Trial at a glance
What medical condition is being studied? Hemophilia A
What is the trial testing? ADVATE Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (octocog alfa; rAHF-PFM); ADYNOVI Antihemophilic Factor (Recombinant) Pegylated (rurioctocog alfa pegol; rAHF-PEG)
How many participants are being enrolled? 1130
When is the trial being conducted? -
How long is participation in the trial? a. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) alone b. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) alone with a minimum follow up time of 4 years c. Up to approximately 12 years for currently enrolled subjects treated with rAHF-PFM and subsequently switched to rAHF-PEG (i.e. up to approx. 8 years on rAHF-PFM and at least 4 years on rAHF-PEG)
Key requirements
Sex
All
Age
All
Accepts Healthy Volunteers?
No
Trial Details / Participation Requirements
CLICK TO EXPANDCLICK TO COLLAPSE
Trial Type: Observational
Trial Arms/Groups or Cohorts:
rAHF-PFM: Participants treated with rAHF-PFM alone
rAHF-PEG: Participants treated with rAHF-PEG alone
rAHF-PFM then rAHF-PEG: Participants treated with rAHF-PFM and subsequently switched to rAHF-PEG
Intervention: ADVATE Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (octocog alfa; rAHF-PFM); ADYNOVI Antihemophilic Factor (Recombinant) Pegylated (rurioctocog alfa pegol; rAHF-PEG)
Primary Outcome Measure(s):
Joint Health Outcomes - Assessed by Physical Exam Using Only the Pain, Bleeding, and Physical Exam Parameters of the Gilbert Scale [Time Frame: Up to approximately 12 years]
Secondary Outcome Measure(s):
Annualized Bleed Rate, All Joints [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized Bleed Rate, All Bleeds [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized bleed rate, pre-existing target joints at baseline [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of New Target Joints [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health by X-ray by Pettersson scale [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit.]
Status of Joint Health by Magnetic Resonance Imaging (MRI) Scoring System- Using The Lund Scoring System (LSS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health using the Hemophilia Joint Health Score (HJHS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for prophylaxis therapy [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Compliance with the dosing prescribed and its relationship with effectiveness [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Global effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG units required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG infusions required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of target joint intervention, including surgery, radiosynovectomy, and chemosynovectomy [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of pseudo tumor development [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: HAL questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-12v2 questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D questionnaire - for adult patients [Time Frame: Enrollment visit;Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: PedHAL questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-10 questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D (14 and up) questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Chronic pain associated with hemophilia, as measured over a period of 4 weeks on an annual basis, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Acute pain associated with hemophilia, as measured with individual bleeding episodes, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Number of days lost from school or work due to bleeding episodes [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 1 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 2 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels Lesser than (<)1%, Lesser Than or Equal to (<=) 2%, and <= 5% without history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% with history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Untreated Patient (PUPs) and Minimally Treated Patients (MTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related non-serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of inhibitors after switching to rAHF-PEG [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Entry Criteria:
Inclusion Criteria:
• Participant has hemophilia A (FVIII ≤5%)
• Participant is prescribed Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) by the treating physician
• Participant or participant’s legally authorized representative provides informed consent
Exclusion Criteria:
• Participant has known hypersensitivity to the active substance or any of the excipients
• Participant has known allergic reaction to mouse or hamster proteins
• Participant has participated in another clinical study involving an investigational product (IP) or device within 30 days prior to study enrollment or is scheduled to participate in another clinical study involving another FVIII concentrate or device during the course of this study
