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ADVATE/ ADYNOVI Hemophilia A Outcome Database (AHEAD)

IDENTIFIERS
Trial Protocol: 061001
Clinicaltrials.gov: NCT02078427
PURPOSE

The purpose of the study is to document the natural history of hemophilia A disease and long-term outcomes in terms of effectiveness, safety and quality of life in participants receiving Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) in routine clinical practice

Recruiting
AU
AT
BE
20+
BR
BG
CA
CN
CO
CZ
DK
FR
GR
HU
IT
NO
PL
PT
RU
SI
ES
SE
CH
GB

Trial at a glance

What medical condition is being studied?   Hemophilia A
What is the trial testing?   ADVATE Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (octocog alfa; rAHF-PFM); ADYNOVI Antihemophilic Factor (Recombinant) Pegylated (rurioctocog alfa pegol; rAHF-PEG)
How many participants are being enrolled?   1130
When is the trial being conducted?    - 
How long is participation in the trial?   a. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) alone b. Up to 8 years of treatment if treated with Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) alone with a minimum follow up time of 4 years c. Up to approximately 12 years for currently enrolled subjects treated with rAHF-PFM and subsequently switched to rAHF-PEG (i.e. up to approx. 8 years on rAHF-PFM and at least 4 years on rAHF-PEG)

Key requirements

Sex   
All
Age   
All
Accepts Healthy Volunteers?   
No

Trial Details / Participation Requirements

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Trial Type:   Observational
Trial Arms/Groups or Cohorts:   
rAHF-PFM: Participants treated with rAHF-PFM alone
rAHF-PEG: Participants treated with rAHF-PEG alone
rAHF-PFM then rAHF-PEG: Participants treated with rAHF-PFM and subsequently switched to rAHF-PEG
Intervention:   ADVATE Antihemophilic Factor (Recombinant), Plasma/Albumin-Free Method (octocog alfa; rAHF-PFM); ADYNOVI Antihemophilic Factor (Recombinant) Pegylated (rurioctocog alfa pegol; rAHF-PEG)
Primary Outcome Measure(s):
Joint Health Outcomes - Assessed by Physical Exam Using Only the Pain, Bleeding, and Physical Exam Parameters of the Gilbert Scale [Time Frame: Up to approximately 12 years]
Secondary Outcome Measure(s):   
Annualized Bleed Rate, All Joints [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized Bleed Rate, All Bleeds [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Annualized bleed rate, pre-existing target joints at baseline [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of New Target Joints [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health by X-ray by Pettersson scale [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit.]
Status of Joint Health by Magnetic Resonance Imaging (MRI) Scoring System- Using The Lund Scoring System (LSS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Status of joint health using the Hemophilia Joint Health Score (HJHS) [Time Frame: Screening visit; Annual/Interval visits:- Up to 8 years if rAHF-PFM alone- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for prophylaxis therapy [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Compliance with the dosing prescribed and its relationship with effectiveness [Time Frame: Annual/Interval visits:- Up to 8 years if rAHF-PFM alone;- Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years;- Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Overall effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Global effectiveness assessment for on-demand treatment [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG units required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Number of rAHF-PFM or rAHF-PEG infusions required for bleed cessation [Time Frame: Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of target joint intervention, including surgery, radiosynovectomy, and chemosynovectomy [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; and Termination visit]
Incidence of pseudo tumor development [Time Frame: Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: HAL questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-12v2 questionnaire - for adult patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D questionnaire - for adult patients [Time Frame: Enrollment visit;Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: PedHAL questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: SF-10 questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Quality of Life: EQ-5D (14 and up) questionnaire - for pediatric patients [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Chronic pain associated with hemophilia, as measured over a period of 4 weeks on an annual basis, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Acute pain associated with hemophilia, as measured with individual bleeding episodes, using the visual analog scale (VAS) [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Number of days lost from school or work due to bleeding episodes [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 1 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Modalities of switching from a standard FVIII product to rAHF-PEG - 2 [Time Frame: Enrollment visit; Screening visit; Annual/Interval visits: - Up to 8 years if rAHF-PFM alone - Up to 8 years if rAHF-PEG alone with minimum follow up of 4 years - Up to approx. 12 years rAHF-PFM and switched to rAHF-PEG; Termination visit]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels Lesser than (<)1%, Lesser Than or Equal to (<=) 2%, and <= 5% without history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Treated Patients (PTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% with history of inhibitor [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of Inhibitors in Previously Untreated Patient (PUPs) and Minimally Treated Patients (MTPs) with Factor VIII (FVIII) Levels <1%, <=2%, and <= 5% [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of therapy-related non-serious adverse events [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Incidence of inhibitors after switching to rAHF-PEG [Time Frame: Throughout the study period of up to approximately: 8 years (rAHF-PFM alone), or 12 years (rAHF-PEG alone or after receiving rAHF-PFM)]
Entry Criteria:
Inclusion Criteria: • Participant has hemophilia A (FVIII ≤5%) • Participant is prescribed Antihemophilic Factor (Recombinant) – Plasma/Albumin Free Method (rAHF-PFM) or Antihemophilic Factor (Recombinant) – Pegylated (rAHF-PEG) by the treating physician • Participant or participant’s legally authorized representative provides informed consent Exclusion Criteria: • Participant has known hypersensitivity to the active substance or any of the excipients • Participant has known allergic reaction to mouse or hamster proteins • Participant has participated in another clinical study involving an investigational product (IP) or device within 30 days prior to study enrollment or is scheduled to participate in another clinical study involving another FVIII concentrate or device during the course of this study

