULTS
Medizinische Universitaet Wien

Spitalgasse 23, 1090 Wien, Austria

Recruiting
4,218 miles (6,789 km)  awayfrom
New York City, New York
View on Map
Hemoce - Ce

Av. José Bastos, 3390 - Rodolfo Teófilo, Fortaleza - CE, 60431-086, Brazil

Recruiting
3,802 miles (6,119 km)  awayfrom
New York City, New York
View on Map
Hemocentro do Espírito Santo

Av. Mal. Campos, 1468 - Nazareth, Vitória - ES, 29047-105, Brazil

Site Contact
Recruiting
4,740 miles (7,629 km)  awayfrom
New York City, New York
View on Map
Hemepar - Pr

Tv. João Prosdócimo, 145 - Alto da XV, Curitiba - PR, 80045-145, Brazil

Recruiting
4,841 miles (7,790 km)  awayfrom
New York City, New York
View on Map
Hemorgs - Rs

Av. Bento Gonçalves, 3722 - Partenon, Porto Alegre - RS, 90650-001, Brazil

Recruiting
5,106 miles (8,218 km)  awayfrom
New York City, New York
View on Map
Hemocentro da UNICAMP

Universidade Estadual de Campinas - R. Carlos Chagas, 480 - Cidade Universitária, Campinas - SP, 13083-878, Brazil

Recruiting
4,722 miles (7,599 km)  awayfrom
New York City, New York
View on Map
Hemocentro Ribeirão Preto - SP

Rua Tenente Catão Roxo, 2501 Entrada pela - R. Prof. Hélio Lourenço - Vila Monte Alegre, Ribeirão Preto - SP, 14051-060, Brazil

Recruiting
4,596 miles (7,396 km)  awayfrom
New York City, New York
View on Map
Hemorio - Rj

R. Frei Caneca, 8 - Centro, Rio de Janeiro - RJ, 20211-030, Brazil

Recruiting
4,823 miles (7,762 km)  awayfrom
New York City, New York
View on Map
Faculdade de Medicina da Universidade de São Paulo

Pacaembu, São Paulo - State of São Paulo, 05403, Brazil

Recruiting
4,777 miles (7,688 km)  awayfrom
New York City, New York
View on Map
Children's Hospital of Eastern Ontario

401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Recruiting
331 miles (533 km)  awayfrom
New York City, New York
View on Map
St-Michael's Hospital

30 Bond St, Toronto, ON M5B 1W8, Canada

Site Contact
Recruiting
341 miles (548 km)  awayfrom
New York City, New York
View on Map
Sick Kids Hospital

555 University Ave, Toronto, ON M5G 1X8, Canada

Recruiting
341 miles (549 km)  awayfrom
New York City, New York
View on Map
Royal University Hospital

103 Hospital Dr, Saskatoon, SK S7N 0W8, Canada

Recruiting
1,722 miles (2,771 km)  awayfrom
New York City, New York
View on Map
Nanfang Hospital Affiliated to Nanfang Medical University

1838 Guangzhou N Ave, Baiyun Qu, Guangzhou Shi, Guangdong Sheng, China

Site Contact
Recruiting
7,993 miles (12,863 km)  awayfrom
New York City, New York
View on Map
The Affiliated Hospital of Xuzhou Medical University

Yunlong District, Xuzhou, China

Site Contact
Recruiting
7,203 miles (11,593 km)  awayfrom
New York City, New York
View on Map
The Blood Center of Shandong Province

Jinan, Shandong, China

Recruiting
7,041 miles (11,332 km)  awayfrom
New York City, New York
View on Map
Shenzhen Second People's Hospital

3002 Sungang W Rd, Futian Qu, Shenzhen Shi, Guangdong Sheng, China

Recruiting
8,031 miles (12,924 km)  awayfrom
New York City, New York
View on Map
Fundación Oftalmológica de Santander FOSCAL

Cl. 157 #23-99, Floridablanca, Santander, Colombia

Recruiting
2,329 miles (3,747 km)  awayfrom
New York City, New York
View on Map
SBHI Chelyabinsk Regional Children's Clinical Hospital

Chelyabinsk, Chelyabinsk Oblast, Russia

Site Contact
Recruiting
5,308 miles (8,543 km)  awayfrom
New York City, New York
View on Map
SBHI of the Republic of Kareliya Republican Hospital n.a. V.A. Baranov

Petrozavodsk, Republic of Karelia, Russia

Recruiting
4,314 miles (6,943 km)  awayfrom
New York City, New York
View on Map
State Budget Healthcare Institution of Saint-Petersburg "City polyclinic #37"