Trial Locations
RESULTS
Kepler Universitätsklinikum Klinik für Kinder-und Jugendheilkunde
Krankenhausstraße 9, 4020 Linz, Austria
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Recruiting
5,657 miles (9,104 km) awayfrom
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Medizinische Universitaet Wien
Spitalgasse 23, 1090 Wien, Austria
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Recruiting
5,597 miles (9,008 km) awayfrom
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Hemoce - Ce
Av. José Bastos, 3390 - Rodolfo Teófilo, Fortaleza - CE, 60431-086, Brazil
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Recruiting
10,174 miles (16,373 km) awayfrom
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Hemocentro do Espírito Santo
Av. Mal. Campos, 1468 - Nazareth, Vitória - ES, 29047-105, Brazil
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Recruiting
11,323 miles (18,222 km) awayfrom
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Hemocentro da UNICAMP
Universidade Estadual de Campinas - R. Carlos Chagas, 480 - Cidade Universitária, Campinas - SP, 13083-878, Brazil
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Recruiting
11,440 miles (18,411 km) awayfrom
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Hemocentro Ribeirão Preto - SP
Rua Tenente Catão Roxo, 2501 Entrada pela - R. Prof. Hélio Lourenço - Vila Monte Alegre, Ribeirão Preto - SP, 14051-060, Brazil
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Recruiting
11,315 miles (18,210 km) awayfrom
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Hemepar - Pr
Tv. João Prosdócimo, 145 - Alto da XV, Curitiba - PR, 80045-145, Brazil
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Recruiting
11,548 miles (18,585 km) awayfrom
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Hemorgs - Rs
Av. Bento Gonçalves, 3722 - Partenon, Porto Alegre - RS, 90650-001, Brazil
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Recruiting
11,723 miles (18,866 km) awayfrom
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Hemorio - Rj
R. Frei Caneca, 8 - Centro, Rio de Janeiro - RJ, 20211-030, Brazil
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Recruiting
11,499 miles (18,506 km) awayfrom
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Faculdade de Medicina da Universidade de São Paulo
Pacaembu, São Paulo - State of São Paulo, 05403, Brazil
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Recruiting
11,496 miles (18,501 km) awayfrom
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Children's Hospital of Eastern Ontario
401 Smyth Rd, Ottawa, ON K1H 8L1, Canada
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Recruiting
6,396 miles (10,293 km) awayfrom
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Recruiting
6,415 miles (10,324 km) awayfrom
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Sick Kids Hospital
555 University Ave, Toronto, ON M5G 1X8, Canada
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Recruiting
6,414 miles (10,323 km) awayfrom
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Royal University Hospital
103 Hospital Dr, Saskatoon, SK S7N 0W8, Canada
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Recruiting
5,172 miles (8,323 km) awayfrom
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Nanfang Hospital Affiliated to Nanfang Medical University
1838 Guangzhou N Ave, Baiyun Qu, Guangzhou Shi, Guangdong Sheng, China
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Recruiting
1,760 miles (2,832 km) awayfrom
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The Affiliated Hospital of Xuzhou Medical University
Yunlong District, Xuzhou, China
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Recruiting
1,209 miles (1,946 km) awayfrom
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Recruiting
1,190 miles (1,915 km) awayfrom
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Shenzhen Second People's Hospital
3002 Sungang W Rd, Futian Qu, Shenzhen Shi, Guangdong Sheng, China
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Recruiting
1,748 miles (2,814 km) awayfrom
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Fundación Oftalmológica de Santander FOSCAL
Cl. 157 #23-99, Floridablanca, Santander, Colombia
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Recruiting
8,798 miles (14,160 km) awayfrom
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SBHI Chelyabinsk Regional Children's Clinical Hospital
Chelyabinsk, Chelyabinsk Oblast, Russia
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Recruiting
3,724 miles (5,994 km) awayfrom
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SBHI of the Republic of Kareliya Republican Hospital n.a. V.A. Baranov
Petrozavodsk, Republic of Karelia, Russia
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Recruiting
4,462 miles (7,181 km) awayfrom
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State Budget Healthcare Institution of Saint-Petersburg "City polyclinic #37"