Trial Locations

Any
Completed
Terminated
Recruiting
Withdrawn
Suspended
Any
RESULTS
Kepler Universitätsklinikum Klinik für Kinder-und Jugendheilkunde

Krankenhausstraße 9, 4020 Linz, Austria

Recruiting
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Medizinische Universitaet Wien

Spitalgasse 23, 1090 Wien, Austria

Recruiting
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Hemoce - Ce

Av. José Bastos, 3390 - Rodolfo Teófilo, Fortaleza - CE, 60431-086, Brazil

Recruiting
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Hemocentro do Espírito Santo

Av. Mal. Campos, 1468 - Nazareth, Vitória - ES, 29047-105, Brazil

Site Contact
Recruiting
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Hemocentro da UNICAMP

Universidade Estadual de Campinas - R. Carlos Chagas, 480 - Cidade Universitária, Campinas - SP, 13083-878, Brazil

Recruiting
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Hemocentro Ribeirão Preto - SP

Rua Tenente Catão Roxo, 2501 Entrada pela - R. Prof. Hélio Lourenço - Vila Monte Alegre, Ribeirão Preto - SP, 14051-060, Brazil

Recruiting
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Hemepar - Pr

Tv. João Prosdócimo, 145 - Alto da XV, Curitiba - PR, 80045-145, Brazil

Recruiting
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Hemorgs - Rs

Av. Bento Gonçalves, 3722 - Partenon, Porto Alegre - RS, 90650-001, Brazil

Recruiting
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Hemorio - Rj

R. Frei Caneca, 8 - Centro, Rio de Janeiro - RJ, 20211-030, Brazil

Recruiting
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Faculdade de Medicina da Universidade de São Paulo

Pacaembu, São Paulo - State of São Paulo, 05403, Brazil

Recruiting
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Children's Hospital of Eastern Ontario

401 Smyth Rd, Ottawa, ON K1H 8L1, Canada

Recruiting
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St-Michael's Hospital

30 Bond St, Toronto, ON M5B 1W8, Canada

Site Contact
Recruiting
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Sick Kids Hospital

555 University Ave, Toronto, ON M5G 1X8, Canada

Recruiting
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Royal University Hospital

103 Hospital Dr, Saskatoon, SK S7N 0W8, Canada

Recruiting
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Nanfang Hospital Affiliated to Nanfang Medical University

1838 Guangzhou N Ave, Baiyun Qu, Guangzhou Shi, Guangdong Sheng, China

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Recruiting
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The Affiliated Hospital of Xuzhou Medical University

Yunlong District, Xuzhou, China

Site Contact
Recruiting
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The Blood Center of Shandong Province