St Petersburg, Russia, 191186

Recruiting
4,275 miles (6,880 km)  awayfrom
New York City, New York
View on Map
Hospital Teresa Herrera-Materno Infantil

As, Xubias de Abaixo, s/n, 15009 A Coruña, Spain

Recruiting
3,281 miles (5,280 km)  awayfrom
New York City, New York
View on Map
Hospital Universitari Vall d'Hebron (HUVH)

Passeig de la Vall d'Hebron, 119, 08035 Barcelona, Spain

Recruiting
3,826 miles (6,157 km)  awayfrom
New York City, New York
View on Map
Hospital Hospital Sant Joan de Déu

Hospital Sant Joan de Déu, 08950, Barcelona, Spain

Recruiting
3,825 miles (6,156 km)  awayfrom
New York City, New York
View on Map
Hospital Universitario Son Espases

Carretera de Valldemossa, 79, 07120 Palma, Illes Balears, Spain

Recruiting
3,907 miles (6,288 km)  awayfrom
New York City, New York
View on Map
Sahlgrenska University Hospital

Blå stråket 5, 413 45 Göteborg, Sweden

Recruiting
3,767 miles (6,062 km)  awayfrom
New York City, New York
View on Map
Kliniska studier i Sverige - Forum Söder

Skånes universitetssjukhus, Akutgatan 8, 221 85 Lund, Sweden

Recruiting
3,863 miles (6,217 km)  awayfrom
New York City, New York
View on Map
Karolinska Universitetssjukhuset Solna

Karolinska Vägen 22, 171 64 Solna, Sweden

Recruiting
3,921 miles (6,311 km)  awayfrom
New York City, New York
View on Map
Inselspital Bern

Freiburgstrasse 18, 3010 Bern, Switzerland

Recruiting
3,892 miles (6,263 km)  awayfrom
New York City, New York
View on Map
Luzerner Kantonsspital

Spitalstrasse, 6004 Luzern, Switzerland

Recruiting
3,925 miles (6,317 km)  awayfrom
New York City, New York
View on Map
Universitätsspital Zürich

Rämistrasse 100, 8091 Zürich, Switzerland

Recruiting
3,926 miles (6,319 km)  awayfrom
New York City, New York
View on Map
Hampshire Hospitals NHS Foundation Trust, Basingstoke and North Hampshire Hospital

Aldermaston Rd, Basingstoke RG24 9NA, UK

Recruiting
3,422 miles (5,508 km)  awayfrom
New York City, New York
View on Map
East Kent Hospitals University Foundation Trust, Kent & Canterbury Hospital

Ethelbert Rd, Canterbury CT1 3NG, UK

Recruiting
3,513 miles (5,653 km)  awayfrom
New York City, New York
View on Map
Great Ormond Street Hospital for Children NHS Trust

Great Ormond Street, Holborn, London WC1N 3JH, UK

Recruiting
3,458 miles (5,565 km)  awayfrom
New York City, New York
View on Map
Stollery Children's Hospital, University of Alberta

Edmonton, AB T6G 2B7, Canada

Currently On Hold
2,023 miles (3,255 km)  awayfrom
New York City, New York
View on Map
Landes Frauen und Kinderklinik Linz (LFKK Linz)

Landes-Kinderklinik, Krankenhausstraße, 4020 Linz, Austria

Completed
4,134 miles (6,652 km)  awayfrom
New York City, New York
View on Map
Fundação HEMOPA

Tv. Padre Eutíquio, 2109 - Batista Campos, Belém - PA, 66033-000, Brazil

Completed
3,329 miles (5,357 km)  awayfrom
New York City, New York
View on Map
Fakultní nemocnice Brno

Jihlavská 340/20, 625 00 Brno-Bohunice-Brno-Starý Lískovec, Czechia

Completed
4,194 miles (6,750 km)  awayfrom
New York City, New York
View on Map
Fakultní nemocnice Ostrava, Krevní centrum

17. listopadu 833/9, 708 00 Ostrava-Poruba, Czechia

Completed
4,233 miles (6,813 km)  awayfrom
New York City, New York
View on Map
Fakultní nemocnice Ostrava, Oddělení dětské hematologie a hematoonkologie

17. listopadu 1790, 708 00 Ostrava-Poruba, Czechia

Completed
4,233 miles (6,813 km)  awayfrom
New York City, New York
View on Map
Fakultní nemocnice v Motole

V Úvalu 84, 150 06 Praha 5, Czechia

Completed
4,077 miles (6,561 km)  awayfrom
New York City, New York
View on Map
CHU Côte de Nacre - CRTH