St Petersburg, Russia, 191186
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Recruiting
4,645 miles (7,475 km) awayfrom
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Hospital Teresa Herrera-Materno Infantil
As, Xubias de Abaixo, s/n, 15009 A Coruña, Spain
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Recruiting
6,550 miles (10,542 km) awayfrom
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Hospital Universitari Vall d'Hebron (HUVH)
Passeig de la Vall d'Hebron, 119, 08035 Barcelona, Spain
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Recruiting
6,396 miles (10,294 km) awayfrom
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Hospital Hospital Sant Joan de Déu
Hospital Sant Joan de Déu, 08950, Barcelona, Spain
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Recruiting
6,400 miles (10,300 km) awayfrom
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Hospital Universitario Son Espases
Carretera de Valldemossa, 79, 07120 Palma, Illes Balears, Spain
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6,486 miles (10,438 km) awayfrom
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Sahlgrenska University Hospital
Blå stråket 5, 413 45 Göteborg, Sweden
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Recruiting
5,240 miles (8,433 km) awayfrom
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Kliniska studier i Sverige - Forum Söder
Skånes universitetssjukhus, Akutgatan 8, 221 85 Lund, Sweden
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5,310 miles (8,545 km) awayfrom
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Karolinska Universitetssjukhuset Solna
Karolinska Vägen 22, 171 64 Solna, Sweden
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Recruiting
5,005 miles (8,055 km) awayfrom
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Recruiting
5,934 miles (9,550 km) awayfrom
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Recruiting
5,903 miles (9,500 km) awayfrom
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Kantonsspital St. Gallen
Rorschacher Str. 95, 9001 St. Gallen, Switzerland
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Recruiting
5,851 miles (9,416 km) awayfrom
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Recruiting
5,878 miles (9,460 km) awayfrom
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Hampshire Hospitals NHS Foundation Trust, Basingstoke and North Hampshire Hospital
Aldermaston Rd, Basingstoke RG24 9NA, UK
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Recruiting
5,906 miles (9,505 km) awayfrom
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East Kent Hospitals University Foundation Trust, Kent & Canterbury Hospital
Ethelbert Rd, Canterbury CT1 3NG, UK
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5,856 miles (9,424 km) awayfrom
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Great Ormond Street Hospital for Children NHS Trust
Great Ormond Street, Holborn, London WC1N 3JH, UK
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Recruiting
5,869 miles (9,446 km) awayfrom
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Stollery Children's Hospital, University of Alberta
Edmonton, AB T6G 2B7, Canada
Currently On Hold
4,887 miles (7,865 km) awayfrom
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Royal Prince Alfred Hospital
50 Missenden Rd, Camperdown NSW 2050, Australia
4,923 miles (7,922 km) awayfrom
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Landes Frauen und Kinderklinik Linz (LFKK Linz)
Landes-Kinderklinik, Krankenhausstraße, 4020 Linz, Austria
5,657 miles (9,104 km) awayfrom
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Fundação HEMOPA
Tv. Padre Eutíquio, 2109 - Batista Campos, Belém - PA, 66033-000, Brazil
9,981 miles (16,063 km) awayfrom
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Fakultní nemocnice Brno
Jihlavská 340/20, 625 00 Brno-Bohunice-Brno-Starý Lískovec, Czechia
5,543 miles (8,920 km) awayfrom
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Fakultní nemocnice Ostrava, Krevní centrum
17. listopadu 833/9, 708 00 Ostrava-Poruba, Czechia
5,460 miles (8,787 km) awayfrom
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Fakultní nemocnice Ostrava, Oddělení dětské hematologie a hematoonkologie
17. listopadu 1790, 708 00 Ostrava-Poruba, Czechia
5,460 miles (8,787 km) awayfrom
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Fakultní nemocnice v Motole
V Úvalu 84, 150 06 Praha 5, Czechia
5,565 miles (8,957 km) awayfrom
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Rigshospitalet
Blegdamsvej 9, 2100 København, Denmark
5,327 miles (8,573 km) awayfrom
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CHU Côte de Nacre - CRTH
Avenue de la Côte de Nacre, 14000 Caen, France
6,010 miles (9,673 km) awayfrom
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Hôpital André Mignot
177 Rue de Versailles, 78150 Le Chesnay, France
5,971 miles (9,609 km) awayfrom