Jinan, Shandong, China

Recruiting
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Shenzhen Second People's Hospital

3002 Sungang W Rd, Futian Qu, Shenzhen Shi, Guangdong Sheng, China

Recruiting
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Fundación Oftalmológica de Santander FOSCAL

Cl. 157 #23-99, Floridablanca, Santander, Colombia

Recruiting
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SBHI Chelyabinsk Regional Children's Clinical Hospital

Chelyabinsk, Chelyabinsk Oblast, Russia

Site Contact
Recruiting
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SBHI of the Republic of Kareliya Republican Hospital n.a. V.A. Baranov

Petrozavodsk, Republic of Karelia, Russia

Recruiting
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State Budget Healthcare Institution of Saint-Petersburg "City polyclinic #37"

St Petersburg, Russia, 191186

Recruiting
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Hospital Teresa Herrera-Materno Infantil

As, Xubias de Abaixo, s/n, 15009 A Coruña, Spain

Recruiting
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Hospital Universitari Vall d'Hebron (HUVH)

Passeig de la Vall d'Hebron, 119, 08035 Barcelona, Spain

Recruiting
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Hospital Hospital Sant Joan de Déu

Hospital Sant Joan de Déu, 08950, Barcelona, Spain

Recruiting
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Hospital Universitario Son Espases

Carretera de Valldemossa, 79, 07120 Palma, Illes Balears, Spain

Recruiting
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Sahlgrenska University Hospital

Blå stråket 5, 413 45 Göteborg, Sweden

Recruiting
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Kliniska studier i Sverige - Forum Söder

Skånes universitetssjukhus, Akutgatan 8, 221 85 Lund, Sweden

Recruiting
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Karolinska Universitetssjukhuset Solna

Karolinska Vägen 22, 171 64 Solna, Sweden

Recruiting
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Inselspital Bern

Freiburgstrasse 18, 3010 Bern, Switzerland

Recruiting
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Luzerner Kantonsspital

Spitalstrasse, 6004 Luzern, Switzerland

Recruiting
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Kantonsspital St. Gallen

Rorschacher Str. 95, 9001 St. Gallen, Switzerland

Recruiting
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Universitätsspital Zürich

Rämistrasse 100, 8091 Zürich, Switzerland

Recruiting
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Hampshire Hospitals NHS Foundation Trust, Basingstoke and North Hampshire Hospital

Aldermaston Rd, Basingstoke RG24 9NA, UK

Recruiting
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East Kent Hospitals University Foundation Trust, Kent & Canterbury Hospital

Ethelbert Rd, Canterbury CT1 3NG, UK

Recruiting
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Great Ormond Street Hospital for Children NHS Trust

Great Ormond Street, Holborn, London WC1N 3JH, UK

Recruiting
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Stollery Children's Hospital, University of Alberta

Edmonton, AB T6G 2B7, Canada

Currently On Hold
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Royal Prince Alfred Hospital

50 Missenden Rd, Camperdown NSW 2050, Australia

Completed
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Landes Frauen und Kinderklinik Linz (LFKK Linz)

Landes-Kinderklinik, Krankenhausstraße, 4020 Linz, Austria

Completed
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Fundação HEMOPA

Tv. Padre Eutíquio, 2109 - Batista Campos, Belém - PA, 66033-000, Brazil

Completed
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Fakultní nemocnice Brno

Jihlavská 340/20, 625 00 Brno-Bohunice-Brno-Starý Lískovec, Czechia

Completed
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Fakultní nemocnice Ostrava, Krevní centrum

17. listopadu 833/9, 708 00 Ostrava-Poruba, Czechia

Completed
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Fakultní nemocnice Ostrava, Oddělení dětské hematologie a hematoonkologie

17. listopadu 1790, 708 00 Ostrava-Poruba, Czechia

Completed
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Fakultní nemocnice v Motole

V Úvalu 84, 150 06 Praha 5, Czechia

Completed
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Rigshospitalet

Blegdamsvej 9, 2100 København, Denmark

Completed
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CHU Côte de Nacre - CRTH