Avenue de la Côte de Nacre, 14000 Caen, France

Completed
3,500 miles (5,633 km)  awayfrom
New York City, New York
View on Map
Hôpital de la Mère et de l'Enfant - CHU de LIMOGES

8 Avenue Dominique Larrey, 87000 Limoges, France

Completed
3,656 miles (5,885 km)  awayfrom
New York City, New York
View on Map
CHU de Reims Hôpital Maison Blanche - CRTH

45 Rue Cognacq-Jay, 51092 Reims, France

Completed
3,684 miles (5,929 km)  awayfrom
New York City, New York
View on Map
CIC

2 Allée des Artilleurs, 42000 Saint-Étienne, France

Completed
3,805 miles (6,123 km)  awayfrom
New York City, New York
View on Map
Aghia Sofia Children's Hospital

Thivon 1, Athina 115 27, Greece

Completed
4,923 miles (7,923 km)  awayfrom
New York City, New York
View on Map
Laikon General Hospital

Goudi, Athens 115 27, Greece

Completed
4,923 miles (7,923 km)  awayfrom
New York City, New York
View on Map
General Hospital of Thessaloniki "Ippokratio"

Konstantinoupoleos 49, Thessaloniki 546 42, Greece

Completed
4,779 miles (7,691 km)  awayfrom
New York City, New York
View on Map
Heim Pál Gyermekkórház

Budapest, Üllői út 86, 1089 Hungary

Completed
4,354 miles (7,006 km)  awayfrom
New York City, New York
View on Map
Debreceni Egyetem Klinikai Kozpont

Debrecen, Nagyerdei krt. 98, 4032 Hungary

Completed
4,450 miles (7,162 km)  awayfrom
New York City, New York
View on Map
Mohács City Hospital

Mohács, Szepessy tér 7, 7700 Hungary

Completed
4,391 miles (7,067 km)  awayfrom
New York City, New York
View on Map
Azienda Ospedaliera Policlinico Consorziale Di Bari

Piazza Giulio Cesare, 11, 70124 Bari BA, Italy

Completed
4,498 miles (7,239 km)  awayfrom
New York City, New York
View on Map
Policlinico S Orsola Malpighi

Via Giuseppe Massarenti, 9, 40138 Bologna BO, Italy

Completed
4,139 miles (6,661 km)  awayfrom
New York City, New York
View on Map
Azienda Ospedaliera Universitaria Vittorio Emanuele, Ferrarotto, S. Bambino

Via Salvatore Citelli, 1, 95124 Catania CT, Italy

Completed
4,557 miles (7,333 km)  awayfrom
New York City, New York
View on Map
Ospedale Pugliese -Ciaccio

Viale Papa Pio X, 83, 88100 Catanzaro CZ, Italy

Completed
4,570 miles (7,355 km)  awayfrom
New York City, New York
View on Map
Az. Osp. Univ. Careggi

Largo Piero Palagi, 1, 50139 Firenze FI, Italy

Completed
4,157 miles (6,690 km)  awayfrom
New York City, New York
View on Map
Ospedale di Macerata

Via Santa Lucia, 2, 62100 Macerata MC, Italy

Completed
4,270 miles (6,873 km)  awayfrom
New York City, New York
View on Map
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Via della Commenda, 10, 20122 Milano MI, Italy

Completed
4,014 miles (6,460 km)  awayfrom
New York City, New York
View on Map
Azienda Ospedaliera Universitaria Federico II

Via Sergio Pansini, 5, 80131 Napoli NA, Italy

Completed
4,392 miles (7,068 km)  awayfrom
New York City, New York
View on Map
Azienda Ospedaliera di Padova Clinica Medica II

Via Gustavo Modena, 9, 35128 Padova PD, Italy

Completed
4,131 miles (6,648 km)  awayfrom
New York City, New York
View on Map
AOUP P. Giaccone

Via del Vespro, 129, 90127 Palermo PA, Italy

Completed
4,456 miles (7,171 km)  awayfrom
New York City, New York
View on Map
Azienda Ospedaliera Bianchi Melacrino Morelli

Via Giuseppe Melacrino, 21, 89124 Reggio Calabria RC, Italy

Completed
4,560 miles (7,338 km)  awayfrom
New York City, New York
View on Map
Università degli studi di Roma "La Sapienza"

Viale Regina Elena, 334, 00161 Roma RM, Italy

Completed
4,279 miles (6,886 km)  awayfrom
New York City, New York
View on Map
Ospedale Pediatrico Bambino Gesù