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Hôpital de la Mère et de l'Enfant - CHU de LIMOGES
8 Avenue Dominique Larrey, 87000 Limoges, France
6,168 miles (9,926 km) awayfrom
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CHU de Reims Hôpital Maison Blanche - CRTH
45 Rue Cognacq-Jay, 51092 Reims, France
5,900 miles (9,495 km) awayfrom
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CIC
2 Allée des Artilleurs, 42000 Saint-Étienne, France
6,103 miles (9,821 km) awayfrom
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Aghia Sofia Children's Hospital
Thivon 1, Athina 115 27, Greece
5,827 miles (9,377 km) awayfrom
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Laikon General Hospital
Goudi, Athens 115 27, Greece
5,827 miles (9,377 km) awayfrom
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General Hospital of Thessaloniki "Ippokratio"
Konstantinoupoleos 49, Thessaloniki 546 42, Greece
5,735 miles (9,229 km) awayfrom
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Heim Pál Gyermekkórház
Budapest, Üllői út 86, 1089 Hungary
5,545 miles (8,923 km) awayfrom
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Debreceni Egyetem Klinikai Kozpont
Debrecen, Nagyerdei krt. 98, 4032 Hungary
5,456 miles (8,780 km) awayfrom
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Mohács City Hospital
Mohács, Szepessy tér 7, 7700 Hungary
5,631 miles (9,062 km) awayfrom
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Azienda Ospedaliera Policlinico Consorziale Di Bari
Piazza Giulio Cesare, 11, 70124 Bari BA, Italy
5,936 miles (9,554 km) awayfrom
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Policlinico S Orsola Malpighi
Via Giuseppe Massarenti, 9, 40138 Bologna BO, Italy
5,948 miles (9,572 km) awayfrom
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Azienda Ospedaliera Universitaria Vittorio Emanuele, Ferrarotto, S. Bambino
Via Salvatore Citelli, 1, 95124 Catania CT, Italy
6,184 miles (9,953 km) awayfrom
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Ospedale Pugliese -Ciaccio
Viale Papa Pio X, 83, 88100 Catanzaro CZ, Italy
6,057 miles (9,748 km) awayfrom
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Az. Osp. Univ. Careggi
Largo Piero Palagi, 1, 50139 Firenze FI, Italy
5,987 miles (9,636 km) awayfrom
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Ospedale di Macerata
Via Santa Lucia, 2, 62100 Macerata MC, Italy
5,942 miles (9,563 km) awayfrom
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Via della Commenda, 10, 20122 Milano MI, Italy
5,963 miles (9,596 km) awayfrom
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Azienda Ospedaliera Universitaria Federico II
Via Sergio Pansini, 5, 80131 Napoli NA, Italy
6,042 miles (9,724 km) awayfrom
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Azienda Ospedaliera di Padova Clinica Medica II
Via Gustavo Modena, 9, 35128 Padova PD, Italy
5,883 miles (9,468 km) awayfrom
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AOUP P. Giaccone
Via del Vespro, 129, 90127 Palermo PA, Italy
6,216 miles (10,003 km) awayfrom
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Azienda Ospedaliera Bianchi Melacrino Morelli
Via Giuseppe Melacrino, 21, 89124 Reggio Calabria RC, Italy
6,132 miles (9,868 km) awayfrom
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Università degli studi di Roma "La Sapienza"
Viale Regina Elena, 334, 00161 Roma RM, Italy
6,046 miles (9,730 km) awayfrom
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Ospedale Pediatrico Bambino Gesù
Piazza di Sant'Onofrio, 4, 00165 Roma RM, Italy
6,049 miles (9,734 km) awayfrom
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Centro Emofilia e Coagulopatie Rare
73020 Scorrano, Province of Lecce, Italy
5,938 miles (9,556 km) awayfrom
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Ospedale Molinette
Via Cherasco, 15, 10126 Torino TO, Italy
6,031 miles (9,707 km) awayfrom
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Rikshospitalet
Sognsvannsveien 20, 0372 Oslo, Norway
5,152 miles (8,292 km) awayfrom
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Rikshospitalet, Oslo University Hospital
Sognsvannsveien 20, 0372 Oslo, Norway
5,152 miles (8,292 km) awayfrom
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Hospital do Divino Espírito Santo
Av. D. Manuel I, 9500-370 Ponta Delgada, Portugal
7,216 miles (11,613 km) awayfrom
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Centro Hospitalar e Universitade de Coimbra
Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal
6,744 miles (10,854 km) awayfrom
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Federal State Budget Institution "Hematology Research Center" of Ministry of Healthcare of Russian Federation
Moscow, Russia, 125167
4,572 miles (7,358 km) awayfrom
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University Medical Centre Ljubljana
Zaloška cesta 7, 1000 Ljubljana, Slovenia
5,765 miles (9,278 km) awayfrom
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South Metropolitan Health Service trading as Fiona Stanley Hospital