Avenue de la Côte de Nacre, 14000 Caen, France

Completed
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Hôpital André Mignot

177 Rue de Versailles, 78150 Le Chesnay, France

Completed
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Hôpital de la Mère et de l'Enfant - CHU de LIMOGES

8 Avenue Dominique Larrey, 87000 Limoges, France

Completed
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CHU de Reims Hôpital Maison Blanche - CRTH

45 Rue Cognacq-Jay, 51092 Reims, France

Completed
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CIC

2 Allée des Artilleurs, 42000 Saint-Étienne, France

Completed
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Aghia Sofia Children's Hospital

Thivon 1, Athina 115 27, Greece

Completed
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Laikon General Hospital

Goudi, Athens 115 27, Greece

Completed
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General Hospital of Thessaloniki "Ippokratio"

Konstantinoupoleos 49, Thessaloniki 546 42, Greece

Completed
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Heim Pál Gyermekkórház

Budapest, Üllői út 86, 1089 Hungary

Completed
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Debreceni Egyetem Klinikai Kozpont

Debrecen, Nagyerdei krt. 98, 4032 Hungary

Completed
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Mohács City Hospital

Mohács, Szepessy tér 7, 7700 Hungary

Completed
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Azienda Ospedaliera Policlinico Consorziale Di Bari

Piazza Giulio Cesare, 11, 70124 Bari BA, Italy

Completed
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Policlinico S Orsola Malpighi

Via Giuseppe Massarenti, 9, 40138 Bologna BO, Italy

Completed
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Azienda Ospedaliera Universitaria Vittorio Emanuele, Ferrarotto, S. Bambino

Via Salvatore Citelli, 1, 95124 Catania CT, Italy

Completed
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Ospedale Pugliese -Ciaccio

Viale Papa Pio X, 83, 88100 Catanzaro CZ, Italy

Completed
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Az. Osp. Univ. Careggi

Largo Piero Palagi, 1, 50139 Firenze FI, Italy

Completed
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Ospedale di Macerata

Via Santa Lucia, 2, 62100 Macerata MC, Italy

Completed
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Via della Commenda, 10, 20122 Milano MI, Italy

Completed
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Azienda Ospedaliera Universitaria Federico II

Via Sergio Pansini, 5, 80131 Napoli NA, Italy

Completed
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Azienda Ospedaliera di Padova Clinica Medica II

Via Gustavo Modena, 9, 35128 Padova PD, Italy

Completed
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AOUP P. Giaccone

Via del Vespro, 129, 90127 Palermo PA, Italy

Completed
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Azienda Ospedaliera Bianchi Melacrino Morelli

Via Giuseppe Melacrino, 21, 89124 Reggio Calabria RC, Italy

Completed
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Università degli studi di Roma "La Sapienza"

Viale Regina Elena, 334, 00161 Roma RM, Italy

Completed
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Ospedale Pediatrico Bambino Gesù

Piazza di Sant'Onofrio, 4, 00165 Roma RM, Italy

Completed
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Centro Emofilia e Coagulopatie Rare

73020 Scorrano, Province of Lecce, Italy

Completed
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Ospedale Molinette

Via Cherasco, 15, 10126 Torino TO, Italy

Completed
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Rikshospitalet

Sognsvannsveien 20, 0372 Oslo, Norway

Completed
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Rikshospitalet, Oslo University Hospital

Sognsvannsveien 20, 0372 Oslo, Norway

Completed
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Hospital do Divino Espírito Santo

Av. D. Manuel I, 9500-370 Ponta Delgada, Portugal

Completed
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Centro Hospitalar e Universitade de Coimbra

Praceta Professor Mota Pinto, 3004-561 Coimbra, Portugal

Completed
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Federal State Budget Institution "Hematology Research Center" of Ministry of Healthcare of Russian Federation

Moscow, Russia, 125167

Completed
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University Medical Centre Ljubljana

Zaloška cesta 7, 1000 Ljubljana, Slovenia

Completed
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South Metropolitan Health Service trading as Fiona Stanley Hospital