Piazza di Sant'Onofrio, 4, 00165 Roma RM, Italy

Completed
4,277 miles (6,883 km)  awayfrom
New York City, New York
View on Map
Centro Emofilia e Coagulopatie Rare

73020 Scorrano, Province of Lecce, Italy

Completed
4,600 miles (7,403 km)  awayfrom
New York City, New York
View on Map
Ospedale Molinette

Via Cherasco, 15, 10126 Torino TO, Italy

Completed
3,961 miles (6,375 km)  awayfrom
New York City, New York
View on Map
Rikshospitalet

Sognsvannsveien 20, 0372 Oslo, Norway

Completed
3,670 miles (5,906 km)  awayfrom
New York City, New York
View on Map
Rikshospitalet, Oslo University Hospital

Sognsvannsveien 20, 0372 Oslo, Norway

Completed
3,670 miles (5,906 km)  awayfrom
New York City, New York
View on Map
Hospital do Divino Espírito Santo

Av. D. Manuel I, 9500-370 Ponta Delgada, Portugal

Completed
2,560 miles (4,120 km)  awayfrom
New York City, New York
View on Map
Centro Hospitalar e Universitade de Coimbra

Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal

Completed
3,360 miles (5,408 km)  awayfrom
New York City, New York
View on Map
University Medical Centre Ljubljana

Zaloška cesta 7, 1000 Ljubljana, Slovenia

Completed
4,219 miles (6,789 km)  awayfrom
New York City, New York
View on Map
Royal Prince Alfred Hospital

50 Missenden Rd, Camperdown NSW 2050, Australia

Terminated/Withdrawn
9,938 miles (15,994 km)  awayfrom
New York City, New York
View on Map
South Metropolitan Health Service trading as Fiona Stanley Hospital

14 Barry Marshall Parade, Murdoch WA 6150, Australia

Terminated/Withdrawn
11,625 miles (18,709 km)  awayfrom
New York City, New York
View on Map
Kepler Universitätsklinikum Klinik für Kinder-und Jugendheilkunde

Krankenhausstraße 9, 4020 Linz, Austria

Terminated/Withdrawn
4,133 miles (6,652 km)  awayfrom
New York City, New York
View on Map
Cliniques Universitaires Saint-Luc

Avenue Hippocrate 10, 1200 Bruxelles, Belgium

Terminated/Withdrawn
3,660 miles (5,889 km)  awayfrom
New York City, New York
View on Map
The Moncton City Hospital

135 Macbeath Ave, Moncton, NB E1C 6Z8, Canada

Terminated/Withdrawn
589 miles (948 km)  awayfrom
New York City, New York
View on Map
Rigshospitalet

Blegdamsvej 9, 2100 København, Denmark

Terminated/Withdrawn
3,841 miles (6,181 km)  awayfrom
New York City, New York
View on Map
"Hôpital Morvan CHRU de Brest"

2 Avenue Foch, 29200 Brest, France

Terminated/Withdrawn
3,341 miles (5,378 km)  awayfrom
New York City, New York
View on Map
Centre Hospitalier Générale - CTH

Maternité, Rue Lucien Biset, 73000 Chambéry, France

Terminated/Withdrawn
3,869 miles (6,226 km)  awayfrom
New York City, New York
View on Map
CTRH - CHU Bocage

21000 Dijon, France

Terminated/Withdrawn
3,779 miles (6,082 km)  awayfrom
New York City, New York
View on Map
Hôpital André Mignot

177 Rue de Versailles, 78150 Le Chesnay, France

Terminated/Withdrawn
3,615 miles (5,818 km)  awayfrom
New York City, New York
View on Map
CHRU Hôtel Dieu - CRTH

1 Place Alexis-Ricordeau, 44093 Nantes, France

Terminated/Withdrawn
3,497 miles (5,628 km)  awayfrom
New York City, New York
View on Map
Hôpital Cochin

27 Rue du Faubourg Saint-Jacques, 75014 Paris, France

Terminated/Withdrawn
3,624 miles (5,832 km)  awayfrom
New York City, New York
View on Map
Centre Régional de Traitement de l'Hémophilie et des Maladies hémorragiques. CHU de Rennes - Hôpital Pontchaillou

2 Rue Henri le Guilloux, 35000 Rennes, France

Terminated/Withdrawn
3,469 miles (5,583 km)  awayfrom
New York City, New York
View on Map
CHRU Charles Nicolle

37 Boulevard Gambetta, 76000 Rouen, France

Terminated/Withdrawn
3,557 miles (5,724 km)  awayfrom
New York City, New York
View on Map
CHRU Purpan CRTH - Pavillon Sénac