14 Barry Marshall Parade, Murdoch WA 6150, Australia
4,953 miles (7,971 km) awayfrom
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æâ¥æŬ
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Cliniques Universitaires Saint-Luc
Avenue Hippocrate 10, 1200 Bruxelles, Belgium
5,797 miles (9,330 km) awayfrom
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The Moncton City Hospital
135 Macbeath Ave, Moncton, NB E1C 6Z8, Canada
6,554 miles (10,548 km) awayfrom
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"Hôpital Morvan CHRU de Brest"
2 Avenue Foch, 29200 Brest, France
6,154 miles (9,904 km) awayfrom
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Centre Hospitalier Générale - CTH
Maternité, Rue Lucien Biset, 73000 Chambéry, France
6,054 miles (9,743 km) awayfrom
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CTRH - CHU Bocage
21000 Dijon, France
5,980 miles (9,624 km) awayfrom
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CHRU Hôtel Dieu - CRTH
1 Place Alexis-Ricordeau, 44093 Nantes, France
6,157 miles (9,908 km) awayfrom
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Hôpital Cochin
27 Rue du Faubourg Saint-Jacques, 75014 Paris, France
5,965 miles (9,600 km) awayfrom
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Centre Régional de Traitement de l'Hémophilie et des Maladies hémorragiques. CHU de Rennes - Hôpital Pontchaillou
2 Rue Henri le Guilloux, 35000 Rennes, France
6,106 miles (9,827 km) awayfrom
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CHRU Charles Nicolle
37 Boulevard Gambetta, 76000 Rouen, France
5,961 miles (9,594 km) awayfrom
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CHRU Purpan CRTH - Pavillon Sénac
9, 9 Place Lange, 31300 Toulouse, France
6,291 miles (10,124 km) awayfrom
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Jósa András County Hospital
Nyíregyháza, Jósa András u., 4400 Hungary
5,434 miles (8,746 km) awayfrom
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Markusovszky Hospital
Szombathely, Markusovszky Lajos u. 5, 9700 Hungary
5,638 miles (9,073 km) awayfrom
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Policlinico Universitario Gemelli
Via della Pineta Sacchetti, 217, 00168 Roma RM, Italy
6,048 miles (9,733 km) awayfrom
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Szpital Uniwersytecki nr 1 im. dr Andrzeja Jurasza
Marii Skłodowskiej Curie 9, 85-094 Bydgoszcz, Poland
5,304 miles (8,535 km) awayfrom
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Samodzielny Publiczny Szpital Kliniczny nr 1
Gdańsk, Poland
5,227 miles (8,411 km) awayfrom
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Samodzielny Publiczny Dzieciecy Szpital Kliniczny
Żwirki i Wigury 63A, 02-091 Warszawa, Poland
5,258 miles (8,462 km) awayfrom
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Uniwersytecki Szpital Kliniczny we Wrocławiu
Borowska 213, 50-556 Wrocław, Poland
5,434 miles (8,745 km) awayfrom
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Centro Hospitalar Lisboa Norte Hospital de Sta. Maria
Av. Prof. Egas Moniz MB, 1649-028 Lisboa, Portugal
6,853 miles (11,029 km) awayfrom
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Centro Hospitalar de São João, E.P.E.
Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
6,689 miles (10,765 km) awayfrom
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Universitätsspital Basel
Universitätsspital CH, Petersgraben 4, 4031 Basel, Switzerland
5,896 miles (9,488 km) awayfrom
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Centre Hospitalier Universitaire Vaudois
Rue du Bugnon 46, 1011 Lausanne, Switzerland
5,980 miles (9,623 km) awayfrom
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FMH Kinder und Jugendmedizin, im Wabern-Zentrum
Wabern bei Bern, 3084 Köniz, Switzerland
5,934 miles (9,550 km) awayfrom
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Kinderspital Zürich
Steinwiesstrasse 75, 8032 Zürich, Switzerland
5,878 miles (9,460 km) awayfrom
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æâ¥æŬ
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Cambridge University Hospital NHS Foundation Trust, Addenbrooke's Hospital
Hills Rd, Cambridge CB2 0QQ, UK
5,825 miles (9,375 km) awayfrom
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æâ¥æŬ
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UMHAP Sveti Georgï EAD
Plovdiv, Bulgaria
5,596 miles (9,005 km) awayfrom
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æâ¥æŬ
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The Affiliated Hospital of Medical College, Qingdao University
16 Jiangsu Rd, Shinan Qu, Qingdao Shi, Shandong Sheng, China
1,017 miles (1,636 km) awayfrom
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æâ¥æŬ
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CHRU Pellegrin
33076 Bordeaux, France
6,273 miles (10,096 km) awayfrom
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View all (105)
Trial Protocol ID: 061001
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