14 Barry Marshall Parade, Murdoch WA 6150, Australia

Terminated/Withdrawn
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Cliniques Universitaires Saint-Luc

Avenue Hippocrate 10, 1200 Bruxelles, Belgium

Terminated/Withdrawn
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The Moncton City Hospital

135 Macbeath Ave, Moncton, NB E1C 6Z8, Canada

Terminated/Withdrawn
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"Hôpital Morvan CHRU de Brest"

2 Avenue Foch, 29200 Brest, France

Terminated/Withdrawn
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Centre Hospitalier Générale - CTH

Maternité, Rue Lucien Biset, 73000 Chambéry, France

Terminated/Withdrawn
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CTRH - CHU Bocage

21000 Dijon, France

Terminated/Withdrawn
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CHRU Hôtel Dieu - CRTH

1 Place Alexis-Ricordeau, 44093 Nantes, France

Terminated/Withdrawn
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Hôpital Cochin

27 Rue du Faubourg Saint-Jacques, 75014 Paris, France

Terminated/Withdrawn
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Centre Régional de Traitement de l'Hémophilie et des Maladies hémorragiques. CHU de Rennes - Hôpital Pontchaillou

2 Rue Henri le Guilloux, 35000 Rennes, France

Terminated/Withdrawn
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CHRU Charles Nicolle

37 Boulevard Gambetta, 76000 Rouen, France

Terminated/Withdrawn
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CHRU Purpan CRTH - Pavillon Sénac

9, 9 Place Lange, 31300 Toulouse, France

Terminated/Withdrawn
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Jósa András County Hospital

Nyíregyháza, Jósa András u., 4400 Hungary

Terminated/Withdrawn
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Markusovszky Hospital

Szombathely, Markusovszky Lajos u. 5, 9700 Hungary

Terminated/Withdrawn
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Policlinico Universitario Gemelli

Via della Pineta Sacchetti, 217, 00168 Roma RM, Italy

Terminated/Withdrawn
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Szpital Uniwersytecki nr 1 im. dr Andrzeja Jurasza

Marii Skłodowskiej Curie 9, 85-094 Bydgoszcz, Poland

Terminated/Withdrawn
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Samodzielny Publiczny Szpital Kliniczny nr 1

Gdańsk, Poland

Terminated/Withdrawn
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Samodzielny Publiczny Dzieciecy Szpital Kliniczny

Żwirki i Wigury 63A, 02-091 Warszawa, Poland

Terminated/Withdrawn
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Uniwersytecki Szpital Kliniczny we Wrocławiu

Borowska 213, 50-556 Wrocław, Poland

Terminated/Withdrawn
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Centro Hospitalar Lisboa Norte Hospital de Sta. Maria

Av. Prof. Egas Moniz MB, 1649-028 Lisboa, Portugal

Terminated/Withdrawn
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Centro Hospitalar de São João, E.P.E.

Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal

Terminated/Withdrawn
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Universitätsspital Basel

Universitätsspital CH, Petersgraben 4, 4031 Basel, Switzerland

Terminated/Withdrawn
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Centre Hospitalier Universitaire Vaudois

Rue du Bugnon 46, 1011 Lausanne, Switzerland

Terminated/Withdrawn
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FMH Kinder und Jugendmedizin, im Wabern-Zentrum

Wabern bei Bern, 3084 Köniz, Switzerland

Terminated/Withdrawn
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Kinderspital Zürich

Steinwiesstrasse 75, 8032 Zürich, Switzerland

Terminated/Withdrawn
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Cambridge University Hospital NHS Foundation Trust, Addenbrooke's Hospital

Hills Rd, Cambridge CB2 0QQ, UK

Terminated/Withdrawn
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UMHAP Sveti Georgï EAD

Plovdiv, Bulgaria

Terminated/Withdrawn
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The Affiliated Hospital of Medical College, Qingdao University

16 Jiangsu Rd, Shinan Qu, Qingdao Shi, Shandong Sheng, China

Terminated/Withdrawn
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CHRU Pellegrin

33076 Bordeaux, France

Terminated/Withdrawn
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View all (105)
Trial Protocol ID: 061001
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