9, 9 Place Lange, 31300 Toulouse, France

Terminated/Withdrawn
3,728 miles (6,000 km)  awayfrom
New York City, New York
View on Map
Jósa András County Hospital

Nyíregyháza, Jósa András u., 4400 Hungary

Terminated/Withdrawn
4,439 miles (7,143 km)  awayfrom
New York City, New York
View on Map
Markusovszky Hospital

Szombathely, Markusovszky Lajos u. 5, 9700 Hungary

Terminated/Withdrawn
4,263 miles (6,861 km)  awayfrom
New York City, New York
View on Map
Policlinico Universitario Gemelli

Via della Pineta Sacchetti, 217, 00168 Roma RM, Italy

Terminated/Withdrawn
4,274 miles (6,878 km)  awayfrom
New York City, New York
View on Map
Szpital Uniwersytecki nr 1 im. dr Andrzeja Jurasza

Marii Skłodowskiej Curie 9, 85-094 Bydgoszcz, Poland

Terminated/Withdrawn
4,116 miles (6,624 km)  awayfrom
New York City, New York
View on Map
Samodzielny Publiczny Szpital Kliniczny nr 1

Gdańsk, Poland

Terminated/Withdrawn
4,098 miles (6,595 km)  awayfrom
New York City, New York
View on Map
Samodzielny Publiczny Dzieciecy Szpital Kliniczny

Żwirki i Wigury 63A, 02-091 Warszawa, Poland

Terminated/Withdrawn
4,255 miles (6,848 km)  awayfrom
New York City, New York
View on Map
Uniwersytecki Szpital Kliniczny we Wrocławiu

Borowska 213, 50-556 Wrocław, Poland

Terminated/Withdrawn
4,147 miles (6,675 km)  awayfrom
New York City, New York
View on Map
Centro Hospitalar Lisboa Norte Hospital de Sta. Maria

Av. Prof. Egas Moniz MB, 1649-028 Lisboa, Portugal

Terminated/Withdrawn
3,365 miles (5,415 km)  awayfrom
New York City, New York
View on Map
Centro Hospitalar de São João, E.P.E.

Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

Terminated/Withdrawn
3,325 miles (5,352 km)  awayfrom
New York City, New York
View on Map
Federal State Budget Institution "Hematology Research Center" of Ministry of Healthcare of Russian Federation

Moscow, Russia, 125167

Terminated/Withdrawn
4,659 miles (7,497 km)  awayfrom
New York City, New York
View on Map
Universitätsspital Basel

Universitätsspital CH, Petersgraben 4, 4031 Basel, Switzerland

Terminated/Withdrawn
3,880 miles (6,245 km)  awayfrom
New York City, New York
View on Map
Centre Hospitalier Universitaire Vaudois

Rue du Bugnon 46, 1011 Lausanne, Switzerland

Terminated/Withdrawn
3,871 miles (6,230 km)  awayfrom
New York City, New York
View on Map
Kantonsspital St. Gallen

Rorschacher Str. 95, 9001 St. Gallen, Switzerland

Terminated/Withdrawn
3,960 miles (6,373 km)  awayfrom
New York City, New York
View on Map
FMH Kinder und Jugendmedizin, im Wabern-Zentrum

Wabern bei Bern, 3084 Köniz, Switzerland

Terminated/Withdrawn
3,893 miles (6,266 km)  awayfrom
New York City, New York
View on Map
Kinderspital Zürich

Steinwiesstrasse 75, 8032 Zürich, Switzerland

Terminated/Withdrawn
3,927 miles (6,320 km)  awayfrom
New York City, New York
View on Map
Cambridge University Hospital NHS Foundation Trust, Addenbrooke's Hospital

Hills Rd, Cambridge CB2 0QQ, UK

Terminated/Withdrawn
3,454 miles (5,559 km)  awayfrom
New York City, New York
View on Map
UMHAP Sveti Georgï EAD

Plovdiv, Bulgaria

Terminated/Withdrawn
4,791 miles (7,710 km)  awayfrom
New York City, New York
View on Map
The Affiliated Hospital of Medical College, Qingdao University

16 Jiangsu Rd, Shinan Qu, Qingdao Shi, Shandong Sheng, China

Terminated/Withdrawn
7,051 miles (11,347 km)  awayfrom
New York City, New York
View on Map
CHRU Pellegrin

33076 Bordeaux, France

Terminated/Withdrawn
3,601 miles (5,795 km)  awayfrom
New York City, New York
View on Map
View all (105)
Trial Protocol ID: 061001
Back to Trial Summary